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Q9P997 (VATA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type ATP synthase alpha chain
EC=3.6.3.14
Alternative name(s):
V-ATPase subunit A

Cleaved into the following chain:

  1. Tac AtpA intein
    Alternative name(s):
    Tac VMA intein
Gene names
Name:atpA
Ordered Locus Names:Ta0004
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma ›

Protein attributes

Sequence length764 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP-Rule MF_00309

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP-Rule MF_00309

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation Potential. HAMAP-Rule MF_00309

Miscellaneous

The intein interrupts the ATP-binding site. HAMAP-Rule MF_00309

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235V-type ATP synthase alpha chain, 1st part Potential
PRO_0000002470
Chain236 – 409174Tac AtpA intein Potential
PRO_0000002471
Chain410 – 764355V-type ATP synthase alpha chain, 2nd part Potential
PRO_0000002472

Experimental info

Sequence conflict201 – 2044PPEI → LSRD in CAB99208. Ref.1
Sequence conflict201 – 2044PPEI → LSRD in AAF88065. Ref.1
Sequence conflict209 – 2168GQRVIDAL → AQSGNRCA in CAB99208. Ref.1
Sequence conflict221 – 2266KGGTAA → EAANCR in CAB99208. Ref.1
Sequence conflict221 – 2266KGGTAA → EAANCR in AAF88065. Ref.1
Sequence conflict261 – 2677QDQKNAV → RPKERG in CAB99208. Ref.1
Sequence conflict261 – 2677QDQKNAV → RPKERG in AAF88065. Ref.1
Sequence conflict281 – 2822PL → SW in CAB99208. Ref.1
Sequence conflict281 – 2822PL → SW in AAF88065. Ref.1
Sequence conflict2951S → T in CAB99208. Ref.1
Sequence conflict2951S → T in AAF88065. Ref.1
Sequence conflict2951S → T in BAB00608. Ref.1
Sequence conflict3101T → N in CAB99208. Ref.1
Sequence conflict3101T → N in AAF88065. Ref.1
Sequence conflict3101T → N in BAB00608. Ref.1
Sequence conflict351 – 3522CA → WP in CAB99208. Ref.1
Sequence conflict351 – 3522CA → WP in AAF88065. Ref.1
Sequence conflict458 – 4625DRTVL → TGLSF in CAB99208. Ref.1
Sequence conflict458 – 4625DRTVL → TGLSF in AAF88065. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9P997 [UniParc].

Last modified January 24, 2001. Version 2.
Checksum: F1CF0EF37770306E

FASTA76484,825
        10         20         30         40         50         60 
MGKIIRISGP VVVAEDVEDA KMYDVVKVGE MGLIGEIIKI EGNRSTIQVY EDTAGIRPDE 

        70         80         90        100        110        120 
KVENTRRPLS VELGPGILKS IYDGIQRPLD VIKITSGDFI ARGLNPPALD RQKKWEFVPA 

       130        140        150        160        170        180 
VKKGETVFPG QILGTVQETS LITHRIMVPE GISGKVTMIA DGEHRVEDVI ATVSGNGKSY 

       190        200        210        220        230        240 
DIQMMTTWPV RKARRVQRKL PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGD 

       250        260        270        280        290        300 
TPVLLDAGER RIGDLFMEAI QDQKNAVEIG QNEEIVRLHD PLRIYSMVGS EIVESVSHAI 

       310        320        330        340        350        360 
YHGKSNAIVT VRTENGREVR VTPVHKLFVK IGNSVIERPA SEVNEGDEIA CASVSENGDS 

       370        380        390        400        410        420 
QTVTTTLVLT FDRVVSKEMH SGVFDVYDLM VPDYGYNFIG GNGLIVLHNT VIQHQLAKWS 

       430        440        450        460        470        480 
DANIVVYIGC GERGNEMTEI LTTFPELKDP NTGQPLMDRT VLIANTSNMP VAAREASIYT 

       490        500        510        520        530        540 
GITIAEYYRD MGYDVALMAD STSRWAEALR EISGRLEEMP GEEGYPAYLG RRVSEFYERS 

       550        560        570        580        590        600 
GRARLVSPDE RYGSITVIGA VSPPGGDISE PVSQNTLRVT RVFWALDAAL ANRRHFPSIN 

       610        620        630        640        650        660 
WLNSYSLYTE DLRSWYDKNV SSEWSALRER AMEILQRESE LQEVAQLVGY DAMPEKEKSI 

       670        680        690        700        710        720 
LDVARIIRED FLQQSAFDEI DAYCSLKKQY LMLKAIMEID TYQNKALDSG ATMDNLASLA 

       730        740        750        760 
VREKLSRMKI VPEAQVESYY NDLVEEIHKE YGNFIGEKNA EASL

« Hide

References

« Hide 'large scale' references
[1]"The intein of the Thermoplasma A-ATPase A subunit: structure, evolution and expression in E. coli."
Senejani A.G., Hilario E., Gogarten J.P.
BMC Biochem. 2:13-13(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ292523 mRNA. Translation: CAB99208.1.
AF286477 mRNA. Translation: AAF88065.1.
AB045977 mRNA. Translation: BAB00608.1.
AL445063 Genomic DNA. Translation: CAC11153.1.
RefSeqNP_393482.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ9P997.
ModBaseSearch...

Protein-protein interaction databases

STRING273075.Ta0004.

Proteomic databases

PRIDEQ9P997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC11153; CAC11153; CAC11153.
GeneID1455676.
KEGGtac:Ta0004.

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000161057.
KOK02117.
OMAVHNCGER.
ProtClustDBCLSK2560425.

Family and domain databases

Gene3D1.10.1140.10. 1 hit.
HAMAPMF_00309. ATP_synth_A_arch. Divergent sequence.
InterProIPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_a/bsu_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1_bsu/V1_C.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
IPR022878. V-ATPase_su_A/alpha.
[Graphical view]
PfamPF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVATA_THEAC
AccessionPrimary (citable) accession number: Q9P997
Secondary accession number(s): Q9HM65
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Intein-containing proteins

List of intein-containing protein entries

SIMILARITY comments

Index of protein domains and families

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