Reviewed, UniProtKB/Swiss-Prot Q9P8W5 (LIP2_CANAL)

Names and origin

Protein names

Recommended name:
    Lipase 2
    EC=3.1.1.3

Gene names

Name:

LIP2

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted. Ref.1
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 466	450	Lipase 2		PRO_0000017821
Sites
	Active site	196	1	Charge relay system By similarity
	Active site	344	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	319	1	N-linked (GlcNAc...) Potential
	Glycosylation	331	1	N-linked (GlcNAc...) Potential
	Glycosylation	422	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P8W5-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C4F4C994B761F42C	FASTA	466	50,422
	10 20 30 40 50 60 MKGLVFLLGL LPTIYASLVH ITPASEDDFY NPPAGFESAK NGDILKLRNS PNRLASFYFP 70 80 90 100 110 120 IDVKNAWQLL VKSEDSFGNP NAFVTTLIEP YNADPSKVVS YQTWEDASNI NCSPSYGAQF 130 140 150 160 170 180 GSPLSTITTQ IDMTLIVPPL RSGYYVVTPD YEGPKATFAV GRQSGQATLD SVRAILKSGS 190 200 210 220 230 240 FSGINEDAKV ALWGYSGGSL ATGWAAALQP VYAPELQKNI VGAAVGGFAA NITAIAESVD 250 260 270 280 290 300 GTIFSGLITL ALNGLANEYP DLKTAFYEEL SDFAVPEFKA GAENCLAENI FHYPLHQYFT 310 320 330 340 350 360 GPKRAFEKGW GLLKEDIFNK SIQDNLLIGL NKTYLPQVPV LIYHGTVDEI IPIKDPHAQY 370 380 390 400 410 420 QLWCDWGIES LEFAEDLSTG HLAETFTGAP AALAWIDARF DGKTPIQGCS HTTRLTNLLY 430 440 450 460 PNTSDSTHSY FLGIYQAVFG TPLGPGINGD NITINSGLLG LVSSII

References

[1]

"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: 1161.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF189152 Genomic DNA. Translation: AAF34253.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.1.3. 1124.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP2_CANAL

Accession

Primary (citable) accession number: Q9P8W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)