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Protein

Probable mitochondrial-processing peptidase subunit beta

Gene

qcr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66ZincPROSITE-ProRule annotation1
Active sitei69Proton acceptorPROSITE-ProRule annotation1
Metal bindingi70ZincPROSITE-ProRule annotation1
Metal bindingi146ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM16.003

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
PEP
Gene namesi
Name:qcr1
ORF Names:SPBP23A10.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP23A10.15c
PomBaseiSPBP23A10.15c qcr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000026783? – 457Probable mitochondrial-processing peptidase subunit beta
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ9P7X1
PaxDbiQ9P7X1
PRIDEiQ9P7X1

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.By similarity

Protein-protein interaction databases

BioGridi277812, 1 interactor
STRINGi4896.SPBP23A10.15c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7X1
SMRiQ9P7X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000242450
InParanoidiQ9P7X1
KOiK17732
OMAiEDTGSRM
OrthoDBiEOG092C25X9
PhylomeDBiQ9P7X1

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR037718 MPP_beat
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PANTHERiPTHR11851:SF103 PTHR11851:SF103, 1 hit
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P7X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLQNLPKL VRRFATTALP KTETTTLKNG LTVATEHHPY AQTATVLVGV
60 70 80 90 100
DAGSRAETAK NNGAAHFLEH LAFKGTKNRS QKALELEFEN TGAHLNAYTS
110 120 130 140 150
REQTVYYAHA FKNAVPNAVA VLADILTNSS ISASAVERER QVILREQEEV
160 170 180 190 200
DKMADEVVFD HLHATAYQGH PLGRTILGPK ENIESLTRED LLQYIKDNYR
210 220 230 240 250
SDRMIISSAG SISHEELVKL AEKYFGHLEP SAEQLSLGAP RGLKPRFVGS
260 270 280 290 300
EIRARDDDSP TANIAIAVEG MSWKHPDYFT ALVMQAIIGN WDRAMGASPH
310 320 330 340 350
LSSRLSTIVQ QHQLANSFMS FSTSYSDTGL WGIYLVTENL GRIDDLVHFT
360 370 380 390 400
LQNWARLTVA TRAEVERAKA QLRASLLLSL DSTTAIAEDI GRQLLTTGRR
410 420 430 440 450
MSPQEVDLRI GQITEKDVAR VASEMIWDKD IAVSAVGSIE GLLDYNRIRS

SISMNRW
Length:457
Mass (Da):50,737
Last modified:October 1, 2000 - v1
Checksum:iB4978855A8574948
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89E → G in BAA13814 (PubMed:9501991).Curated1
Sequence conflicti111 – 112FK → PQ in BAA13814 (PubMed:9501991).Curated2
Sequence conflicti117N → H in BAA13814 (PubMed:9501991).Curated1
Sequence conflicti446 – 457NRIRS…SMNRW → TVFVAVFL in BAA13814 (PubMed:9501991).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89152 mRNA Translation: BAA13814.1
CU329671 Genomic DNA Translation: CAB66443.1
PIRiT42428
T50402
RefSeqiNP_595827.1, NM_001021731.2

Genome annotation databases

EnsemblFungiiSPBP23A10.15c.1; SPBP23A10.15c.1:pep; SPBP23A10.15c
GeneIDi2541300
KEGGispo:SPBP23A10.15c

Similar proteinsi

Entry informationi

Entry nameiMPPB_SCHPO
AccessioniPrimary (citable) accession number: Q9P7X1
Secondary accession number(s): P78803
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health