Q9P8P2J9VV08PLB1_CRYNHPhospholipase B3.1.1.5LysophospholipasePLB1CNAG_06085Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)Filobasidiella neoformans var. grubiiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complexExtracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.NUCLEOTIDE SEQUENCE [GENOMIC DNA]Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans.FUNCTIONCATALYTIC ACTIVITYACTIVITY REGULATIONBIOPHYSICOCHEMICAL PROPERTIESSUBCELLULAR LOCATIONGLYCOSYLATIONLipid rafts in Cryptococcus neoformans concentrate the virulence determinants phospholipase B1 and Cu/Zn superoxide dismutase.FUNCTIONCATALYTIC ACTIVITYSUBCELLULAR LOCATIONExhibits phospholipase B (PLB), lysophospholipase (LPL) and lysophospholipase/transacylase (LPTA) activities.a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholineInhibited by Fe(3+) ion.Active only at acidic pHs.SecretedCell membranePeripheral membrane proteinLocalizes to lipid rafts in the cell membrane prior to secretion.N-glycosylated.Belongs to the lysophospholipase family.PubMed:10749672 describes peptide sequences that do not match PLB1, but originate from a copurified, contaminating chitin deacetylase.Cell membraneGlycoproteinHydrolaseLipid degradationLipid metabolismMembraneSecretedSignalAGKNMSIATATFAFSLFATIAFAVPPETPRIELQAERGLGDKSYAPWQVDCPSNVTWIRNATTGLGSGERAYIEAREKLVQPVIEQMMAARGLETPPRTPNIGVALSGGGYRAMLTGLGGIMGMMNESTEASESETGGWLDGVSYWAGLSGGSWATGTFMSNGGQLPTNLLENLWNIDSNLVFPDDDKLSFYTELYTETNAKSDLGFPIQITDVWGLAIGSHVLPERYQLSNTPNLTFSSLPSVVSALGNASLPMPIIIAADRKRREAGELVIAENATVWEFTPYEFGSWAFGSQYKSPGAFTPIEYLGTSVDDGSPNGTCWKGFDQLSFVMGTSATLFNGAFLELNGTDSGLLTNLITAFLADLGEDQADISRIPNTFSNYNSGENPIYNLTYITLVDAGETNQNIPLEPLLVPTRDVDAIVAFDSSYDTDYIWPNGTALRTTYERAKVLAEHENTRVLMPEVPSMNGFVNGGYNSRPTFFGCNDTTTPLIIYVPSYPWSFAANTSTYQLSYENDEANEMLLNGMRSLTLNHSVPTWPTCFACALTDRSFMYTSENRSTTCQKCFDTWCWAGDDNTTEPATYEPVINSVPPWLVANNLSIGVADAPASNESTAGTASSGAAKADVSMGMVALAAGLGLML
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