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Protein

Probable ubiquitin carboxyl-terminal hydrolase 9

Gene

ubp9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50NucleophilePROSITE-ProRule annotation1
Active sitei375Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: PomBase
  • protein K11-linked deubiquitination Source: PomBase
  • protein K48-linked deubiquitination Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.A62

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene namesi
Name:ubp9
ORF Names:SPBC1703.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.12
PomBaseiSPBC1703.12 ubp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806101 – 585Probable ubiquitin carboxyl-terminal hydrolase 9Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei505Phosphoserine1 Publication1
Modified residuei549Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7V9
PaxDbiQ9P7V9
PRIDEiQ9P7V9

PTM databases

iPTMnetiQ9P7V9

Interactioni

Subunit structurei

Interacts with bun107 and bun62.1 Publication

Protein-protein interaction databases

BioGridi276657, 9 interactors
STRINGi4896.SPBC1703.12.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7V9
SMRiQ9P7V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 424USPAdd BLAST384

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiQ9P7V9
KOiK11872
OMAiLTCENIT
OrthoDBiEOG092C0UAA
PhylomeDBiQ9P7V9

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRWMGMN SPGSTDRRKS TWEAELPKPS IRPETLTDRF YGLTNYGNTC
60 70 80 90 100
YVSSVLVSLY HLKPFRDSLN SYPLPSAPPN FKSVCTKTNH PESSSSRHSK
110 120 130 140 150
KKSMENRKSS LYGSNGINSC GCVDISNVGS ESGTKHQIVV GESNCSAYGM
160 170 180 190 200
KENIYTCLKD LYCSVSCCDC RYGICSPERF IQVLRRDNEA FRSTQQQDAH
210 220 230 240 250
EFFNFLLNSV TETLDEYYGN HSDVMHPKWV HSLFEGTLTS ETKCLTCENI
260 270 280 290 300
TSRDESFLDL SIDIENHTSV TSCLRSFSAS EMLSSKNKFH CDVCKSLQEA
310 320 330 340 350
EKRMKIKKLP KILSLHLKRF KYNETQEGHD KLFYTIVFTN EMRLFTTTED
360 370 380 390 400
AENAERMYYL SSVIVHVGGG PHRGHYVSIV RTKTYGWVLF DDENVTPVNE
410 420 430 440 450
NYLQRFFGDQ PGQATAYVLF YTAADEEDDD VSEVDTKESI KPMSIPSQLK
460 470 480 490 500
QESVEVSNLS STPRSNSTIT YPDMDPMVAS FSSQYSHKTL DRDINSRSYF
510 520 530 540 550
DREPSLDAER FHSRSVDASP KAVRRESRSF FPSLTRKRSK FFGSSQSNSP
560 570 580
KDSPLRDTHK SSDEHSESKH SHTLPWQFSR SRSKR
Length:585
Mass (Da):66,788
Last modified:October 1, 2000 - v1
Checksum:iDA4C7951C62E38B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB66456.1
PIRiT50325
RefSeqiNP_596207.1, NM_001022126.2

Genome annotation databases

EnsemblFungiiSPBC1703.12.1; SPBC1703.12.1:pep; SPBC1703.12
GeneIDi2540120
KEGGispo:SPBC1703.12

Similar proteinsi

Entry informationi

Entry nameiUBP9_SCHPO
AccessioniPrimary (citable) accession number: Q9P7V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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