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Q9P8X9 (PYRF_AURPU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismAureobasidium pullulans (Black yeast) (Pullularia pullulans)
Taxonomic identifier5580 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeDothidealesDothioraceaemitosporic DothioraceaeAureobasidium

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Orotidine 5'-phosphate decarboxylase
PRO_0000134645

Regions

Region65 – 673Substrate binding By similarity
Region96 – 10510Substrate binding By similarity

Sites

Active site981Proton donor By similarity
Binding site431Substrate By similarity
Binding site2171Substrate By similarity
Binding site2361Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9P8X9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: E6C96116CA78B18D

FASTA27029,840
        10         20         30         40         50         60 
MSRHATITQS YQERASLPKT SPVASYLLRL IAAKKTNLCV SADVSTTREL LQLAEEVGDS 

        70         80         90        100        110        120 
ICMLKTHADI INDFGPRTIE GLKEIAAKKH FLVFEDRKFG DIGSTVQKQF TAGPLQIVRW 

       130        140        150        160        170        180 
ANIINAHIFP GPAIITALSQ ARPRCRQLLI LAEMSSAGNL MTGSYTEQCV VEARKNPEFV 

       190        200        210        220        230        240 
MGFIAQRTLN EQPGDNFITM TPGVQIGATG DGLGQQYNTP EKVIGEAGTD IIIVGRGVYG 

       250        260        270 
AQDKRAKAEE YRVRAWKAYE GNWRCYCNKR 

« Hide

References

[1]"Molecular analysis of the Aureobasidium pullulans ura3 gene encoding orotidine-5'-phosphate decarboxylase and isolation of mutants defective in this gene."
Rose K., Liebergesell M., Steinbuechel A.
Appl. Microbiol. Biotechnol. 53:296-300(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 591.75.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF165169 Genomic DNA. Translation: AAF60964.1.

3D structure databases

ProteinModelPortalQ9P8X9.
SMRQ9P8X9. Positions 9-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_AURPU
AccessionPrimary (citable) accession number: Q9P8X9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways