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Q9P997

- VATA_THEAC

UniProt

Q9P997 - VATA_THEAC

Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. intein-mediated protein splicing Source: InterPro
    3. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type ATP synthase alpha chain (EC:3.6.3.14)
    Alternative name(s):
    V-ATPase subunit A
    Cleaved into the following chain:
    Alternative name(s):
    Tac VMA intein
    Gene namesi
    Name:atpA
    Ordered Locus Names:Ta0004
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235V-type ATP synthase alpha chain, 1st partSequence AnalysisPRO_0000002470Add
    BLAST
    Chaini236 – 409174Tac AtpA inteinSequence AnalysisPRO_0000002471Add
    BLAST
    Chaini410 – 764355V-type ATP synthase alpha chain, 2nd partSequence AnalysisPRO_0000002472Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Proteomic databases

    PRIDEiQ9P997.

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta0004.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P997.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000161057.
    KOiK02117.
    OMAiVHNCGER.

    Family and domain databases

    Gene3Di1.10.1140.10. 1 hit.
    2.170.16.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPiMF_00309. ATP_synth_A_arch.
    InterProiIPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 2 hits.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view]
    SMARTiSM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF51294. SSF51294. 1 hit.
    SSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P997-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKIIRISGP VVVAEDVEDA KMYDVVKVGE MGLIGEIIKI EGNRSTIQVY    50
    EDTAGIRPDE KVENTRRPLS VELGPGILKS IYDGIQRPLD VIKITSGDFI 100
    ARGLNPPALD RQKKWEFVPA VKKGETVFPG QILGTVQETS LITHRIMVPE 150
    GISGKVTMIA DGEHRVEDVI ATVSGNGKSY DIQMMTTWPV RKARRVQRKL 200
    PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGD TPVLLDAGER 250
    RIGDLFMEAI QDQKNAVEIG QNEEIVRLHD PLRIYSMVGS EIVESVSHAI 300
    YHGKSNAIVT VRTENGREVR VTPVHKLFVK IGNSVIERPA SEVNEGDEIA 350
    CASVSENGDS QTVTTTLVLT FDRVVSKEMH SGVFDVYDLM VPDYGYNFIG 400
    GNGLIVLHNT VIQHQLAKWS DANIVVYIGC GERGNEMTEI LTTFPELKDP 450
    NTGQPLMDRT VLIANTSNMP VAAREASIYT GITIAEYYRD MGYDVALMAD 500
    STSRWAEALR EISGRLEEMP GEEGYPAYLG RRVSEFYERS GRARLVSPDE 550
    RYGSITVIGA VSPPGGDISE PVSQNTLRVT RVFWALDAAL ANRRHFPSIN 600
    WLNSYSLYTE DLRSWYDKNV SSEWSALRER AMEILQRESE LQEVAQLVGY 650
    DAMPEKEKSI LDVARIIRED FLQQSAFDEI DAYCSLKKQY LMLKAIMEID 700
    TYQNKALDSG ATMDNLASLA VREKLSRMKI VPEAQVESYY NDLVEEIHKE 750
    YGNFIGEKNA EASL 764
    Length:764
    Mass (Da):84,825
    Last modified:January 24, 2001 - v2
    Checksum:iF1CF0EF37770306E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti201 – 2044PPEI → LSRD in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti201 – 2044PPEI → LSRD in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti209 – 2168GQRVIDAL → AQSGNRCA in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti221 – 2266KGGTAA → EAANCR in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti221 – 2266KGGTAA → EAANCR in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti261 – 2677QDQKNAV → RPKERG in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti261 – 2677QDQKNAV → RPKERG in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti281 – 2822PL → SW in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti281 – 2822PL → SW in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti295 – 2951S → T in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti295 – 2951S → T in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti295 – 2951S → T in BAB00608. (PubMed:11722801)Curated
    Sequence conflicti310 – 3101T → N in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti310 – 3101T → N in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti310 – 3101T → N in BAB00608. (PubMed:11722801)Curated
    Sequence conflicti351 – 3522CA → WP in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti351 – 3522CA → WP in AAF88065. (PubMed:11722801)Curated
    Sequence conflicti458 – 4625DRTVL → TGLSF in CAB99208. (PubMed:11722801)Curated
    Sequence conflicti458 – 4625DRTVL → TGLSF in AAF88065. (PubMed:11722801)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ292523 mRNA. Translation: CAB99208.1.
    AF286477 mRNA. Translation: AAF88065.1.
    AB045977 mRNA. Translation: BAB00608.1.
    AL445063 Genomic DNA. Translation: CAC11153.1.
    RefSeqiNP_393482.1. NC_002578.1.
    WP_010900431.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC11153; CAC11153; CAC11153.
    GeneIDi1455676.
    KEGGitac:Ta0004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ292523 mRNA. Translation: CAB99208.1 .
    AF286477 mRNA. Translation: AAF88065.1 .
    AB045977 mRNA. Translation: BAB00608.1 .
    AL445063 Genomic DNA. Translation: CAC11153.1 .
    RefSeqi NP_393482.1. NC_002578.1.
    WP_010900431.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9P997.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta0004.

    Proteomic databases

    PRIDEi Q9P997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC11153 ; CAC11153 ; CAC11153 .
    GeneIDi 1455676.
    KEGGi tac:Ta0004.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000161057.
    KOi K02117.
    OMAi VHNCGER.

    Family and domain databases

    Gene3Di 1.10.1140.10. 1 hit.
    2.170.16.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPi MF_00309. ATP_synth_A_arch.
    InterProi IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 2 hits.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view ]
    SMARTi SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF51294. SSF51294. 1 hit.
    SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The intein of the Thermoplasma A-ATPase A subunit: structure, evolution and expression in E. coli."
      Senejani A.G., Hilario E., Gogarten J.P.
      BMC Biochem. 2:13-13(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiVATA_THEAC
    AccessioniPrimary (citable) accession number: Q9P997
    Secondary accession number(s): Q9HM65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The intein interrupts the ATP-binding site.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3