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Protein

Probable 5-formyltetrahydrofolate cyclo-ligase

Gene

SPBC1703.08c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57SubstrateBy similarity1
Binding sitei102SubstrateBy similarity1
Binding sitei188ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 9ATPBy similarity5
Nucleotide bindingi139 – 146ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-196757 Metabolism of folate and pterines

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-formyltetrahydrofolate cyclo-ligase (EC:6.3.3.2)
Alternative name(s):
5,10-methenyl-tetrahydrofolate synthetase
Short name:
MTHFS
Short name:
Methenyl-THF synthetase
Gene namesi
ORF Names:SPBC1703.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.08c
PomBaseiSPBC1703.08c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002791 – 204Probable 5-formyltetrahydrofolate cyclo-ligaseAdd BLAST204

Proteomic databases

MaxQBiQ9P7W2
PaxDbiQ9P7W2
PRIDEiQ9P7W2

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC1703.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7W2
SMRiQ9P7W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 144Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9P7W2
KOiK01934
OMAiARVFCIT
OrthoDBiEOG092C4TVL
PhylomeDBiQ9P7W2

Family and domain databases

Gene3Di3.40.50.10420, 1 hit
InterProiView protein in InterPro
IPR002698 FTHF_cligase
IPR024185 FTHF_cligase-like_sf
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR23407:SF1 PTHR23407:SF1, 1 hit
PfamiView protein in Pfam
PF01812 5-FTHF_cyc-lig, 1 hit
PIRSFiPIRSF006806 FTHF_cligase, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR02727 MTHFS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKKNQLRA ILNSSLGKLA DHIIDSQSIS ICKQVVELPE WKRCKNVCLY
60 70 80 90 100
MNMPKKEVRT RCLIDVAFKE GKNVFIPKCI GSHVMEMYQV FEKTESLTIN
110 120 130 140 150
KWGIAEPNGE SRKIMDDETD CELIIVPGVA FDEKLSRLGH GKGYYDNYIS
160 170 180 190 200
KYQSWALQKE SRANMFKVGI CLKEQILPNR EIPMDTRDQK LDALVTPEKV

IRNI
Length:204
Mass (Da):23,485
Last modified:October 1, 2000 - v1
Checksum:iEACDD73DEF51E3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB66452.1
PIRiT50321
RefSeqiNP_596203.1, NM_001022122.2

Genome annotation databases

EnsemblFungiiSPBC1703.08c.1; SPBC1703.08c.1:pep; SPBC1703.08c
GeneIDi2539626
KEGGispo:SPBC1703.08c

Similar proteinsi

Entry informationi

Entry nameiFTHC_SCHPO
AccessioniPrimary (citable) accession number: Q9P7W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health