Q9P804 (TRM1_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 75.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: tRNA (guanine(26)-N(2))-dimethyltransferase EC=2.1.1.216 Alternative name(s): tRNA 2,2-dimethylguanosine-26 methyltransferase tRNA(guanine-26,N(2)-N(2)) methyltransferase tRNA(m(2,2)G26)dimethyltransferase | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||||
| Taxonomic identifier | 284812 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 548 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. |
| Catalytic activity | 2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA. |
| Subcellular location | Nucleus By similarity. Cytoplasm By similarity. Note: Nuclear/cytoplasmic compartments By similarity. |
| Sequence similarities | Belongs to the TRM1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | tRNA processing |
| Cellular component | Cytoplasm Nucleus |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | mitochondrion Inferred from direct assay. Source: GeneDB_Spombe nuclear membraneInferred from sequence or structural similarity. Source: GeneDB_Spombe |
| Molecular function | RNA binding Inferred from electronic annotation. Source: InterPro tRNA (guanine-N2-)-methyltransferase activityInferred from sequence or structural similarity. Source: GeneDB_Spombe |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The tRNA N2,N2-dimethylguanosine-26 methyltransferase encoded by gene trm1 increases efficiency of suppression of an ochre codon in Schizosaccharomyces pombe." Niederberger C., Graub R., Costa A., Desgres J., Schweingruber M.E. FEBS Lett. 464:67-70(1999) [PubMed: 10611485] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ224000 Genomic DNA. Translation: CAA11801.1. CU329671 Genomic DNA. Translation: CAA20101.2. |
| PIR | T39993. T46565. |
| RefSeq | NP_596547.1. NM_001022468.1. |
3D structure databases | |
| ProteinModelPortal | Q9P804. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9P804. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPBC25D12.05.1; SPBC25D12.05.1:pep; SPBC25D12.05. |
| GeneID | 2540604. |
| GenomeReviews | Gene locus trm1 in contig CU329671_GR. |
| KEGG | spo:SPBC25D12.05. |
| NMPDR | fig|4896.1.peg.2413. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC25D12.05. |
Phylogenomic databases | |
| eggNOG | fuNOG07744. |
| GeneTree | EFGT00050000005860. |
| HOGENOM | HBG386594. |
| OMA | LGGPMWA. |
| OrthoDB | EOG425925. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-004543-MONOMER. |
Gene expression databases | |
| ArrayExpress | Q9P804. |
Family and domain databases | |
| InterPro | IPR002905. TRM_MeTrfase. [Graphical view] |
| KO | K00555. |
| PANTHER | PTHR10631. TRM_mtfrase. 1 hit. |
| Pfam | PF02005. TRM. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00308. TRM1. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TRM1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q9P804 Secondary accession number(s): O74566 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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