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Protein

Lysophospholipase 2

Gene

plb2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.5. 508.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 2
Gene namesi
Name:plb2
ORF Names:AFUA_5G01340
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Lysophospholipase 2PRO_0000245557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 574544PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276264.
HOGENOMiHOG000189547.
InParanoidiQ9P8P4.
KOiK13333.
OMAiDKTIAYY.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P8P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKNRVELTT TAPVNRALPN APDGYTPQGE TCPSKRPSIR NATALSSAET
60 70 80 90 100
SWLKARRNNT KDALKAFLSR VDLGSFNGSD YIANHSANAS ALPNIGIAVS
110 120 130 140 150
GGGYRALMNG GGALQAFDNR TTNSTHSGQL GGILQSATYL SGLSGGSWLV
160 170 180 190 200
GSIYMNNFSD VSSLQDNGSV WQFQDSIFSG PTQSTTWDIG TVEYYSQLLG
210 220 230 240 250
AVDGKSNAGY EVSITDYWGR SLSYQLINAS EGGVGYTWSS IALSKDFQAG
260 270 280 290 300
TMPMPLVIAD GRAPGEILVP ANTTVFEFNP WEFGSWDKSL SAFVSLEFLG
310 320 330 340 350
SNFSKGTLAT GEKCVRGFDN AGFIMGTSSS LFNQAFLQMN NTDAPSVVKD
360 370 380 390 400
AISAILGKIG SENNDIAVYK PNPFYRYASQ SKYTSSPSLT LVDGGEDLQN
410 420 430 440 450
IPLDPLLQPQ RHVDVILAVD SSADTTTRWP NGTSLVATYE RNVDSSQRNS
460 470 480 490 500
SLPFPSVPDQ NTFVNLGLNN RPTFFGCNSS NATGAPLVVY IPNAPYIYPS
510 520 530 540 550
NVSTFDLQYN TSERNAIIEN GYDVATLGNG TVDSNWPACL ACAILSRSFE
560 570 580
RTNTTVPKTC STCFKTYCWN GTINATTPGD YYPTLKLH
Length:588
Mass (Da):63,239
Last modified:July 11, 2006 - v2
Checksum:iD268F56BC6EABDD5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981L → N in strain: ATCC 90240 / AF-10. 1 Publication
Natural varianti573 – 5731I → V in strain: ATCC 90240 / AF-10. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL86170.1.
AF223005 Genomic DNA. Translation: AAF64039.1.
RefSeqiXP_748208.1. XM_743115.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002626; CADAFUAP00002626; CADAFUAG00002626.
GeneIDi3505495.
KEGGiafm:AFUA_5G01340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL86170.1.
AF223005 Genomic DNA. Translation: AAF64039.1.
RefSeqiXP_748208.1. XM_743115.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00002626; CADAFUAP00002626; CADAFUAG00002626.
GeneIDi3505495.
KEGGiafm:AFUA_5G01340.

Phylogenomic databases

eggNOGiNOG276264.
HOGENOMiHOG000189547.
InParanoidiQ9P8P4.
KOiK13333.
OMAiDKTIAYY.
OrthoDBiEOG7N37NC.

Enzyme and pathway databases

BRENDAi3.1.1.5. 508.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
  2. "Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus."
    Shen D.-K., Noodeh A.D., Kazemi A., Grillot R., Robson G.D., Brugere J.-F.
    FEMS Microbiol. Lett. 239:87-93(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 393-573, VARIANTS ASN-398 AND VAL-573.
    Strain: ATCC 90240 / AF-10.

Entry informationi

Entry nameiPLB2_ASPFU
AccessioniPrimary (citable) accession number: Q9P8P4
Secondary accession number(s): Q4WE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: January 7, 2015
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.