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Protein

Probable 5-formyltetrahydrofolate cyclo-ligase

Gene

SPBC1703.08c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57SubstrateBy similarity1
Binding sitei102SubstrateBy similarity1
Binding sitei188ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 9ATPBy similarity5
Nucleotide bindingi139 – 146ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-196757. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-formyltetrahydrofolate cyclo-ligase (EC:6.3.3.2)
Alternative name(s):
5,10-methenyl-tetrahydrofolate synthetase
Short name:
MTHFS
Short name:
Methenyl-THF synthetase
Gene namesi
ORF Names:SPBC1703.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.08c.
PomBaseiSPBC1703.08c.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002791 – 204Probable 5-formyltetrahydrofolate cyclo-ligaseAdd BLAST204

Proteomic databases

MaxQBiQ9P7W2.
PRIDEiQ9P7W2.

Interactioni

Protein-protein interaction databases

MINTiMINT-4706450.

Structurei

3D structure databases

ProteinModelPortaliQ9P7W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 144Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9P7W2.
KOiK01934.
OMAiLMVRLHH.
OrthoDBiEOG092C4TVL.
PhylomeDBiQ9P7W2.

Family and domain databases

Gene3Di3.40.50.10420. 1 hit.
InterProiIPR002698. FTHF_cligase.
IPR024185. FTHF_cligase-like.
[Graphical view]
PANTHERiPTHR23407:SF1. PTHR23407:SF1. 1 hit.
PfamiPF01812. 5-FTHF_cyc-lig. 1 hit.
[Graphical view]
PIRSFiPIRSF006806. FTHF_cligase. 1 hit.
TIGRFAMsiTIGR02727. MTHFS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P7W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKKNQLRA ILNSSLGKLA DHIIDSQSIS ICKQVVELPE WKRCKNVCLY
60 70 80 90 100
MNMPKKEVRT RCLIDVAFKE GKNVFIPKCI GSHVMEMYQV FEKTESLTIN
110 120 130 140 150
KWGIAEPNGE SRKIMDDETD CELIIVPGVA FDEKLSRLGH GKGYYDNYIS
160 170 180 190 200
KYQSWALQKE SRANMFKVGI CLKEQILPNR EIPMDTRDQK LDALVTPEKV

IRNI
Length:204
Mass (Da):23,485
Last modified:October 1, 2000 - v1
Checksum:iEACDD73DEF51E3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB66452.1.
PIRiT50321.
RefSeqiNP_596203.1. NM_001022122.2.

Genome annotation databases

EnsemblFungiiSPBC1703.08c.1; SPBC1703.08c.1:pep; SPBC1703.08c.
GeneIDi2539626.
KEGGispo:SPBC1703.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB66452.1.
PIRiT50321.
RefSeqiNP_596203.1. NM_001022122.2.

3D structure databases

ProteinModelPortaliQ9P7W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4706450.

Proteomic databases

MaxQBiQ9P7W2.
PRIDEiQ9P7W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1703.08c.1; SPBC1703.08c.1:pep; SPBC1703.08c.
GeneIDi2539626.
KEGGispo:SPBC1703.08c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.08c.
PomBaseiSPBC1703.08c.

Phylogenomic databases

InParanoidiQ9P7W2.
KOiK01934.
OMAiLMVRLHH.
OrthoDBiEOG092C4TVL.
PhylomeDBiQ9P7W2.

Enzyme and pathway databases

ReactomeiR-SPO-196757. Metabolism of folate and pterines.

Miscellaneous databases

PROiQ9P7W2.

Family and domain databases

Gene3Di3.40.50.10420. 1 hit.
InterProiIPR002698. FTHF_cligase.
IPR024185. FTHF_cligase-like.
[Graphical view]
PANTHERiPTHR23407:SF1. PTHR23407:SF1. 1 hit.
PfamiPF01812. 5-FTHF_cyc-lig. 1 hit.
[Graphical view]
PIRSFiPIRSF006806. FTHF_cligase. 1 hit.
TIGRFAMsiTIGR02727. MTHFS_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFTHC_SCHPO
AccessioniPrimary (citable) accession number: Q9P7W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.