Q9P8V9 (LIP8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 8
EC=3.1.1.3

Gene names

Name:	LIP8
ORF Names:	CaO19.8925

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 14	14	Potential
	Chain	15 – 460	446	Lipase 8		PRO_0000017827
Sites
	Active site	194	1	Charge relay system By similarity
	Active site	339	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P8V9 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: DB0DFEFE4A5BD9B4	FASTA	460	49,896
	10 20 30 40 50 60 MLFLLFLLIT PIYAGLIFPT KPSSDPFYNP PKGFEKAAVG DILQSRETPK SITGRFAPLK 70 80 90 100 110 120 IQNSWQLLVR SEDSFGNPNA IVTTVIEPVN ADPSKIASYQ VFEDAAKADC APSYALQFGS 130 140 150 160 170 180 DLTTFVTQAE MYLMAPLLDQ GYYVVSPDYE GPKSTFTIGK QSGQAVLNSI RATLKSSKIT 190 200 210 220 230 240 NIKEDAKVVM WGYSGGSLAS GWAAALQPSY APELSSSLLG AALGGFVTNI TATAQAADGT 250 260 270 280 290 300 VFAGIVANAL GGVANEYPEF KSILQSDTDK KSVFDEFDSH CLADGVIDYI NTSFLTGDNK 310 320 330 340 350 360 IFKTGWDILK SPTIAKIVED NGLVYQKQLV PKIPIFVYHG SIDQIVPIVN VKKTYQNWCE 370 380 390 400 410 420 GGISSLEFAE DGTNGHLTET VVGAPAALTW IIDRFNGKQT VSGCQHDKRL SNFQYPNISS 430 440 450 460 SILKYFKVAL DTMMSNGLGS DIQKDKITPD DLRKFLLGGW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191321 Genomic DNA. Translation: AAF69523.2. AACQ01000188 Genomic DNA. Translation: EAK92445.1.
RefSeq	XP_711667.1. XM_706575.1.
3D structure databases
ProteinModelPortal	Q9P8V9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646731.
KEGG	cal:CaO19.8925.
Organism-specific databases
CGD	CAL0072546. LIP8.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP8_CANAL

Accession

Primary (citable) accession number: Q9P8V9
Secondary accession number(s): Q59PM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program