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Q9P940 (TPIS_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triosephosphate isomerase

Short name=TIM
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase
Gene names
Name:TPI1
ORF Names:CaO19.14037, CaO19.6745
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147_B

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147_B

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147_B

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00147_B

Subcellular location

Cytoplasm Ref.5.

Miscellaneous

Has antigenic properties.

Critical for growth.

Sequence similarities

Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to starvation

Inferred from mutant phenotype PubMed 12773383. Source: CGD

filamentous growth

Inferred from mutant phenotype PubMed 12773383. Source: CGD

filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype PubMed 12773383. Source: CGD

filamentous growth of a population of unicellular organisms in response to starvation

Inferred from mutant phenotype PubMed 12773383. Source: CGD

gluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

induction by symbiont of host defense response

Inferred from direct assay PubMed 11681208. Source: CGD

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell surface

Inferred from direct assay PubMed 12543933. Source: CGD

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

fungal-type cell wall

Inferred from direct assay PubMed 16195222PubMed 18369901. Source: CGD

hyphal cell wall

Inferred from direct assay PubMed 1383159. Source: CGD

   Molecular_functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 248247Triosephosphate isomerase HAMAP-Rule MF_00147_B
PRO_0000090158

Sites

Active site951Electrophile By similarity
Active site1651Proton acceptor By similarity
Binding site101Substrate By similarity
Binding site121Substrate By similarity

Experimental info

Sequence conflict1951S → T in CAB77631. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9P940 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 732EBBFE55BB7A10

FASTA24826,611
        10         20         30         40         50         60 
MARQFFVGGN FKANGTKQQI TSIIDNLNKA DLPKDVEVVI CPPALYLGLA VEQNKQPTVA 

        70         80         90        100        110        120 
IGAQNVFDKS CGAFTGETCA SQILDVGASW TLTGHSERRT IIKESDEFIA EKTKFALDTG 

       130        140        150        160        170        180 
VKVILCIGET LEERKGGVTL DVCARQLDAV SKIVSDWSNI VVAYEPVWAI GTGLAATPED 

       190        200        210        220        230        240 
AEETHKGIRA HLAKSIGAEQ AEKTRILYGG SVNGKNAKDF KDKANVDGFL VGGASLKPEF 


VDIIKSRL 

« Hide

References

« Hide 'large scale' references
[1]"An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans."
De Backer M.D., Nelissen B., Logghe M., Viaene J., Loonen I., Vandoninck S., de Hoogt R., Dewaele S., Simons F.A., Verhasselt P., Vanhoof G., Contreras R., Luyten W.H.M.L.
Nat. Biotechnol. 19:235-241(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domain."
Hoyer L.L., Hecht J.E.
Yeast 18:49-60(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1161.
[3]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[4]"Analysis of the serologic response to systemic Candida albicans infection in a murine model."
Pitarch A., Diez-Orejas R., Molero G., Pardo M., Sanchez M., Gil C., Nombela C.
Proteomics 1:550-559(2001)
Cited for: PROTEIN SEQUENCE OF 2-11.
Strain: SC5314 / ATCC MYA-2876.
[5]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 123-134 AND 139-145, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ390491 mRNA. Translation: CAB77631.1.
AF124845 Genomic DNA. Translation: AAF28895.1.
AACQ01000028 Genomic DNA. Translation: EAL00977.1.
AACQ01000029 Genomic DNA. Translation: EAL00852.1.
RefSeqXP_719725.1. XM_714632.1.
XP_719842.1. XM_714749.1.

3D structure databases

ProteinModelPortalQ9P940.
SMRQ9P940. Positions 2-247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004861.

2D gel databases

COMPLUYEAST-2DPAGEP82613.
Q9P940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3638482.
3638579.
KEGGcal:CaO19.14037.
cal:CaO19.6745.

Organism-specific databases

CGDCAL0004861. TPI1.

Phylogenomic databases

eggNOGCOG0149.
KOK01803.
OrthoDBEOG79W9GP.

Enzyme and pathway databases

UniPathwayUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00147_B. TIM_B.
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERPTHR21139. PTHR21139. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. SSF51351. 1 hit.
TIGRFAMsTIGR00419. tim. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPIS_CANAL
AccessionPrimary (citable) accession number: Q9P940
Secondary accession number(s): P82613, Q5ADU6, Q9P848
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names