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Q9P885 (GGPPS_RHIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl pyrophosphate synthase
Short name=GGPP synthase
Short name=GGPPSase
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
EC=2.5.1.1
Farnesyl diphosphate synthase
Farnesyltranstransferase
EC=2.5.1.29
Geranylgeranyl diphosphate synthase
Geranyltranstransferase
EC=2.5.1.10
Gene names
Name:carG
OrganismRhizomucor racemosus (Mucor circinelloides f. lusitanicus)
Taxonomic identifier4841 [NCBI]
Taxonomic lineageEukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Mucor

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Ref.1

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. Ref.1

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. Ref.1

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Ref.1

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. Ref.1

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. Ref.1

Subcellular location

Cytoplasm.

Induction

By blue light. Ref.1

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Geranylgeranyl pyrophosphate synthase
PRO_0000123967

Sites

Metal binding691Magnesium 1 By similarity
Metal binding691Magnesium 2 By similarity
Metal binding731Magnesium 1 By similarity
Metal binding731Magnesium 2 By similarity
Metal binding1931Magnesium 3 By similarity
Binding site301Isopentenyl diphosphate By similarity
Binding site331Isopentenyl diphosphate By similarity
Binding site621Isopentenyl diphosphate By similarity
Binding site781Dimethylallyl diphosphate By similarity
Binding site791Isopentenyl diphosphate By similarity
Binding site1561Dimethylallyl diphosphate By similarity
Binding site1571Dimethylallyl diphosphate By similarity
Binding site1901Dimethylallyl diphosphate By similarity
Binding site2071Dimethylallyl diphosphate By similarity
Binding site2171Dimethylallyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9P885 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D440757CA7D0E215

FASTA30334,787
        10         20         30         40         50         60 
MLNSHNRTEE RSTEDIILEP YTYLISQPGK DIRAKLISAF DLWLHVPKDV LCVINKIIGM 

        70         80         90        100        110        120 
LHNASLMIDD VQDDSDLRRG VPVAHHIYGV PQTINTANYV IFLALQEVMK LNIPSMMQVC 

       130        140        150        160        170        180 
TEELINLHRG QGIELYWRDS LTCPTEEEYI DMVNNKTSGL LRLAVRLMQA ASESDIDYTP 

       190        200        210        220        230        240 
LVNIIGIHFQ VRDDYMNLQS TSYTNNKGFC EDLTEGKFSF PIIHAIRKDP SNRQLLNIIS 

       250        260        270        280        290        300 
QKPTSIEVKK YALEVIRKAG SFEYVREFLR QKEAESLKEI KRLGGNPLLE KYIETIRVEA 


TND

« Hide

References

[1]"Expression of the carG gene, encoding geranylgeranyl pyrophosphate synthase, is up-regulated by blue light in Mucor circinelloides."
Velayos A., Papp T., Aguilar-Elena R., Fuentes-Vicente M., Eslava A.P., Iturriaga E.A., Alvarez M.I.
Curr. Genet. 43:112-120(2003) [PubMed: 12695851] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, PATHWAY, INDUCTION.
Strain: ATCC 1216b / CBS 277.49 / NRRL 3631.
Tissue: Mycelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ276129 Genomic DNA. Translation: CAB89115.1.

3D structure databases

ProteinModelPortalQ9P885.
SMRQ9P885. Positions 12-295.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGPPS_RHIRA
AccessionPrimary (citable) accession number: Q9P885
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2000
Last modified: September 21, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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