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Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (TPI1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Binding sitei12SubstrateBy similarity1
Active sitei95ElectrophileBy similarity1
Active sitei165Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • gluconeogenesis Source: UniProtKB-UniPathway
  • glycolytic process Source: UniProtKB-UniPathway
  • induction by symbiont of host defense response Source: CGD
  • pentose-phosphate shunt Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI1
ORF Names:CaO19.14037, CaO19.6745
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000173961. TPI1.

Subcellular locationi

GO - Cellular componenti

  • biofilm matrix Source: CGD
  • cell surface Source: CGD
  • cytoplasm Source: UniProtKB-SubCell
  • fungal-type cell wall Source: CGD
  • hyphal cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000901582 – 248Triosephosphate isomeraseAdd BLAST247

Proteomic databases

PRIDEiQ9P940.

2D gel databases

COMPLUYEAST-2DPAGEP82613.
Q9P940.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9P940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

InParanoidiQ9P940.
KOiK01803.
OrthoDBiEOG092C484E.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARQFFVGGN FKANGTKQQI TSIIDNLNKA DLPKDVEVVI CPPALYLGLA
60 70 80 90 100
VEQNKQPTVA IGAQNVFDKS CGAFTGETCA SQILDVGASW TLTGHSERRT
110 120 130 140 150
IIKESDEFIA EKTKFALDTG VKVILCIGET LEERKGGVTL DVCARQLDAV
160 170 180 190 200
SKIVSDWSNI VVAYEPVWAI GTGLAATPED AEETHKGIRA HLAKSIGAEQ
210 220 230 240
AEKTRILYGG SVNGKNAKDF KDKANVDGFL VGGASLKPEF VDIIKSRL
Length:248
Mass (Da):26,611
Last modified:January 23, 2007 - v3
Checksum:i732EBBFE55BB7A10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195S → T in CAB77631 (PubMed:11231556).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ390491 mRNA. Translation: CAB77631.1.
AF124845 Genomic DNA. Translation: AAF28895.1.
AACQ01000028 Genomic DNA. Translation: EAL00977.1.
AACQ01000029 Genomic DNA. Translation: EAL00852.1.
RefSeqiXP_719725.1. XM_714632.1.
XP_719842.1. XM_714749.1.

Genome annotation databases

EnsemblFungiiEAL00852; EAL00852; CaO19.14037.
EAL00977; EAL00977; CaO19.6745.
GeneIDi3638482.
3638579.
KEGGical:CaO19.14037.
cal:CaO19.6745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ390491 mRNA. Translation: CAB77631.1.
AF124845 Genomic DNA. Translation: AAF28895.1.
AACQ01000028 Genomic DNA. Translation: EAL00977.1.
AACQ01000029 Genomic DNA. Translation: EAL00852.1.
RefSeqiXP_719725.1. XM_714632.1.
XP_719842.1. XM_714749.1.

3D structure databases

ProteinModelPortaliQ9P940.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEP82613.
Q9P940.

Proteomic databases

PRIDEiQ9P940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL00852; EAL00852; CaO19.14037.
EAL00977; EAL00977; CaO19.6745.
GeneIDi3638482.
3638579.
KEGGical:CaO19.14037.
cal:CaO19.6745.

Organism-specific databases

CGDiCAL0000173961. TPI1.

Phylogenomic databases

InParanoidiQ9P940.
KOiK01803.
OrthoDBiEOG092C484E.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_CANAL
AccessioniPrimary (citable) accession number: Q9P940
Secondary accession number(s): P82613, Q5ADU6, Q9P848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties.
Critical for growth.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.