Reviewed, UniProtKB/Swiss-Prot Q9P8W1 (LIP4_CANAL)

Names and origin

Protein names

Recommended name:
    Lipase 4
    EC=3.1.1.3

Gene names

Name:	LIP4
ORF Names:	CaO19.2133

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 14	14	Potential
	Chain	15 – 459	445	Lipase 4		PRO_0000017823
Sites
	Active site	194	1	Charge relay system By similarity
	Active site	339	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	266	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P8W1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: DCB08D9C132C3658	FASTA	459	49,555
	10 20 30 40 50 60 MLFLLFLLVA PIYAGLILPT KPSNDPFYNA PAGFEKAAVG DILQSRKTPK PITGVFVPVK 70 80 90 100 110 120 IQNSWQLLVR SEDSFGNPNV IVTTVMEPFN ADPSKLASYQ VFEDSAKADC APSYALQFGS 130 140 150 160 170 180 DVTTIATQVE TYLLAPLLDQ GYYVVSPDYE GPKSTFTVGK QSGQAVLNSI RAALKSGKIT 190 200 210 220 230 240 NLAENAKVVM WGYSGGSLAS GWAAALQPNY APELGGNLLG AALGGFVTNI TATAEATDGT 250 260 270 280 290 300 VFAGIMANAL GGVANEYPEF KQILQNDTDK QSVFDQFDNH CLADGVINYI GKHFLSGTNK 310 320 330 340 350 360 IFKSGWNILK NPTISKIVED NGLVYQKQLV PKIPILIYHG AIDQIVPIVN VKKTYQNWCD 370 380 390 400 410 420 AGIASLEFSE DATNGHITET IVGAPVALTW IINRFNGKQT VSGCQHVKRT SNFEYPNIPP 430 440 450 SILNYFKAAL NILIQKGLGP DIQKDQVNPD GLKKISILV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: 1161.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191317 Genomic DNA. Translation: AAF69521.1. AACQ01000158 Genomic DNA. Translation: EAK93222.1.
RefSeq	XP_712408.1.
3D structure databases
SMR	Q9P8W1. Positions 18-440.
ModBase	Search...
Genome annotation databases
GeneID	3645987.
KEGG	cal:CaO19.2133.
Organism-specific databases
CGD	CAL0005323. LIP4.
Phylogenomic databases
OrthoDB	EOG90VX5V.
Enzyme and pathway databases
BRENDA	3.1.1.3. 1124.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP4_CANAL

Accession

Primary (citable) accession number: Q9P8W1
Secondary accession number(s): Q59RY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)