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Protein

F-box/WD repeat-containing protein pof10

Gene

pof10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein pof10
Alternative name(s):
Skp1-binding protein 2
Gene namesi
Name:pof10
Synonyms:sbp2
ORF Names:SPBC1703.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.06
PomBaseiSPBC1703.06 pof10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511371 – 662F-box/WD repeat-containing protein pof10Add BLAST662

Proteomic databases

MaxQBiQ9P7W4
PaxDbiQ9P7W4
PRIDEiQ9P7W4

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with skp1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
skp1Q9Y7095EBI-908406,EBI-1172248

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276318, 19 interactors
IntActiQ9P7W4, 1 interactor
MINTiQ9P7W4
STRINGi4896.SPBC1703.06.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 74F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati215 – 260WD 1Add BLAST46
Repeati263 – 302WD 2Add BLAST40
Repeati429 – 468WD 3Add BLAST40
Domaini581 – 600UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini646 – 662UIM 2PROSITE-ProRule annotationAdd BLAST17

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiQ9P7W4
KOiK15073
OMAiRREPINC
OrthoDBiEOG092C1NBI
PhylomeDBiQ9P7W4

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR003903 UIM_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF50978 SSF50978, 2 hits
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50330 UIM, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSEPTSLDF TSSNLRRMNR DHSSNNTNRT VLNLPKEILI IIFSFLDPRS
60 70 80 90 100
LLSAQCTCKY WKKLLSDDLS WRTAFFHHFA GDQSQIFSPL GNGTWRQEYL
110 120 130 140 150
LRSTITRAYE KGKGQTVQYD CRVGQLTNLY YDFSSGRLYS GNWLTGTISV
160 170 180 190 200
SDPTTGKVER SLLHASTDGS FTHGLSTMTL GKQIFGFGFM DGRVGVILMS
210 220 230 240 250
RQAETPRKFR YCLDSHADSV TCIDALTGDL PPTGEIGMVT GSDDGSVHCW
260 270 280 290 300
DVKTGVSLQS FQFRSSQILS LCFRPKYKML LVDTFNYELN SYQLYLIPGY
310 320 330 340 350
ARSRKNEQPI LLSSRKCVLT DEEEPPCLMT ADCCAGVAFL SRGAPKNCIC
360 370 380 390 400
RVSFKEFLEK NDNVGVQTSS IPLNGKPTSI SLDTNDRVLS KSTPGRGARL
410 420 430 440 450
LAVGDENGLV YVVNTRTEDP NKAILRTITA YSNFPITDIY LNEVAMVVGS
460 470 480 490 500
ASGYCGVYDT VTGNFLKKIA SARNAARREP INCILLDSNP LSLKGVITMS
510 520 530 540 550
KHVKSWSYTI PKPFVNKRSK VLPLRPSVTH DNLSKSSDYS KNEVEREIML
560 570 580 590 600
GLDQIAQERR EKMEARQKFE QHFGEGLVGL SEEEIIAYVT MLSQEEEAKR
610 620 630 640 650
MVQLSMDVDK IEEDFKENDE QATSSLNALS SNHEPPQEQA NVAELNEQEQ
660
IELAMRLSLM EM
Length:662
Mass (Da):74,205
Last modified:October 1, 2000 - v1
Checksum:i44061C20A61F602C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061725 Genomic DNA Translation: BAB55636.1
CU329671 Genomic DNA Translation: CAB66450.1
PIRiT50319
RefSeqiNP_596201.1, NM_001022120.2

Genome annotation databases

EnsemblFungiiSPBC1703.06.1; SPBC1703.06.1:pep; SPBC1703.06
GeneIDi2539767
KEGGispo:SPBC1703.06

Similar proteinsi

Entry informationi

Entry nameiPOF10_SCHPO
AccessioniPrimary (citable) accession number: Q9P7W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health