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Q9P8Q7 (ACEA_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Isocitrate lyase
PRO_0000068784

Regions

Motif548 – 5503Microbody targeting signal Potential

Sites

Active site2101 Probable

Sequences

Sequence LengthMass (Da)Tools
Q9P8Q7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FFBDB59FB60BE337

FASTA55061,395
        10         20         30         40         50         60 
MPYTPIDIQK EEADFQKEVA EIKKWWSEPR WRKTKRIYSA EDIAKKRGTL KINHPSSQQA 

        70         80         90        100        110        120 
DKLFKLLETH DADKTVSFTF GALDPIHVAQ MAKYLDSIYV SGWQCSSTAS TSNEPSPDLA 

       130        140        150        160        170        180 
DYPMDTVPNK VEHLWFAQLF HDRKQREERL TLSKEERAKT PYIDFLRPII ADADTGHGGI 

       190        200        210        220        230        240 
TAIIKLTKMF IERGAAGIHI EDQAPGTKKC GHMAGKVLVP VQEHINRLVA IRASADIFGS 

       250        260        270        280        290        300 
NLLAVARTDS EAATLITSTI DHRDHYFIIG ATNPEAGDLA ALMAEAESKG IYGNELAAIE 

       310        320        330        340        350        360 
SEWTKKAGLK LFHEAVIDEI KNGNYSNKDA LIKKFTDKVN PLSHTSHKEA KKLAKELTGK 

       370        380        390        400        410        420 
DIYFNWDVAR AREGYYRYQG GTQCAVMRGR AFAPYADLIW MESALPDYAQ AKEFADGVKA 

       430        440        450        460        470        480 
AVPDQWLAYN LSPSFNWNKA MPADEQETYI KRLGKLGYVW QFITLAGLHT TALAVDDFSN 

       490        500        510        520        530        540 
QYSQIGMKAY GQTVQQPEIE KGVEVVKHQK WSGATYIDGL LKMVSGGVTS TAAMGQGVTE 

       550 
DQFKESKAKA

« Hide

References

[1]"Gluconeogenesis in Candida albicans."
Eschrich D., Koetter P., Entian K.-D.
FEMS Yeast Res. 2:315-325(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF222905 Genomic DNA. Translation: AAF34690.1.

3D structure databases

ProteinModelPortalQ9P8Q7.
SMRQ9P8Q7. Positions 8-527.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2224.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBQ9P8Q7.
ChEMBLCHEMBL5359.

Entry information

Entry nameACEA_CANAX
AccessionPrimary (citable) accession number: Q9P8Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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