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Q9P8X9

- PYRF_AURPU

UniProt

Q9P8X9 - PYRF_AURPU

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
URA3
Organism
Aureobasidium pullulans (Black yeast) (Pullularia pullulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Substrate By similarity
Active sitei98 – 981Proton donor By similarity
Binding sitei217 – 2171Substrate By similarity
Binding sitei236 – 2361Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiAureobasidium pullulans (Black yeast) (Pullularia pullulans)
Taxonomic identifieri5580 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeDothidealesDothioraceaemitosporic DothioraceaeAureobasidium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylase
PRO_0000134645Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9P8X9.
SMRiQ9P8X9. Positions 9-261.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 673Substrate binding By similarity
Regioni96 – 10510Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P8X9-1 [UniParc]FASTAAdd to Basket

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MSRHATITQS YQERASLPKT SPVASYLLRL IAAKKTNLCV SADVSTTREL    50
LQLAEEVGDS ICMLKTHADI INDFGPRTIE GLKEIAAKKH FLVFEDRKFG 100
DIGSTVQKQF TAGPLQIVRW ANIINAHIFP GPAIITALSQ ARPRCRQLLI 150
LAEMSSAGNL MTGSYTEQCV VEARKNPEFV MGFIAQRTLN EQPGDNFITM 200
TPGVQIGATG DGLGQQYNTP EKVIGEAGTD IIIVGRGVYG AQDKRAKAEE 250
YRVRAWKAYE GNWRCYCNKR 270
Length:270
Mass (Da):29,840
Last modified:October 1, 2000 - v1
Checksum:iE6C96116CA78B18D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF165169 Genomic DNA. Translation: AAF60964.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF165169 Genomic DNA. Translation: AAF60964.1 .

3D structure databases

ProteinModelPortali Q9P8X9.
SMRi Q9P8X9. Positions 9-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of the Aureobasidium pullulans ura3 gene encoding orotidine-5'-phosphate decarboxylase and isolation of mutants defective in this gene."
    Rose K., Liebergesell M., Steinbuechel A.
    Appl. Microbiol. Biotechnol. 53:296-300(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 591.75.

Entry informationi

Entry nameiPYRF_AURPU
AccessioniPrimary (citable) accession number: Q9P8X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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