Reviewed, UniProtKB/Swiss-Prot Q9P8W2 (LIP3_CANAL)

Names and origin

Protein names

Recommended name:
    Lipase 3
    EC=3.1.1.3

Gene names

Name:

LIP3

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted. Ref.1
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 471	455	Lipase 3		PRO_0000017822
Sites
	Active site	196	1	Charge relay system By similarity
	Active site	344	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	319	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential
	Glycosylation	422	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P8W2-1 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: 15AC64A3B11BD868	FASTA	471	51,226
	10 20 30 40 50 60 MKTLVVLCTL LSIIFASPLS LKSPLVDDFY NPPRGYESAK LGEILKLRKT PGKISSLFIP 70 80 90 100 110 120 VEVKNSWQLL VRSEDSFGNA AAIVTTVIEP FNADPSKVVS YQSWEDAANI ECSPSYGMQF 130 140 150 160 170 180 GAPLSSVQTQ VDMIFIVPLL DKGCFVVLPD YEGPKSTFGV GRQSGKATLD SIKAVLKTKD 190 200 210 220 230 240 FSGINDDAQV AMWGYSGGTI AAGWAATLQP KYAQELKKNL IGAALGGFVI NITATAEATD 250 260 270 280 290 300 GTLFAGLIPN ALNGLANEFP DFKKRMYEVV EKRYEGALQQ GTQHCLGGAI LHFAFDQVFT 310 320 330 340 350 360 GDHRYFEQGY GLLEEEVFNR TISGNSLLYM DQEYLPDIPI FVYHGSLDGI VPIPDVHGVY 370 380 390 400 410 420 KNWCDWGIDS FEFAEDSLNG HLTEIVVGAP AAITWLDARF DGQPVVEGCK KTTRITNFSY 430 440 450 460 470 PNISDSTRNF FKGILDSLTA SQLGPGVTSD NVTLSGLTGF MGGLSKFKKS V

References

[1]

"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: 1161.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF191316 Genomic DNA. Translation: AAF69520.2.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.1.3. 1124.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP3_CANAL

Accession

Primary (citable) accession number: Q9P8W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)