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Protein

F-box/WD repeat-containing protein pof10

Gene

pof10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein pof10
Alternative name(s):
Skp1-binding protein 2
Gene namesi
Name:pof10
Synonyms:sbp2
ORF Names:SPBC1703.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.06.
PomBaseiSPBC1703.06. pof10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • ubiquitin ligase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662F-box/WD repeat-containing protein pof10PRO_0000051137Add
BLAST

Proteomic databases

MaxQBiQ9P7W4.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with skp1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
skp1Q9Y7095EBI-908406,EBI-1172248

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276318. 19 interactions.
IntActiQ9P7W4. 1 interaction.
MINTiMINT-4706472.

Structurei

3D structure databases

ProteinModelPortaliQ9P7W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 7447F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati215 – 26046WD 1Add
BLAST
Repeati263 – 30240WD 2Add
BLAST
Repeati429 – 46840WD 3Add
BLAST
Domaini581 – 60020UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini646 – 66217UIM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation
Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiQ9P7W4.
KOiK15073.
OMAiRREPINC.
OrthoDBiEOG7H79CQ.
PhylomeDBiQ9P7W4.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR003903. UIM_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50330. UIM. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSEPTSLDF TSSNLRRMNR DHSSNNTNRT VLNLPKEILI IIFSFLDPRS
60 70 80 90 100
LLSAQCTCKY WKKLLSDDLS WRTAFFHHFA GDQSQIFSPL GNGTWRQEYL
110 120 130 140 150
LRSTITRAYE KGKGQTVQYD CRVGQLTNLY YDFSSGRLYS GNWLTGTISV
160 170 180 190 200
SDPTTGKVER SLLHASTDGS FTHGLSTMTL GKQIFGFGFM DGRVGVILMS
210 220 230 240 250
RQAETPRKFR YCLDSHADSV TCIDALTGDL PPTGEIGMVT GSDDGSVHCW
260 270 280 290 300
DVKTGVSLQS FQFRSSQILS LCFRPKYKML LVDTFNYELN SYQLYLIPGY
310 320 330 340 350
ARSRKNEQPI LLSSRKCVLT DEEEPPCLMT ADCCAGVAFL SRGAPKNCIC
360 370 380 390 400
RVSFKEFLEK NDNVGVQTSS IPLNGKPTSI SLDTNDRVLS KSTPGRGARL
410 420 430 440 450
LAVGDENGLV YVVNTRTEDP NKAILRTITA YSNFPITDIY LNEVAMVVGS
460 470 480 490 500
ASGYCGVYDT VTGNFLKKIA SARNAARREP INCILLDSNP LSLKGVITMS
510 520 530 540 550
KHVKSWSYTI PKPFVNKRSK VLPLRPSVTH DNLSKSSDYS KNEVEREIML
560 570 580 590 600
GLDQIAQERR EKMEARQKFE QHFGEGLVGL SEEEIIAYVT MLSQEEEAKR
610 620 630 640 650
MVQLSMDVDK IEEDFKENDE QATSSLNALS SNHEPPQEQA NVAELNEQEQ
660
IELAMRLSLM EM
Length:662
Mass (Da):74,205
Last modified:October 1, 2000 - v1
Checksum:i44061C20A61F602C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061725 Genomic DNA. Translation: BAB55636.1.
CU329671 Genomic DNA. Translation: CAB66450.1.
PIRiT50319.
RefSeqiNP_596201.1. NM_001022120.2.

Genome annotation databases

EnsemblFungiiSPBC1703.06.1; SPBC1703.06.1:pep; SPBC1703.06.
GeneIDi2539767.
KEGGispo:SPBC1703.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061725 Genomic DNA. Translation: BAB55636.1.
CU329671 Genomic DNA. Translation: CAB66450.1.
PIRiT50319.
RefSeqiNP_596201.1. NM_001022120.2.

3D structure databases

ProteinModelPortaliQ9P7W4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276318. 19 interactions.
IntActiQ9P7W4. 1 interaction.
MINTiMINT-4706472.

Proteomic databases

MaxQBiQ9P7W4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1703.06.1; SPBC1703.06.1:pep; SPBC1703.06.
GeneIDi2539767.
KEGGispo:SPBC1703.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.06.
PomBaseiSPBC1703.06. pof10.

Phylogenomic databases

InParanoidiQ9P7W4.
KOiK15073.
OMAiRREPINC.
OrthoDBiEOG7H79CQ.
PhylomeDBiQ9P7W4.

Miscellaneous databases

PROiQ9P7W4.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR003903. UIM_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50330. UIM. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel F-box protein Pof10 in fission yeast."
    Ikebe C., Kominami K., Toda T., Nakayama K.
    Biochem. Biophys. Res. Commun. 290:1399-1407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH SKP1, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint."
    Lehmann A., Katayama S., Harrison C., Dhut S., Kitamura K., McDonald N., Toda T.
    Genes Cells 9:367-382(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKP1.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOF10_SCHPO
AccessioniPrimary (citable) accession number: Q9P7W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.