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Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Has antigenic properties.
Critical for growth.

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (TPI1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Binding sitei12SubstrateBy similarity1
Active sitei95ElectrophileBy similarity1
Active sitei165Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • gluconeogenesis Source: UniProtKB-UniPathway
  • glycolytic process Source: UniProtKB-UniPathway
  • induction by symbiont of host defense response Source: CGD

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI1
Ordered Locus Names:CAALFM_C307440WA
ORF Names:CaO19.14037, CaO19.6745
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000173961 TPI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000901582 – 248Triosephosphate isomeraseAdd BLAST247

2D gel databases

COMPLUYEAST-2DPAGEQ9P940

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9P940
SMRiQ9P940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

InParanoidiQ9P940
KOiK01803
OMAiLCVGEGL
OrthoDBiEOG092C484E

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARQFFVGGN FKANGTKQQI TSIIDNLNKA DLPKDVEVVI CPPALYLGLA
60 70 80 90 100
VEQNKQPTVA IGAQNVFDKS CGAFTGETCA SQILDVGASW TLTGHSERRT
110 120 130 140 150
IIKESDEFIA EKTKFALDTG VKVILCIGET LEERKGGVTL DVCARQLDAV
160 170 180 190 200
SKIVSDWSNI VVAYEPVWAI GTGLAATPED AEETHKGIRA HLAKSIGAEQ
210 220 230 240
AEKTRILYGG SVNGKNAKDF KDKANVDGFL VGGASLKPEF VDIIKSRL
Length:248
Mass (Da):26,611
Last modified:January 23, 2007 - v3
Checksum:i732EBBFE55BB7A10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195S → T in CAB77631 (PubMed:11231556).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ390491 mRNA Translation: CAB77631.1
AF124845 Genomic DNA Translation: AAF28895.1
CP017625 Genomic DNA Translation: AOW28746.1
RefSeqiXP_719842.1, XM_714749.1

Genome annotation databases

EnsemblFungiiAOW28746; AOW28746; CAALFM_C307440WA
GeneIDi3638482
KEGGical:CAALFM_C307440WA

Similar proteinsi

Entry informationi

Entry nameiTPIS_CANAL
AccessioniPrimary (citable) accession number: Q9P940
Secondary accession number(s): A0A1D8PKS9
, P82613, Q5ADU6, Q9P848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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