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Q9P8W5 (LIP2_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipase 2
EC=3.1.1.3
Gene names
Name:LIP2
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted Ref.1.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontriglyceride lipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 466450Lipase 2
PRO_0000017821

Sites

Active site1961Charge relay system By similarity
Active site3441Charge relay system By similarity

Amino acid modifications

Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation3191N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9P8W5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C4F4C994B761F42C

FASTA46650,422
        10         20         30         40         50         60 
MKGLVFLLGL LPTIYASLVH ITPASEDDFY NPPAGFESAK NGDILKLRNS PNRLASFYFP 

        70         80         90        100        110        120 
IDVKNAWQLL VKSEDSFGNP NAFVTTLIEP YNADPSKVVS YQTWEDASNI NCSPSYGAQF 

       130        140        150        160        170        180 
GSPLSTITTQ IDMTLIVPPL RSGYYVVTPD YEGPKATFAV GRQSGQATLD SVRAILKSGS 

       190        200        210        220        230        240 
FSGINEDAKV ALWGYSGGSL ATGWAAALQP VYAPELQKNI VGAAVGGFAA NITAIAESVD 

       250        260        270        280        290        300 
GTIFSGLITL ALNGLANEYP DLKTAFYEEL SDFAVPEFKA GAENCLAENI FHYPLHQYFT 

       310        320        330        340        350        360 
GPKRAFEKGW GLLKEDIFNK SIQDNLLIGL NKTYLPQVPV LIYHGTVDEI IPIKDPHAQY 

       370        380        390        400        410        420 
QLWCDWGIES LEFAEDLSTG HLAETFTGAP AALAWIDARF DGKTPIQGCS HTTRLTNLLY 

       430        440        450        460 
PNTSDSTHSY FLGIYQAVFG TPLGPGINGD NITINSGLLG LVSSII

« Hide

References

[1]"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members."
Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.
Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
Strain: 1161.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF189152 Genomic DNA. Translation: AAF34253.1.

3D structure databases

ProteinModelPortalQ9P8W5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005152. Lipase_secreted.
[Graphical view]
PfamPF03583. LIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIP2_CANAX
AccessionPrimary (citable) accession number: Q9P8W5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2000
Last modified: October 19, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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