Reviewed, UniProtKB/Swiss-Prot Q9P8W0 (LIP5_CANAL)

Names and origin

Protein names

Recommended name:
    Lipase 5
    EC=3.1.1.3

Gene names

Name:

LIP5

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 14	14	Potential
	Chain	15 – 463	449	Lipase 5		PRO_0000017824
Sites
	Active site	194	1	Charge relay system By similarity
	Active site	339	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	229	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P8W0-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 448390544556CDD4	FASTA	463	49,977
	10 20 30 40 50 60 MLYLILFLIA PIYAGLIFPT KPSSDPFYNP PKGFENAAVG DILQSRATPK SITGGFTPLK 70 80 90 100 110 120 IQNSWQLLVR SEDSFGNPNV IVTTVIEPVN ADPSKIASYQ VFEDAAKADC APSYALQFGS 130 140 150 160 170 180 DLTTFVTQAE MYLMAPLLDQ GYYVVSPDYE GPKSTFTIGK QSGQAVLNSI RAALKSGKIT 190 200 210 220 230 240 NIKDDAKVVM WGYSGGSLAS GWAAALQPSY APELGGNLLG AALGGFVTNI TATAQATDGT 250 260 270 280 290 300 VFAGIVANAL GGVANEYPEF KSILQSDTDK KSVFEEFDGH CLIDGVLNYI GTSFLTGDHK 310 320 330 340 350 360 IFKTGWDILK NPKIGKVVED NGLVYQKQLV PKIPVFIYHG SIDQIVPIVD TKKTYQNWCD 370 380 390 400 410 420 AGISSLEFAE DASNGHLTEA IMGAPAALTW IIDRFDGKQT VSGCQHIQRF SNLEYPNIPS 430 440 450 460 SIANYFKAAM DVVLHLGLGP DVQKDQVSPE GIKKLGSIEM RWL

References

[1]

"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: SC5314.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191318 Genomic DNA. Translation: AAF69522.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.1.3. 1124.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP5_CANAL

Accession

Primary (citable) accession number: Q9P8W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)