Reviewed,
UniProtKB/Swiss-Prot Q9P885 (GGPPS_RHIRA)
Last modified
June 16, 2009.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Geranylgeranyl pyrophosphate synthetase Short name=GGPP synthetase Short name=GGPPSase Alternative name(s): Geranylgeranyl diphosphate synthase Including the following 3 domains: 1- Recommended name: Dimethylallyltranstransferase EC=2.5.1.1 2- Recommended name: Geranyltranstransferase EC=2.5.1.10 3- Recommended name: Farnesyltranstransferase EC=2.5.1.29 | ||
| Gene names |
| ||
| Organism | Rhizomucor racemosus (Mucor circinelloides f. lusitanicus) | ||
| Taxonomic identifier | 4841 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Mucor |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Ref.1 Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Ref.1 Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. Ref.1 |
| Pathway | Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Ref.1 Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Ref.1 Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1. Ref.1 |
| Subcellular location | |
| Induction | By blue light. Ref.1 |
| Sequence similarities | Belongs to the FPP/GGPP synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carotenoid biosynthesis Isoprene biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
| Technical term | Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | carotenoid biosynthetic process Ref.1 Inferred from direct assay. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fractionInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Ref.1Inferred from direct assay. Source: UniProtKB geranyltranstransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | Geranylgeranyl pyrophosphate synthetase | PRO_0000123967 | |||||
Sites | |||||||||
| Active site | 156 | 1 | By similarity UniProtKB Q92236 | ||||||
Sequences
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References
| [1] | "Expression of the carG gene, encoding geranylgeranyl pyrophosphate synthase, is up-regulated by blue light in Mucor circinelloides." Velayos A., Papp T., Aguilar-Elena R., Fuentes-Vicente M., Eslava A.P., Iturriaga E.A., Alvarez M.I. Curr. Genet. 43:112-120(2003) [PubMed: 12695851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, PATHWAY, INDUCTION. Strain: ATCC 1216b / CBS 277.49 / NRRL 3631. Tissue: Mycelium. |
Cross-references
Sequence databases | |
|---|---|
| AJ276129 Genomic DNA. Translation: CAB89115.1. | |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| PANTHER | PTHR12001. Polyprenyl_synt. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| PROSITE | PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GGPPS_RHIRA | ||||||||
| Accession | Primary (citable) accession number: Q9P885 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


