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Protein

Lysophospholipase 2

Gene

plb2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.5. 508.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 2
Gene namesi
Name:plb2
ORF Names:AFUA_5G01340
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g01340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455571 – 588Lysophospholipase 2Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 574PLA2cPROSITE-ProRule annotationAdd BLAST544

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiQ9P8P4.
KOiK13333.
OMAiGMAFPYV.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P8P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKNRVELTT TAPVNRALPN APDGYTPQGE TCPSKRPSIR NATALSSAET
60 70 80 90 100
SWLKARRNNT KDALKAFLSR VDLGSFNGSD YIANHSANAS ALPNIGIAVS
110 120 130 140 150
GGGYRALMNG GGALQAFDNR TTNSTHSGQL GGILQSATYL SGLSGGSWLV
160 170 180 190 200
GSIYMNNFSD VSSLQDNGSV WQFQDSIFSG PTQSTTWDIG TVEYYSQLLG
210 220 230 240 250
AVDGKSNAGY EVSITDYWGR SLSYQLINAS EGGVGYTWSS IALSKDFQAG
260 270 280 290 300
TMPMPLVIAD GRAPGEILVP ANTTVFEFNP WEFGSWDKSL SAFVSLEFLG
310 320 330 340 350
SNFSKGTLAT GEKCVRGFDN AGFIMGTSSS LFNQAFLQMN NTDAPSVVKD
360 370 380 390 400
AISAILGKIG SENNDIAVYK PNPFYRYASQ SKYTSSPSLT LVDGGEDLQN
410 420 430 440 450
IPLDPLLQPQ RHVDVILAVD SSADTTTRWP NGTSLVATYE RNVDSSQRNS
460 470 480 490 500
SLPFPSVPDQ NTFVNLGLNN RPTFFGCNSS NATGAPLVVY IPNAPYIYPS
510 520 530 540 550
NVSTFDLQYN TSERNAIIEN GYDVATLGNG TVDSNWPACL ACAILSRSFE
560 570 580
RTNTTVPKTC STCFKTYCWN GTINATTPGD YYPTLKLH
Length:588
Mass (Da):63,239
Last modified:July 11, 2006 - v2
Checksum:iD268F56BC6EABDD5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti398L → N in strain: ATCC 90240 / AF-10. 1 Publication1
Natural varianti573I → V in strain: ATCC 90240 / AF-10. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL86170.1.
AF223005 Genomic DNA. Translation: AAF64039.1.
RefSeqiXP_748208.1. XM_743115.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002626; CADAFUAP00002626; CADAFUAG00002626.
GeneIDi3505495.
KEGGiafm:AFUA_5G01340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL86170.1.
AF223005 Genomic DNA. Translation: AAF64039.1.
RefSeqiXP_748208.1. XM_743115.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00002626; CADAFUAP00002626; CADAFUAG00002626.
GeneIDi3505495.
KEGGiafm:AFUA_5G01340.

Organism-specific databases

EuPathDBiFungiDB:Afu5g01340.

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiQ9P8P4.
KOiK13333.
OMAiGMAFPYV.
OrthoDBiEOG092C2IZ9.

Enzyme and pathway databases

BRENDAi3.1.1.5. 508.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLB2_ASPFU
AccessioniPrimary (citable) accession number: Q9P8P4
Secondary accession number(s): Q4WE07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: May 10, 2017
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.