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Q9P940

- TPIS_CANAL

UniProt

Q9P940 - TPIS_CANAL

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Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101SubstrateBy similarity
Binding sitei12 – 121SubstrateBy similarity
Active sitei95 – 951ElectrophileBy similarity
Active sitei165 – 1651Proton acceptorBy similarity

GO - Molecular functioni

  1. triose-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to starvation Source: CGD
  2. filamentous growth Source: CGD
  3. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  4. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  5. gluconeogenesis Source: UniProtKB-UniPathway
  6. glycolytic process Source: UniProtKB-UniPathway
  7. induction by symbiont of host defense response Source: CGD
  8. pentose-phosphate shunt Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI1
ORF Names:CaO19.14037, CaO19.6745
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004861. TPI1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cell surface Source: CGD
  2. cytoplasm Source: UniProtKB-KW
  3. fungal-type cell wall Source: CGD
  4. hyphal cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 248247Triosephosphate isomerasePRO_0000090158Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP82613.
Q9P940.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0004861.

Structurei

3D structure databases

ProteinModelPortaliQ9P940.
SMRiQ9P940. Positions 2-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

eggNOGiCOG0149.
InParanoidiQ9P940.
KOiK01803.
OrthoDBiEOG79W9GP.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P940-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARQFFVGGN FKANGTKQQI TSIIDNLNKA DLPKDVEVVI CPPALYLGLA
60 70 80 90 100
VEQNKQPTVA IGAQNVFDKS CGAFTGETCA SQILDVGASW TLTGHSERRT
110 120 130 140 150
IIKESDEFIA EKTKFALDTG VKVILCIGET LEERKGGVTL DVCARQLDAV
160 170 180 190 200
SKIVSDWSNI VVAYEPVWAI GTGLAATPED AEETHKGIRA HLAKSIGAEQ
210 220 230 240
AEKTRILYGG SVNGKNAKDF KDKANVDGFL VGGASLKPEF VDIIKSRL
Length:248
Mass (Da):26,611
Last modified:January 23, 2007 - v3
Checksum:i732EBBFE55BB7A10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951S → T in CAB77631. (PubMed:11231556)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ390491 mRNA. Translation: CAB77631.1.
AF124845 Genomic DNA. Translation: AAF28895.1.
AACQ01000028 Genomic DNA. Translation: EAL00977.1.
AACQ01000029 Genomic DNA. Translation: EAL00852.1.
RefSeqiXP_719725.1. XM_714632.1.
XP_719842.1. XM_714749.1.

Genome annotation databases

GeneIDi3638482.
3638579.
KEGGical:CaO19.14037.
cal:CaO19.6745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ390491 mRNA. Translation: CAB77631.1 .
AF124845 Genomic DNA. Translation: AAF28895.1 .
AACQ01000028 Genomic DNA. Translation: EAL00977.1 .
AACQ01000029 Genomic DNA. Translation: EAL00852.1 .
RefSeqi XP_719725.1. XM_714632.1.
XP_719842.1. XM_714749.1.

3D structure databases

ProteinModelPortali Q9P940.
SMRi Q9P940. Positions 2-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0004861.

2D gel databases

COMPLUYEAST-2DPAGE P82613.
Q9P940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3638482.
3638579.
KEGGi cal:CaO19.14037.
cal:CaO19.6745.

Organism-specific databases

CGDi CAL0004861. TPI1.

Phylogenomic databases

eggNOGi COG0149.
InParanoidi Q9P940.
KOi K01803.
OrthoDBi EOG79W9GP.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00189 .
UPA00138 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00147_B. TIM_B.
InterProi IPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view ]
PANTHERi PTHR21139. PTHR21139. 1 hit.
Pfami PF00121. TIM. 1 hit.
[Graphical view ]
SUPFAMi SSF51351. SSF51351. 1 hit.
TIGRFAMsi TIGR00419. tim. 1 hit.
PROSITEi PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans."
    De Backer M.D., Nelissen B., Logghe M., Viaene J., Loonen I., Vandoninck S., de Hoogt R., Dewaele S., Simons F.A., Verhasselt P., Vanhoof G., Contreras R., Luyten W.H.M.L.
    Nat. Biotechnol. 19:235-241(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domain."
    Hoyer L.L., Hecht J.E.
    Yeast 18:49-60(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1161.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  4. "Analysis of the serologic response to systemic Candida albicans infection in a murine model."
    Pitarch A., Diez-Orejas R., Molero G., Pardo M., Sanchez M., Gil C., Nombela C.
    Proteomics 1:550-559(2001)
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Strain: SC5314 / ATCC MYA-2876.
  5. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 123-134 AND 139-145, SUBCELLULAR LOCATION, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiTPIS_CANAL
AccessioniPrimary (citable) accession number: Q9P940
Secondary accession number(s): P82613, Q5ADU6, Q9P848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties.
Critical for growth.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3