Reviewed, UniProtKB/Swiss-Prot Q9P8R5 (XYL1_ASPNG)

Names and origin

Protein names

Recommended name:
    NAD(P)H-dependent D-xylose reductase
      Short name=XR
    EC=1.1.1.-

Gene names

Name:

xyrA

Organism

Aspergillus niger

Taxonomic identifier

5061 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reduces D-xylose into xylitol.
Pathway	Carbohydrate metabolism; D-xylose degradation.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	NAD(P)H-dependent D-xylose reductase		PRO_0000124658
Regions
	Nucleotide binding	215 – 281	67	NAD or NADP By similarity
Sites
	Active site	50	1	Proton donor By similarity
	Binding site	112	1	Substrate By similarity
	Site	79	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9P8R5-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C7D6DB56D37E973F	FASTA	319	36,095
	10 20 30 40 50 60 MASPTVKLNS GYDMPLVGFG LWKVNNDTCA DQIYHAIKEG YRLFDGACDY GNEVEAGQGI 70 80 90 100 110 120 ARAIKDGLVK REELFIVSKL WNSFHDGDRV EPICRKQLAD WGIDYFDLYI VHFPISLKYV 130 140 150 160 170 180 DPAVRYPPGW KSEKDELEFG NATIQETWTA MESLVDKKLA RSIGISNFSA QLVMDLLRYA 190 200 210 220 230 240 RIRPATLQIE HHPYLTQTRL VEYAQKEGLT VTAYSSFGPL SFLELSVQNA VDSPPLFEHQ 250 260 270 280 290 300 LVKSIAEKHG RTPAQVLLRW ATQRGIAVIP KSNNPQRLKQ NLDVTGWNLE EEEIKAISGL 310 DRGLRFNDPL GYGLYAPIF

References

[1]

"The Aspergillus niger transcriptional activator XlnR, which is involved in the degradation of the polysaccharides xylan and cellulose, also regulates D-xylose reductase gene expression." Hasper A.A., Visser J., de Graaff L.H. Mol. Microbiol. 36:193-200(2000) [PubMed: 10760176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF219625 Genomic DNA. Translation: AAF61912.1.
3D structure databases
HSSP	HSSP built from PDB template 1JEZ based on UniProtKB O74237.
ModBase	Search...
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
ProDom	PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYL1_ASPNG

Accession

Primary (citable) accession number: Q9P8R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)