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Q9P7V9

- UBP9_SCHPO

UniProt

Q9P7V9 - UBP9_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 9

Gene

ubp9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501NucleophilePROSITE-ProRule annotation
    Active sitei375 – 3751Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: PomBase
    2. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. cellular protein localization Source: PomBase
    2. endocytosis Source: PomBase
    3. protein deubiquitination Source: PomBase
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A62.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 9
    Ubiquitin thioesterase 9
    Ubiquitin-specific-processing protease 9
    Gene namesi
    Name:ubp9
    ORF Names:SPBC1703.12
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1703.12.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Cell septum 1 Publication. Cell tip 1 Publication

    GO - Cellular componenti

    1. cell division site Source: PomBase
    2. cell septum Source: UniProtKB-SubCell
    3. cell tip Source: PomBase
    4. cytoplasm Source: PomBase
    5. cytosol Source: PomBase
    6. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Probable ubiquitin carboxyl-terminal hydrolase 9PRO_0000080610Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei505 – 5051Phosphoserine1 Publication
    Modified residuei549 – 5491Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P7V9.

    Interactioni

    Subunit structurei

    Interacts with bun107 and bun62.1 Publication

    Protein-protein interaction databases

    BioGridi276657. 6 interactions.
    MINTiMINT-4706427.
    STRINGi4896.SPBC1703.12-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P7V9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 424384USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    KOiK11872.
    OMAiCENITSR.
    OrthoDBiEOG7TF7JV.
    PhylomeDBiQ9P7V9.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P7V9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLRWMGMN SPGSTDRRKS TWEAELPKPS IRPETLTDRF YGLTNYGNTC    50
    YVSSVLVSLY HLKPFRDSLN SYPLPSAPPN FKSVCTKTNH PESSSSRHSK 100
    KKSMENRKSS LYGSNGINSC GCVDISNVGS ESGTKHQIVV GESNCSAYGM 150
    KENIYTCLKD LYCSVSCCDC RYGICSPERF IQVLRRDNEA FRSTQQQDAH 200
    EFFNFLLNSV TETLDEYYGN HSDVMHPKWV HSLFEGTLTS ETKCLTCENI 250
    TSRDESFLDL SIDIENHTSV TSCLRSFSAS EMLSSKNKFH CDVCKSLQEA 300
    EKRMKIKKLP KILSLHLKRF KYNETQEGHD KLFYTIVFTN EMRLFTTTED 350
    AENAERMYYL SSVIVHVGGG PHRGHYVSIV RTKTYGWVLF DDENVTPVNE 400
    NYLQRFFGDQ PGQATAYVLF YTAADEEDDD VSEVDTKESI KPMSIPSQLK 450
    QESVEVSNLS STPRSNSTIT YPDMDPMVAS FSSQYSHKTL DRDINSRSYF 500
    DREPSLDAER FHSRSVDASP KAVRRESRSF FPSLTRKRSK FFGSSQSNSP 550
    KDSPLRDTHK SSDEHSESKH SHTLPWQFSR SRSKR 585
    Length:585
    Mass (Da):66,788
    Last modified:October 1, 2000 - v1
    Checksum:iDA4C7951C62E38B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB66456.1.
    PIRiT50325.
    RefSeqiNP_596207.1. NM_001022126.2.

    Genome annotation databases

    EnsemblFungiiSPBC1703.12.1; SPBC1703.12.1:pep; SPBC1703.12.
    GeneIDi2540120.
    KEGGispo:SPBC1703.12.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB66456.1 .
    PIRi T50325.
    RefSeqi NP_596207.1. NM_001022126.2.

    3D structure databases

    ProteinModelPortali Q9P7V9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276657. 6 interactions.
    MINTi MINT-4706427.
    STRINGi 4896.SPBC1703.12-1.

    Protein family/group databases

    MEROPSi C19.A62.

    Proteomic databases

    MaxQBi Q9P7V9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1703.12.1 ; SPBC1703.12.1:pep ; SPBC1703.12 .
    GeneIDi 2540120.
    KEGGi spo:SPBC1703.12.

    Organism-specific databases

    PomBasei SPBC1703.12.

    Phylogenomic databases

    eggNOGi COG5077.
    KOi K11872.
    OMAi CENITSR.
    OrthoDBi EOG7TF7JV.
    PhylomeDBi Q9P7V9.

    Miscellaneous databases

    NextBioi 20801256.
    PROi Q9P7V9.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505 AND SER-549, IDENTIFICATION BY MASS SPECTROMETRY.
    3. "A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity."
      Kouranti I., McLean J.R., Feoktistova A., Liang P., Johnson A.E., Roberts-Galbraith R.H., Gould K.L.
      PLoS Biol. 8:708-716(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BUN107 AND BUN62.

    Entry informationi

    Entry nameiUBP9_SCHPO
    AccessioniPrimary (citable) accession number: Q9P7V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3