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Q9P8P4 (PLB2_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 2

EC=3.1.1.5
Alternative name(s):
Phospholipase B 2
Gene names
Name:plb2
ORF Names:AFUA_5G01340
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Lysophospholipase 2
PRO_0000245557

Regions

Domain31 – 574544PLA2c

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation4811N-linked (GlcNAc...) Potential
Glycosylation5011N-linked (GlcNAc...) Potential
Glycosylation5101N-linked (GlcNAc...) Potential
Glycosylation5291N-linked (GlcNAc...) Potential
Glycosylation5531N-linked (GlcNAc...) Potential
Glycosylation5701N-linked (GlcNAc...) Potential
Glycosylation5741N-linked (GlcNAc...) Potential

Natural variations

Natural variant3981L → N in strain: ATCC 90240 / AF-10. Ref.2
Natural variant5731I → V in strain: ATCC 90240 / AF-10. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9P8P4 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: D268F56BC6EABDD5

FASTA58863,239
        10         20         30         40         50         60 
MYKNRVELTT TAPVNRALPN APDGYTPQGE TCPSKRPSIR NATALSSAET SWLKARRNNT 

        70         80         90        100        110        120 
KDALKAFLSR VDLGSFNGSD YIANHSANAS ALPNIGIAVS GGGYRALMNG GGALQAFDNR 

       130        140        150        160        170        180 
TTNSTHSGQL GGILQSATYL SGLSGGSWLV GSIYMNNFSD VSSLQDNGSV WQFQDSIFSG 

       190        200        210        220        230        240 
PTQSTTWDIG TVEYYSQLLG AVDGKSNAGY EVSITDYWGR SLSYQLINAS EGGVGYTWSS 

       250        260        270        280        290        300 
IALSKDFQAG TMPMPLVIAD GRAPGEILVP ANTTVFEFNP WEFGSWDKSL SAFVSLEFLG 

       310        320        330        340        350        360 
SNFSKGTLAT GEKCVRGFDN AGFIMGTSSS LFNQAFLQMN NTDAPSVVKD AISAILGKIG 

       370        380        390        400        410        420 
SENNDIAVYK PNPFYRYASQ SKYTSSPSLT LVDGGEDLQN IPLDPLLQPQ RHVDVILAVD 

       430        440        450        460        470        480 
SSADTTTRWP NGTSLVATYE RNVDSSQRNS SLPFPSVPDQ NTFVNLGLNN RPTFFGCNSS 

       490        500        510        520        530        540 
NATGAPLVVY IPNAPYIYPS NVSTFDLQYN TSERNAIIEN GYDVATLGNG TVDSNWPACL 

       550        560        570        580 
ACAILSRSFE RTNTTVPKTC STCFKTYCWN GTINATTPGD YYPTLKLH 

« Hide

References

« Hide 'large scale' references
[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
[2]"Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus."
Shen D.-K., Noodeh A.D., Kazemi A., Grillot R., Robson G.D., Brugere J.-F.
FEMS Microbiol. Lett. 239:87-93(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 393-573, VARIANTS ASN-398 AND VAL-573.
Strain: ATCC 90240 / AF-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000011 Genomic DNA. Translation: EAL86170.1.
AF223005 Genomic DNA. Translation: AAF64039.1.
RefSeqXP_748208.1. XM_743115.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00002626; CADAFUAP00002626; CADAFUAG00002626.
GeneID3505495.
KEGGafm:AFUA_5G01340.

Phylogenomic databases

eggNOGNOG276264.
HOGENOMHOG000189547.
KOK13333.
OMADANSTIF.
OrthoDBEOG7N37NC.

Enzyme and pathway databases

BRENDA3.1.1.5. 508.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB2_ASPFU
AccessionPrimary (citable) accession number: Q9P8P4
Secondary accession number(s): Q4WE07
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 13, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families