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Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Cleaved into the following chain:
Alternative name(s):
Tac VMA intein
Gene namesi
Name:atpA
Ordered Locus Names:Ta0004
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000024701 – 235V-type ATP synthase alpha chain, 1st partSequence analysisAdd BLAST235
ChainiPRO_0000002471236 – 409Tac AtpA inteinSequence analysisAdd BLAST174
ChainiPRO_0000002472410 – 764V-type ATP synthase alpha chain, 2nd partSequence analysisAdd BLAST355

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PRIDEiQ9P997.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0004.

Structurei

3D structure databases

ProteinModelPortaliQ9P997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiarCOG00868. Archaea.
COG1155. LUCA.
COG1372. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiFGSGKCV.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR030934. Intein_C.
IPR006141. Intein_N.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 2 hits.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIIRISGP VVVAEDVEDA KMYDVVKVGE MGLIGEIIKI EGNRSTIQVY
60 70 80 90 100
EDTAGIRPDE KVENTRRPLS VELGPGILKS IYDGIQRPLD VIKITSGDFI
110 120 130 140 150
ARGLNPPALD RQKKWEFVPA VKKGETVFPG QILGTVQETS LITHRIMVPE
160 170 180 190 200
GISGKVTMIA DGEHRVEDVI ATVSGNGKSY DIQMMTTWPV RKARRVQRKL
210 220 230 240 250
PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGD TPVLLDAGER
260 270 280 290 300
RIGDLFMEAI QDQKNAVEIG QNEEIVRLHD PLRIYSMVGS EIVESVSHAI
310 320 330 340 350
YHGKSNAIVT VRTENGREVR VTPVHKLFVK IGNSVIERPA SEVNEGDEIA
360 370 380 390 400
CASVSENGDS QTVTTTLVLT FDRVVSKEMH SGVFDVYDLM VPDYGYNFIG
410 420 430 440 450
GNGLIVLHNT VIQHQLAKWS DANIVVYIGC GERGNEMTEI LTTFPELKDP
460 470 480 490 500
NTGQPLMDRT VLIANTSNMP VAAREASIYT GITIAEYYRD MGYDVALMAD
510 520 530 540 550
STSRWAEALR EISGRLEEMP GEEGYPAYLG RRVSEFYERS GRARLVSPDE
560 570 580 590 600
RYGSITVIGA VSPPGGDISE PVSQNTLRVT RVFWALDAAL ANRRHFPSIN
610 620 630 640 650
WLNSYSLYTE DLRSWYDKNV SSEWSALRER AMEILQRESE LQEVAQLVGY
660 670 680 690 700
DAMPEKEKSI LDVARIIRED FLQQSAFDEI DAYCSLKKQY LMLKAIMEID
710 720 730 740 750
TYQNKALDSG ATMDNLASLA VREKLSRMKI VPEAQVESYY NDLVEEIHKE
760
YGNFIGEKNA EASL
Length:764
Mass (Da):84,825
Last modified:January 24, 2001 - v2
Checksum:iF1CF0EF37770306E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201 – 204PPEI → LSRD in CAB99208 (PubMed:11722801).Curated4
Sequence conflicti201 – 204PPEI → LSRD in AAF88065 (PubMed:11722801).Curated4
Sequence conflicti209 – 216GQRVIDAL → AQSGNRCA in CAB99208 (PubMed:11722801).Curated8
Sequence conflicti221 – 226KGGTAA → EAANCR in CAB99208 (PubMed:11722801).Curated6
Sequence conflicti221 – 226KGGTAA → EAANCR in AAF88065 (PubMed:11722801).Curated6
Sequence conflicti261 – 267QDQKNAV → RPKERG in CAB99208 (PubMed:11722801).Curated7
Sequence conflicti261 – 267QDQKNAV → RPKERG in AAF88065 (PubMed:11722801).Curated7
Sequence conflicti281 – 282PL → SW in CAB99208 (PubMed:11722801).Curated2
Sequence conflicti281 – 282PL → SW in AAF88065 (PubMed:11722801).Curated2
Sequence conflicti295S → T in CAB99208 (PubMed:11722801).Curated1
Sequence conflicti295S → T in AAF88065 (PubMed:11722801).Curated1
Sequence conflicti295S → T in BAB00608 (PubMed:11722801).Curated1
Sequence conflicti310T → N in CAB99208 (PubMed:11722801).Curated1
Sequence conflicti310T → N in AAF88065 (PubMed:11722801).Curated1
Sequence conflicti310T → N in BAB00608 (PubMed:11722801).Curated1
Sequence conflicti351 – 352CA → WP in CAB99208 (PubMed:11722801).Curated2
Sequence conflicti351 – 352CA → WP in AAF88065 (PubMed:11722801).Curated2
Sequence conflicti458 – 462DRTVL → TGLSF in CAB99208 (PubMed:11722801).Curated5
Sequence conflicti458 – 462DRTVL → TGLSF in AAF88065 (PubMed:11722801).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292523 mRNA. Translation: CAB99208.1.
AF286477 mRNA. Translation: AAF88065.1.
AB045977 mRNA. Translation: BAB00608.1.
AL445063 Genomic DNA. Translation: CAC11153.1.
RefSeqiWP_010900431.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11153; CAC11153; CAC11153.
GeneIDi1455676.
KEGGitac:Ta0004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292523 mRNA. Translation: CAB99208.1.
AF286477 mRNA. Translation: AAF88065.1.
AB045977 mRNA. Translation: BAB00608.1.
AL445063 Genomic DNA. Translation: CAC11153.1.
RefSeqiWP_010900431.1. NC_002578.1.

3D structure databases

ProteinModelPortaliQ9P997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0004.

Proteomic databases

PRIDEiQ9P997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11153; CAC11153; CAC11153.
GeneIDi1455676.
KEGGitac:Ta0004.

Phylogenomic databases

eggNOGiarCOG00868. Archaea.
COG1155. LUCA.
COG1372. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiFGSGKCV.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR030934. Intein_C.
IPR006141. Intein_N.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 2 hits.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATA_THEAC
AccessioniPrimary (citable) accession number: Q9P997
Secondary accession number(s): Q9HM65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The intein interrupts the ATP-binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.