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Q9P940

- TPIS_CANAL

UniProt

Q9P940 - TPIS_CANAL

Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate = glycerone phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101SubstrateBy similarity
    Binding sitei12 – 121SubstrateBy similarity
    Active sitei95 – 951ElectrophileBy similarity
    Active sitei165 – 1651Proton acceptorBy similarity

    GO - Molecular functioni

    1. triose-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to starvation Source: CGD
    2. filamentous growth Source: CGD
    3. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    4. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    5. gluconeogenesis Source: UniProtKB-UniPathway
    6. glycolytic process Source: UniProtKB-UniPathway
    7. induction by symbiont of host defense response Source: CGD
    8. pentose-phosphate shunt Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis, Pentose shunt

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00189.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triosephosphate isomerase (EC:5.3.1.1)
    Short name:
    TIM
    Alternative name(s):
    Triose-phosphate isomerase
    Gene namesi
    Name:TPI1
    ORF Names:CaO19.14037, CaO19.6745
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004861. TPI1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cell surface Source: CGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. fungal-type cell wall Source: CGD
    4. hyphal cell wall Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 248247Triosephosphate isomerasePRO_0000090158Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP82613.
    Q9P940.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0004861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P940.
    SMRiQ9P940. Positions 2-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the triosephosphate isomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG0149.
    KOiK01803.
    OrthoDBiEOG79W9GP.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00147_B. TIM_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view]
    PANTHERiPTHR21139. PTHR21139. 1 hit.
    PfamiPF00121. TIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF51351. SSF51351. 1 hit.
    TIGRFAMsiTIGR00419. tim. 1 hit.
    PROSITEiPS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARQFFVGGN FKANGTKQQI TSIIDNLNKA DLPKDVEVVI CPPALYLGLA    50
    VEQNKQPTVA IGAQNVFDKS CGAFTGETCA SQILDVGASW TLTGHSERRT 100
    IIKESDEFIA EKTKFALDTG VKVILCIGET LEERKGGVTL DVCARQLDAV 150
    SKIVSDWSNI VVAYEPVWAI GTGLAATPED AEETHKGIRA HLAKSIGAEQ 200
    AEKTRILYGG SVNGKNAKDF KDKANVDGFL VGGASLKPEF VDIIKSRL 248
    Length:248
    Mass (Da):26,611
    Last modified:January 23, 2007 - v3
    Checksum:i732EBBFE55BB7A10
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951S → T in CAB77631. (PubMed:11231556)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ390491 mRNA. Translation: CAB77631.1.
    AF124845 Genomic DNA. Translation: AAF28895.1.
    AACQ01000028 Genomic DNA. Translation: EAL00977.1.
    AACQ01000029 Genomic DNA. Translation: EAL00852.1.
    RefSeqiXP_719725.1. XM_714632.1.
    XP_719842.1. XM_714749.1.

    Genome annotation databases

    GeneIDi3638482.
    3638579.
    KEGGical:CaO19.14037.
    cal:CaO19.6745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ390491 mRNA. Translation: CAB77631.1 .
    AF124845 Genomic DNA. Translation: AAF28895.1 .
    AACQ01000028 Genomic DNA. Translation: EAL00977.1 .
    AACQ01000029 Genomic DNA. Translation: EAL00852.1 .
    RefSeqi XP_719725.1. XM_714632.1.
    XP_719842.1. XM_714749.1.

    3D structure databases

    ProteinModelPortali Q9P940.
    SMRi Q9P940. Positions 2-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0004861.

    2D gel databases

    COMPLUYEAST-2DPAGE P82613.
    Q9P940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3638482.
    3638579.
    KEGGi cal:CaO19.14037.
    cal:CaO19.6745.

    Organism-specific databases

    CGDi CAL0004861. TPI1.

    Phylogenomic databases

    eggNOGi COG0149.
    KOi K01803.
    OrthoDBi EOG79W9GP.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00189 .
    UPA00138 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00147_B. TIM_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view ]
    PANTHERi PTHR21139. PTHR21139. 1 hit.
    Pfami PF00121. TIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51351. SSF51351. 1 hit.
    TIGRFAMsi TIGR00419. tim. 1 hit.
    PROSITEi PS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans."
      De Backer M.D., Nelissen B., Logghe M., Viaene J., Loonen I., Vandoninck S., de Hoogt R., Dewaele S., Simons F.A., Verhasselt P., Vanhoof G., Contreras R., Luyten W.H.M.L.
      Nat. Biotechnol. 19:235-241(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domain."
      Hoyer L.L., Hecht J.E.
      Yeast 18:49-60(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 1161.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    4. "Analysis of the serologic response to systemic Candida albicans infection in a murine model."
      Pitarch A., Diez-Orejas R., Molero G., Pardo M., Sanchez M., Gil C., Nombela C.
      Proteomics 1:550-559(2001)
      Cited for: PROTEIN SEQUENCE OF 2-11.
      Strain: SC5314 / ATCC MYA-2876.
    5. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 123-134 AND 139-145, SUBCELLULAR LOCATION, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiTPIS_CANAL
    AccessioniPrimary (citable) accession number: Q9P940
    Secondary accession number(s): P82613, Q5ADU6, Q9P848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties.
    Critical for growth.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3