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Protein

Probable DNA-directed RNA polymerase I subunit RPA2

Gene

rpa2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1089 – 111830C4-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-73762. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase I subunit RPA2 (EC:2.7.7.6)
Alternative name(s):
DNA-directed RNA polymerase I polypeptide 2
Short name:
RNA polymerase I subunit 2
Gene namesi
Name:rpa2
ORF Names:SPBP23A10.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP23A10.07.
PomBaseiSPBP23A10.07. rpa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11741174Probable DNA-directed RNA polymerase I subunit RPA2PRO_0000048079Add
BLAST

Proteomic databases

MaxQBiQ9P7X8.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits.By similarity

Protein-protein interaction databases

BioGridi277793. 9 interactions.
IntActiQ9P7X8. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1089 – 111830C4-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000222963.
InParanoidiQ9P7X8.
KOiK03002.
OMAiPGQLYLM.
OrthoDBiEOG092C06IY.
PhylomeDBiQ9P7X8.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
IPR009674. Rpa2_dom_4.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF06883. RNA_pol_Rpa2_4. 1 hit.
PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQTLERER TFKNPPKDGT SFPDLQKAVK PHVDSFNALT NAGLLNYAVK
60 70 80 90 100
EIGEKCAFDS ITQEEGGALK FGNKISFRVD EVQIAKPMLS SRERSSINRK
110 120 130 140 150
VYPAEARERL TTYKSRLVLK FSWSVNGGPR QSEMREVGMI PIMVRSNRCH
160 170 180 190 200
LEGLSPAELI AHKEESEEMG GYFIVNGIEK LIRMLILPKR NHPTAIIRPS
210 220 230 240 250
FANRGTSYSQ YGLSIRCVRP DQSSLTNTLH YLNNGVTMFR FHWRKNEYLI
260 270 280 290 300
PSMMILKALL ETSDKEIFEG IVGKDLGNTF LTDRVELMLR AYKSYGLYSQ
310 320 330 340 350
TETLQYLGSK FRVVLGVAED LTDVEVGRFL LQKVVLVHLR EAKDKFRLLL
360 370 380 390 400
FMIRKLYALV AGECCADNPD SPQHQEILLG GFLYGQILKE KIEDWLNSIR
410 420 430 440 450
AQINLDVRRS APGVDFSDRK YLTRVFSKIN NDIGTKLQYF LSTGNLVSNT
460 470 480 490 500
GLDLQQATGY TVVAEKLNFY RFLSHFRMVH RGAFFAELKT TTVRKLLPEA
510 520 530 540 550
WGFMCPVHTP DGSPCGLLNH LARKCEIVTH PSDVSQIPSL LLSLGVDPPS
560 570 580 590 600
VVGHESGWGC VQLDGKIVGW CTYKLAKHVA DVLRLMKIEY AVKLRNGTAT
610 620 630 640 650
EPAKVPLDLE IGYVPPSHNG QYPGLYLFSN PARMVRPVKH ISTGELDMLG
660 670 680 690 700
PFEQVYMDIA CFPKEIVPKV STHVEYSPTN VLSIVANMTP FSDFNQSPRN
710 720 730 740 750
MYQCQMGKQT MGTPGTALRY RTDNKLYRLQ TGQTPVVRPK LHNTYGLDHY
760 770 780 790 800
PNGTNAVVAV ISYTGYDMED AMILNKSAHE RGFGYGTVYK GESFDLSQKR
810 820 830 840 850
RRGEPVVHHF GFAPGSTPRR EWLQKLDADG LPFIGIKLED GDPIVAYYDE
860 870 880 890 900
STGQNFIETY HGTEPGFVDE VRLLGNDVGD SECQQIHVKL RITRSPIIGD
910 920 930 940 950
KFSSRHGQKG ICSQKWPTVD MPFTESGMQP DIIINPHAFP SRMTIGMFIE
960 970 980 990 1000
SLAGKAGACH GLAQDSTPFI YSEQQTAADY FGEQLVKAGY NYHGNEPMYS
1010 1020 1030 1040 1050
GITGQEMKAD IYIGVVYYQR LRHMVSDKFQ VRTTGPIHNL TRQPVKGRKR
1060 1070 1080 1090 1100
AGGIRFGEME RDAVIGHGTS FLMQDRLMNC SDYAQSWVCR DCGSIISIMS
1110 1120 1130 1140 1150
TISMNGVGSA SEVRCRSCAK PALGLEDTSD IWQDGSGKKF VGGTNTTLIA
1160 1170
LPSVFNYLTA ELTAMNIKMM LEVK
Length:1,174
Mass (Da):131,687
Last modified:September 22, 2009 - v2
Checksum:i43D5E6A638F6996A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB66435.2.
PIRiT50394.
RefSeqiNP_595819.2. NM_001021723.3.

Genome annotation databases

EnsemblFungiiSPBP23A10.07.1; SPBP23A10.07.1:pep; SPBP23A10.07.
GeneIDi2541280.
KEGGispo:SPBP23A10.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB66435.2.
PIRiT50394.
RefSeqiNP_595819.2. NM_001021723.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277793. 9 interactions.
IntActiQ9P7X8. 1 interaction.

Proteomic databases

MaxQBiQ9P7X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP23A10.07.1; SPBP23A10.07.1:pep; SPBP23A10.07.
GeneIDi2541280.
KEGGispo:SPBP23A10.07.

Organism-specific databases

EuPathDBiFungiDB:SPBP23A10.07.
PomBaseiSPBP23A10.07. rpa2.

Phylogenomic databases

HOGENOMiHOG000222963.
InParanoidiQ9P7X8.
KOiK03002.
OMAiPGQLYLM.
OrthoDBiEOG092C06IY.
PhylomeDBiQ9P7X8.

Enzyme and pathway databases

ReactomeiR-SPO-73762. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

PROiQ9P7X8.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
IPR009674. Rpa2_dom_4.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF06883. RNA_pol_Rpa2_4. 1 hit.
PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPA2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.