SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9P8P4

- PLB2_ASPFU

UniProt

Q9P8P4 - PLB2_ASPFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysophospholipase 2

Gene
plb2, AFUA_5G01340
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.5. 508.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 2
Gene namesi
Name:plb2
ORF Names:AFUA_5G01340
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Lysophospholipase 2PRO_0000245557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi501 – 5011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi529 – 5291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi553 – 5531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi570 – 5701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 574544PLA2cAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Phylogenomic databases

eggNOGiNOG276264.
HOGENOMiHOG000189547.
KOiK13333.
OMAiANITFLH.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P8P4-1 [UniParc]FASTAAdd to Basket

« Hide

MYKNRVELTT TAPVNRALPN APDGYTPQGE TCPSKRPSIR NATALSSAET    50
SWLKARRNNT KDALKAFLSR VDLGSFNGSD YIANHSANAS ALPNIGIAVS 100
GGGYRALMNG GGALQAFDNR TTNSTHSGQL GGILQSATYL SGLSGGSWLV 150
GSIYMNNFSD VSSLQDNGSV WQFQDSIFSG PTQSTTWDIG TVEYYSQLLG 200
AVDGKSNAGY EVSITDYWGR SLSYQLINAS EGGVGYTWSS IALSKDFQAG 250
TMPMPLVIAD GRAPGEILVP ANTTVFEFNP WEFGSWDKSL SAFVSLEFLG 300
SNFSKGTLAT GEKCVRGFDN AGFIMGTSSS LFNQAFLQMN NTDAPSVVKD 350
AISAILGKIG SENNDIAVYK PNPFYRYASQ SKYTSSPSLT LVDGGEDLQN 400
IPLDPLLQPQ RHVDVILAVD SSADTTTRWP NGTSLVATYE RNVDSSQRNS 450
SLPFPSVPDQ NTFVNLGLNN RPTFFGCNSS NATGAPLVVY IPNAPYIYPS 500
NVSTFDLQYN TSERNAIIEN GYDVATLGNG TVDSNWPACL ACAILSRSFE 550
RTNTTVPKTC STCFKTYCWN GTINATTPGD YYPTLKLH 588
Length:588
Mass (Da):63,239
Last modified:July 11, 2006 - v2
Checksum:iD268F56BC6EABDD5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981L → N in strain: ATCC 90240 / AF-10. 1 Publication
Natural varianti573 – 5731I → V in strain: ATCC 90240 / AF-10. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL86170.1.
AF223005 Genomic DNA. Translation: AAF64039.1.
RefSeqiXP_748208.1. XM_743115.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002626; CADAFUAP00002626; CADAFUAG00002626.
GeneIDi3505495.
KEGGiafm:AFUA_5G01340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL86170.1 .
AF223005 Genomic DNA. Translation: AAF64039.1 .
RefSeqi XP_748208.1. XM_743115.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00002626 ; CADAFUAP00002626 ; CADAFUAG00002626 .
GeneIDi 3505495.
KEGGi afm:AFUA_5G01340.

Phylogenomic databases

eggNOGi NOG276264.
HOGENOMi HOG000189547.
KOi K13333.
OMAi ANITFLH.
OrthoDBi EOG7N37NC.

Enzyme and pathway databases

BRENDAi 3.1.1.5. 508.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
  2. "Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus."
    Shen D.-K., Noodeh A.D., Kazemi A., Grillot R., Robson G.D., Brugere J.-F.
    FEMS Microbiol. Lett. 239:87-93(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 393-573, VARIANTS ASN-398 AND VAL-573.
    Strain: ATCC 90240 / AF-10.

Entry informationi

Entry nameiPLB2_ASPFU
AccessioniPrimary (citable) accession number: Q9P8P4
Secondary accession number(s): Q4WE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi