Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9P8X9

- PYRF_AURPU

UniProt

Q9P8X9 - PYRF_AURPU

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Aureobasidium pullulans (Black yeast) (Pullularia pullulans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431SubstrateBy similarity
    Active sitei98 – 981Proton donorPROSITE-ProRule annotation
    Binding sitei217 – 2171SubstrateBy similarity
    Binding sitei236 – 2361SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    OrganismiAureobasidium pullulans (Black yeast) (Pullularia pullulans)
    Taxonomic identifieri5580 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeDothidealesDothioraceaemitosporic DothioraceaeAureobasidium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_0000134645Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P8X9.
    SMRiQ9P8X9. Positions 9-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni65 – 673Substrate bindingBy similarity
    Regioni96 – 10510Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P8X9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRHATITQS YQERASLPKT SPVASYLLRL IAAKKTNLCV SADVSTTREL    50
    LQLAEEVGDS ICMLKTHADI INDFGPRTIE GLKEIAAKKH FLVFEDRKFG 100
    DIGSTVQKQF TAGPLQIVRW ANIINAHIFP GPAIITALSQ ARPRCRQLLI 150
    LAEMSSAGNL MTGSYTEQCV VEARKNPEFV MGFIAQRTLN EQPGDNFITM 200
    TPGVQIGATG DGLGQQYNTP EKVIGEAGTD IIIVGRGVYG AQDKRAKAEE 250
    YRVRAWKAYE GNWRCYCNKR 270
    Length:270
    Mass (Da):29,840
    Last modified:October 1, 2000 - v1
    Checksum:iE6C96116CA78B18D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF165169 Genomic DNA. Translation: AAF60964.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF165169 Genomic DNA. Translation: AAF60964.1 .

    3D structure databases

    ProteinModelPortali Q9P8X9.
    SMRi Q9P8X9. Positions 9-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the Aureobasidium pullulans ura3 gene encoding orotidine-5'-phosphate decarboxylase and isolation of mutants defective in this gene."
      Rose K., Liebergesell M., Steinbuechel A.
      Appl. Microbiol. Biotechnol. 53:296-300(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CBS 591.75.

    Entry informationi

    Entry nameiPYRF_AURPU
    AccessioniPrimary (citable) accession number: Q9P8X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3