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Q9P997

- VATA_THEAC

UniProt

Q9P997 - VATA_THEAC

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Protein

V-type ATP synthase alpha chain

Gene
atpA, Ta0004
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. intein-mediated protein splicing Source: InterPro
  3. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Cleaved into the following chain:
Alternative name(s):
Tac VMA intein
Gene namesi
Name:atpA
Ordered Locus Names:Ta0004
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235V-type ATP synthase alpha chain, 1st part Reviewed predictionPRO_0000002470Add
BLAST
Chaini236 – 409174Tac AtpA intein Reviewed predictionPRO_0000002471Add
BLAST
Chaini410 – 764355V-type ATP synthase alpha chain, 2nd part Reviewed predictionPRO_0000002472Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation Reviewed prediction.UniRule annotation

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PRIDEiQ9P997.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0004.

Structurei

3D structure databases

ProteinModelPortaliQ9P997.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000161057.
KOiK02117.
OMAiVHNCGER.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P997-1 [UniParc]FASTAAdd to Basket

« Hide

MGKIIRISGP VVVAEDVEDA KMYDVVKVGE MGLIGEIIKI EGNRSTIQVY    50
EDTAGIRPDE KVENTRRPLS VELGPGILKS IYDGIQRPLD VIKITSGDFI 100
ARGLNPPALD RQKKWEFVPA VKKGETVFPG QILGTVQETS LITHRIMVPE 150
GISGKVTMIA DGEHRVEDVI ATVSGNGKSY DIQMMTTWPV RKARRVQRKL 200
PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGD TPVLLDAGER 250
RIGDLFMEAI QDQKNAVEIG QNEEIVRLHD PLRIYSMVGS EIVESVSHAI 300
YHGKSNAIVT VRTENGREVR VTPVHKLFVK IGNSVIERPA SEVNEGDEIA 350
CASVSENGDS QTVTTTLVLT FDRVVSKEMH SGVFDVYDLM VPDYGYNFIG 400
GNGLIVLHNT VIQHQLAKWS DANIVVYIGC GERGNEMTEI LTTFPELKDP 450
NTGQPLMDRT VLIANTSNMP VAAREASIYT GITIAEYYRD MGYDVALMAD 500
STSRWAEALR EISGRLEEMP GEEGYPAYLG RRVSEFYERS GRARLVSPDE 550
RYGSITVIGA VSPPGGDISE PVSQNTLRVT RVFWALDAAL ANRRHFPSIN 600
WLNSYSLYTE DLRSWYDKNV SSEWSALRER AMEILQRESE LQEVAQLVGY 650
DAMPEKEKSI LDVARIIRED FLQQSAFDEI DAYCSLKKQY LMLKAIMEID 700
TYQNKALDSG ATMDNLASLA VREKLSRMKI VPEAQVESYY NDLVEEIHKE 750
YGNFIGEKNA EASL 764
Length:764
Mass (Da):84,825
Last modified:January 24, 2001 - v2
Checksum:iF1CF0EF37770306E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2044PPEI → LSRD in CAB99208. 1 Publication
Sequence conflicti201 – 2044PPEI → LSRD in AAF88065. 1 Publication
Sequence conflicti209 – 2168GQRVIDAL → AQSGNRCA in CAB99208. 1 Publication
Sequence conflicti221 – 2266KGGTAA → EAANCR in CAB99208. 1 Publication
Sequence conflicti221 – 2266KGGTAA → EAANCR in AAF88065. 1 Publication
Sequence conflicti261 – 2677QDQKNAV → RPKERG in CAB99208. 1 Publication
Sequence conflicti261 – 2677QDQKNAV → RPKERG in AAF88065. 1 Publication
Sequence conflicti281 – 2822PL → SW in CAB99208. 1 Publication
Sequence conflicti281 – 2822PL → SW in AAF88065. 1 Publication
Sequence conflicti295 – 2951S → T in CAB99208. 1 Publication
Sequence conflicti295 – 2951S → T in AAF88065. 1 Publication
Sequence conflicti295 – 2951S → T in BAB00608. 1 Publication
Sequence conflicti310 – 3101T → N in CAB99208. 1 Publication
Sequence conflicti310 – 3101T → N in AAF88065. 1 Publication
Sequence conflicti310 – 3101T → N in BAB00608. 1 Publication
Sequence conflicti351 – 3522CA → WP in CAB99208. 1 Publication
Sequence conflicti351 – 3522CA → WP in AAF88065. 1 Publication
Sequence conflicti458 – 4625DRTVL → TGLSF in CAB99208. 1 Publication
Sequence conflicti458 – 4625DRTVL → TGLSF in AAF88065. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ292523 mRNA. Translation: CAB99208.1.
AF286477 mRNA. Translation: AAF88065.1.
AB045977 mRNA. Translation: BAB00608.1.
AL445063 Genomic DNA. Translation: CAC11153.1.
RefSeqiNP_393482.1. NC_002578.1.
WP_010900431.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11153; CAC11153; CAC11153.
GeneIDi1455676.
KEGGitac:Ta0004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ292523 mRNA. Translation: CAB99208.1 .
AF286477 mRNA. Translation: AAF88065.1 .
AB045977 mRNA. Translation: BAB00608.1 .
AL445063 Genomic DNA. Translation: CAC11153.1 .
RefSeqi NP_393482.1. NC_002578.1.
WP_010900431.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9P997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta0004.

Proteomic databases

PRIDEi Q9P997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC11153 ; CAC11153 ; CAC11153 .
GeneIDi 1455676.
KEGGi tac:Ta0004.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000161057.
KOi K02117.
OMAi VHNCGER.

Family and domain databases

Gene3Di 1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPi MF_00309. ATP_synth_A_arch.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SMARTi SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The intein of the Thermoplasma A-ATPase A subunit: structure, evolution and expression in E. coli."
    Senejani A.G., Hilario E., Gogarten J.P.
    BMC Biochem. 2:13-13(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiVATA_THEAC
AccessioniPrimary (citable) accession number: Q9P997
Secondary accession number(s): Q9HM65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The intein interrupts the ATP-binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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