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Protein

Probable ubiquitin carboxyl-terminal hydrolase 9

Gene

ubp9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50NucleophilePROSITE-ProRule annotation1
Active sitei375Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitinyl hydrolase activity Source: PomBase

GO - Biological processi

  • endocytosis Source: PomBase
  • protein K11-linked deubiquitination Source: PomBase
  • protein K48-linked deubiquitination Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5689880. Ub-specific processing proteases.

Protein family/group databases

MEROPSiC19.A62.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene namesi
Name:ubp9
ORF Names:SPBC1703.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.12.
PomBaseiSPBC1703.12. ubp9.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell septum Source: UniProtKB-SubCell
  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806101 – 585Probable ubiquitin carboxyl-terminal hydrolase 9Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei505Phosphoserine1 Publication1
Modified residuei549Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7V9.
PRIDEiQ9P7V9.

PTM databases

iPTMnetiQ9P7V9.

Interactioni

Subunit structurei

Interacts with bun107 and bun62.1 Publication

Protein-protein interaction databases

BioGridi276657. 9 interactors.
MINTiMINT-4706427.

Structurei

3D structure databases

ProteinModelPortaliQ9P7V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 424USPAdd BLAST384

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

InParanoidiQ9P7V9.
KOiK11872.
OMAiCENITSR.
OrthoDBiEOG092C0UAA.
PhylomeDBiQ9P7V9.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRWMGMN SPGSTDRRKS TWEAELPKPS IRPETLTDRF YGLTNYGNTC
60 70 80 90 100
YVSSVLVSLY HLKPFRDSLN SYPLPSAPPN FKSVCTKTNH PESSSSRHSK
110 120 130 140 150
KKSMENRKSS LYGSNGINSC GCVDISNVGS ESGTKHQIVV GESNCSAYGM
160 170 180 190 200
KENIYTCLKD LYCSVSCCDC RYGICSPERF IQVLRRDNEA FRSTQQQDAH
210 220 230 240 250
EFFNFLLNSV TETLDEYYGN HSDVMHPKWV HSLFEGTLTS ETKCLTCENI
260 270 280 290 300
TSRDESFLDL SIDIENHTSV TSCLRSFSAS EMLSSKNKFH CDVCKSLQEA
310 320 330 340 350
EKRMKIKKLP KILSLHLKRF KYNETQEGHD KLFYTIVFTN EMRLFTTTED
360 370 380 390 400
AENAERMYYL SSVIVHVGGG PHRGHYVSIV RTKTYGWVLF DDENVTPVNE
410 420 430 440 450
NYLQRFFGDQ PGQATAYVLF YTAADEEDDD VSEVDTKESI KPMSIPSQLK
460 470 480 490 500
QESVEVSNLS STPRSNSTIT YPDMDPMVAS FSSQYSHKTL DRDINSRSYF
510 520 530 540 550
DREPSLDAER FHSRSVDASP KAVRRESRSF FPSLTRKRSK FFGSSQSNSP
560 570 580
KDSPLRDTHK SSDEHSESKH SHTLPWQFSR SRSKR
Length:585
Mass (Da):66,788
Last modified:October 1, 2000 - v1
Checksum:iDA4C7951C62E38B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB66456.1.
PIRiT50325.
RefSeqiNP_596207.1. NM_001022126.2.

Genome annotation databases

EnsemblFungiiSPBC1703.12.1; SPBC1703.12.1:pep; SPBC1703.12.
GeneIDi2540120.
KEGGispo:SPBC1703.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB66456.1.
PIRiT50325.
RefSeqiNP_596207.1. NM_001022126.2.

3D structure databases

ProteinModelPortaliQ9P7V9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276657. 9 interactors.
MINTiMINT-4706427.

Protein family/group databases

MEROPSiC19.A62.

PTM databases

iPTMnetiQ9P7V9.

Proteomic databases

MaxQBiQ9P7V9.
PRIDEiQ9P7V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1703.12.1; SPBC1703.12.1:pep; SPBC1703.12.
GeneIDi2540120.
KEGGispo:SPBC1703.12.

Organism-specific databases

EuPathDBiFungiDB:SPBC1703.12.
PomBaseiSPBC1703.12. ubp9.

Phylogenomic databases

InParanoidiQ9P7V9.
KOiK11872.
OMAiCENITSR.
OrthoDBiEOG092C0UAA.
PhylomeDBiQ9P7V9.

Enzyme and pathway databases

ReactomeiR-SPO-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiQ9P7V9.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP9_SCHPO
AccessioniPrimary (citable) accession number: Q9P7V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.