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Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

Miscellaneous

The intein interrupts the ATP-binding site.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-5-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Cleaved into the following chain:
Alternative name(s):
Tac VMA intein
Gene namesi
Name:atpA
Ordered Locus Names:Ta0004
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000024701 – 235V-type ATP synthase alpha chain, 1st partSequence analysisAdd BLAST235
ChainiPRO_0000002471236 – 409Tac AtpA inteinSequence analysisAdd BLAST174
ChainiPRO_0000002472410 – 764V-type ATP synthase alpha chain, 2nd partSequence analysisAdd BLAST355

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PRIDEiQ9P997

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0004

Structurei

3D structure databases

ProteinModelPortaliQ9P997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiarCOG00868 Archaea
COG1155 LUCA
COG1372 LUCA
HOGENOMiHOG000161057
KOiK02117
OMAiHNTVTQH
OrthoDBiPOG093Z00V1

Family and domain databases

Gene3Di1.10.1140.10, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_00309 ATP_synth_A_arch, 1 hit
InterProiView protein in InterPro
IPR031686 ATP-synth_a_Xtn
IPR023366 ATP_synth_asu-like_sf
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034 ATPase_F1/V1_b/a_C
IPR003586 Hint_dom_C
IPR003587 Hint_dom_N
IPR036844 Hint_dom_sf
IPR030934 Intein_C
IPR006141 Intein_N
IPR027417 P-loop_NTPase
IPR022878 V-ATPase_asu
PANTHERiPTHR43607 PTHR43607, 2 hits
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 2 hits
PF02874 ATP-synt_ab_N, 1 hit
PF16886 ATP-synt_ab_Xtn, 1 hit
SMARTiView protein in SMART
SM00305 HintC, 1 hit
SM00306 HintN, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF51294 SSF51294, 1 hit
SSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR01443 intein_Cterm, 1 hit
TIGR01445 intein_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit
PS50818 INTEIN_C_TER, 1 hit
PS50817 INTEIN_N_TER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIIRISGP VVVAEDVEDA KMYDVVKVGE MGLIGEIIKI EGNRSTIQVY
60 70 80 90 100
EDTAGIRPDE KVENTRRPLS VELGPGILKS IYDGIQRPLD VIKITSGDFI
110 120 130 140 150
ARGLNPPALD RQKKWEFVPA VKKGETVFPG QILGTVQETS LITHRIMVPE
160 170 180 190 200
GISGKVTMIA DGEHRVEDVI ATVSGNGKSY DIQMMTTWPV RKARRVQRKL
210 220 230 240 250
PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGD TPVLLDAGER
260 270 280 290 300
RIGDLFMEAI QDQKNAVEIG QNEEIVRLHD PLRIYSMVGS EIVESVSHAI
310 320 330 340 350
YHGKSNAIVT VRTENGREVR VTPVHKLFVK IGNSVIERPA SEVNEGDEIA
360 370 380 390 400
CASVSENGDS QTVTTTLVLT FDRVVSKEMH SGVFDVYDLM VPDYGYNFIG
410 420 430 440 450
GNGLIVLHNT VIQHQLAKWS DANIVVYIGC GERGNEMTEI LTTFPELKDP
460 470 480 490 500
NTGQPLMDRT VLIANTSNMP VAAREASIYT GITIAEYYRD MGYDVALMAD
510 520 530 540 550
STSRWAEALR EISGRLEEMP GEEGYPAYLG RRVSEFYERS GRARLVSPDE
560 570 580 590 600
RYGSITVIGA VSPPGGDISE PVSQNTLRVT RVFWALDAAL ANRRHFPSIN
610 620 630 640 650
WLNSYSLYTE DLRSWYDKNV SSEWSALRER AMEILQRESE LQEVAQLVGY
660 670 680 690 700
DAMPEKEKSI LDVARIIRED FLQQSAFDEI DAYCSLKKQY LMLKAIMEID
710 720 730 740 750
TYQNKALDSG ATMDNLASLA VREKLSRMKI VPEAQVESYY NDLVEEIHKE
760
YGNFIGEKNA EASL
Length:764
Mass (Da):84,825
Last modified:January 24, 2001 - v2
Checksum:iF1CF0EF37770306E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201 – 204PPEI → LSRD in CAB99208 (PubMed:11722801).Curated4
Sequence conflicti201 – 204PPEI → LSRD in AAF88065 (PubMed:11722801).Curated4
Sequence conflicti209 – 216GQRVIDAL → AQSGNRCA in CAB99208 (PubMed:11722801).Curated8
Sequence conflicti221 – 226KGGTAA → EAANCR in CAB99208 (PubMed:11722801).Curated6
Sequence conflicti221 – 226KGGTAA → EAANCR in AAF88065 (PubMed:11722801).Curated6
Sequence conflicti261 – 267QDQKNAV → RPKERG in CAB99208 (PubMed:11722801).Curated7
Sequence conflicti261 – 267QDQKNAV → RPKERG in AAF88065 (PubMed:11722801).Curated7
Sequence conflicti281 – 282PL → SW in CAB99208 (PubMed:11722801).Curated2
Sequence conflicti281 – 282PL → SW in AAF88065 (PubMed:11722801).Curated2
Sequence conflicti295S → T in CAB99208 (PubMed:11722801).Curated1
Sequence conflicti295S → T in AAF88065 (PubMed:11722801).Curated1
Sequence conflicti295S → T in BAB00608 (PubMed:11722801).Curated1
Sequence conflicti310T → N in CAB99208 (PubMed:11722801).Curated1
Sequence conflicti310T → N in AAF88065 (PubMed:11722801).Curated1
Sequence conflicti310T → N in BAB00608 (PubMed:11722801).Curated1
Sequence conflicti351 – 352CA → WP in CAB99208 (PubMed:11722801).Curated2
Sequence conflicti351 – 352CA → WP in AAF88065 (PubMed:11722801).Curated2
Sequence conflicti458 – 462DRTVL → TGLSF in CAB99208 (PubMed:11722801).Curated5
Sequence conflicti458 – 462DRTVL → TGLSF in AAF88065 (PubMed:11722801).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292523 mRNA Translation: CAB99208.1
AF286477 mRNA Translation: AAF88065.1
AB045977 mRNA Translation: BAB00608.1
AL445063 Genomic DNA Translation: CAC11153.1
RefSeqiWP_010900431.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC11153; CAC11153; CAC11153
GeneIDi1455676
KEGGitac:Ta0004

Similar proteinsi

Entry informationi

Entry nameiVATA_THEAC
AccessioniPrimary (citable) accession number: Q9P997
Secondary accession number(s): Q9HM65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health