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Protein

mRNA-decapping enzyme subunit 1

Gene

dcp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.1 Publication

GO - Molecular functioni

  • m7G(5')pppN diphosphatase activator activity Source: PomBase
  • mRNA binding Source: GO_Central

GO - Biological processi

  • deadenylation-dependent decapping of nuclear-transcribed mRNA Source: PomBase
  • deadenylation-independent decapping of nuclear-transcribed mRNA Source: PomBase
  • mRNA processing Source: UniProtKB-KW
  • nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' Source: PomBase
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, Nonsense-mediated mRNA decay

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme subunit 1
Gene namesi
Name:dcp1
ORF Names:SPBC3B9.21
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3B9.21.
PomBaseiSPBC3B9.21. dcp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: PomBase
  • cytoplasmic stress granule Source: PomBase
  • cytosol Source: PomBase
  • Dcp1-Dcp2 complex Source: PomBase
  • mRNA cap binding complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127mRNA-decapping enzyme subunit 1PRO_0000339336Add
BLAST

Proteomic databases

MaxQBiQ9P805.

Interactioni

Subunit structurei

Component of the decapping complex composed of dcp1 and dcp2.By similarity

Protein-protein interaction databases

BioGridi277548. 11 interactions.
DIPiDIP-29008N.
IntActiQ9P805. 2 interactions.
MINTiMINT-4706793.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1917Combined sources
Beta strandi23 – 3614Combined sources
Turni40 – 434Combined sources
Beta strandi47 – 5913Combined sources
Beta strandi64 – 7411Combined sources
Beta strandi77 – 815Combined sources
Helixi84 – 863Combined sources
Beta strandi87 – 904Combined sources
Beta strandi93 – 986Combined sources
Turni99 – 1013Combined sources
Beta strandi102 – 1109Combined sources
Helixi112 – 12413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QKLX-ray2.33A1-127[»]
2QKMX-ray2.80A/C/E/G1-127[»]
5J3QX-ray1.87A/C1-127[»]
5J3TX-ray1.60A1-127[»]
5J3YX-ray3.29A/C1-127[»]
5JP4X-ray2.04A1-127[»]
ProteinModelPortaliQ9P805.
SMRiQ9P805. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P805.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

InParanoidiQ9P805.
OMAiRESAQNT.
OrthoDBiEOG092C4RRH.
PhylomeDBiQ9P805.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. Dcp1.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 1 hit.
PfamiPF06058. DCP1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDENILRNA VNLQVLKFHY PEIESIIDIA SHVAVYQFDV GSQKWLKTSI
60 70 80 90 100
EGTFFLVKDQ RARVGYVILN RNSPENLYLF INHPSNVHLV DRYLIHRTEN
110 120
QHVVGLWMFD PNDMSRIFNI VKESLLR
Length:127
Mass (Da):14,983
Last modified:October 1, 2000 - v1
Checksum:iDD593F646C61EEC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB69661.1.
RefSeqiNP_596662.1. NM_001022584.2.

Genome annotation databases

EnsemblFungiiSPBC3B9.21.1; SPBC3B9.21.1:pep; SPBC3B9.21.
GeneIDi2541033.
KEGGispo:SPBC3B9.21.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB69661.1.
RefSeqiNP_596662.1. NM_001022584.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QKLX-ray2.33A1-127[»]
2QKMX-ray2.80A/C/E/G1-127[»]
5J3QX-ray1.87A/C1-127[»]
5J3TX-ray1.60A1-127[»]
5J3YX-ray3.29A/C1-127[»]
5JP4X-ray2.04A1-127[»]
ProteinModelPortaliQ9P805.
SMRiQ9P805. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277548. 11 interactions.
DIPiDIP-29008N.
IntActiQ9P805. 2 interactions.
MINTiMINT-4706793.

Proteomic databases

MaxQBiQ9P805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC3B9.21.1; SPBC3B9.21.1:pep; SPBC3B9.21.
GeneIDi2541033.
KEGGispo:SPBC3B9.21.

Organism-specific databases

EuPathDBiFungiDB:SPBC3B9.21.
PomBaseiSPBC3B9.21. dcp1.

Phylogenomic databases

InParanoidiQ9P805.
OMAiRESAQNT.
OrthoDBiEOG092C4RRH.
PhylomeDBiQ9P805.

Enzyme and pathway databases

ReactomeiR-SPO-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.

Miscellaneous databases

EvolutionaryTraceiQ9P805.
PROiQ9P805.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. Dcp1.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 1 hit.
PfamiPF06058. DCP1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCP1_SCHPO
AccessioniPrimary (citable) accession number: Q9P805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.