Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable mitochondrial-processing peptidase subunit beta

Gene

qcr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66ZincPROSITE-ProRule annotation1
Active sitei69Proton acceptorPROSITE-ProRule annotation1
Metal bindingi70ZincPROSITE-ProRule annotation1
Metal bindingi146ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM16.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
PEP
Gene namesi
Name:qcr1
ORF Names:SPBP23A10.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP23A10.15c.
PomBaseiSPBP23A10.15c. qcr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000026783? – 457Probable mitochondrial-processing peptidase subunit beta
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ9P7X1.
PRIDEiQ9P7X1.

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.By similarity

Protein-protein interaction databases

BioGridi277812. 1 interactor.
MINTiMINT-4706551.

Structurei

3D structure databases

ProteinModelPortaliQ9P7X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000242450.
InParanoidiQ9P7X1.
KOiK17732.
OMAiVATEHSP.
OrthoDBiEOG092C25X9.
PhylomeDBiQ9P7X1.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P7X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLQNLPKL VRRFATTALP KTETTTLKNG LTVATEHHPY AQTATVLVGV
60 70 80 90 100
DAGSRAETAK NNGAAHFLEH LAFKGTKNRS QKALELEFEN TGAHLNAYTS
110 120 130 140 150
REQTVYYAHA FKNAVPNAVA VLADILTNSS ISASAVERER QVILREQEEV
160 170 180 190 200
DKMADEVVFD HLHATAYQGH PLGRTILGPK ENIESLTRED LLQYIKDNYR
210 220 230 240 250
SDRMIISSAG SISHEELVKL AEKYFGHLEP SAEQLSLGAP RGLKPRFVGS
260 270 280 290 300
EIRARDDDSP TANIAIAVEG MSWKHPDYFT ALVMQAIIGN WDRAMGASPH
310 320 330 340 350
LSSRLSTIVQ QHQLANSFMS FSTSYSDTGL WGIYLVTENL GRIDDLVHFT
360 370 380 390 400
LQNWARLTVA TRAEVERAKA QLRASLLLSL DSTTAIAEDI GRQLLTTGRR
410 420 430 440 450
MSPQEVDLRI GQITEKDVAR VASEMIWDKD IAVSAVGSIE GLLDYNRIRS

SISMNRW
Length:457
Mass (Da):50,737
Last modified:October 1, 2000 - v1
Checksum:iB4978855A8574948
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89E → G in BAA13814 (PubMed:9501991).Curated1
Sequence conflicti111 – 112FK → PQ in BAA13814 (PubMed:9501991).Curated2
Sequence conflicti117N → H in BAA13814 (PubMed:9501991).Curated1
Sequence conflicti446 – 457NRIRS…SMNRW → TVFVAVFL in BAA13814 (PubMed:9501991).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89152 mRNA. Translation: BAA13814.1.
CU329671 Genomic DNA. Translation: CAB66443.1.
PIRiT42428.
T50402.
RefSeqiNP_595827.1. NM_001021731.2.

Genome annotation databases

EnsemblFungiiSPBP23A10.15c.1; SPBP23A10.15c.1:pep; SPBP23A10.15c.
GeneIDi2541300.
KEGGispo:SPBP23A10.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89152 mRNA. Translation: BAA13814.1.
CU329671 Genomic DNA. Translation: CAB66443.1.
PIRiT42428.
T50402.
RefSeqiNP_595827.1. NM_001021731.2.

3D structure databases

ProteinModelPortaliQ9P7X1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277812. 1 interactor.
MINTiMINT-4706551.

Protein family/group databases

MEROPSiM16.003.

Proteomic databases

MaxQBiQ9P7X1.
PRIDEiQ9P7X1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP23A10.15c.1; SPBP23A10.15c.1:pep; SPBP23A10.15c.
GeneIDi2541300.
KEGGispo:SPBP23A10.15c.

Organism-specific databases

EuPathDBiFungiDB:SPBP23A10.15c.
PomBaseiSPBP23A10.15c. qcr1.

Phylogenomic databases

HOGENOMiHOG000242450.
InParanoidiQ9P7X1.
KOiK17732.
OMAiVATEHSP.
OrthoDBiEOG092C25X9.
PhylomeDBiQ9P7X1.

Miscellaneous databases

PROiQ9P7X1.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPPB_SCHPO
AccessioniPrimary (citable) accession number: Q9P7X1
Secondary accession number(s): P78803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.