Q9P7V2 (ABC4_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 83.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: ATP-binding cassette transporter abc4 Short name=ABC transporter abc4 EC=3.6.3.44 Alternative name(s): ATP-energized glutathione S-conjugate pump abc4 Glutathione S-conjugate-transporting ATPase abc4 | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||||
| Taxonomic identifier | 284812 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 1469 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Involved in detoxification of xenobiotics, and vacuolar sequestration of glutathione S-conjugates. Together with abc2, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway. Ref.2 |
| Catalytic activity | ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out). UniProtKB Q9C8G9 |
| Subcellular location | Vacuole membrane; Multi-pass membrane protein Potential Ref.2. |
| Disruption phenotype | Cells lacking both abc2 and abc4 show sensitivity to cycloheximide (CHX) and 4-nitroquinoline oxide (4-NQO), and decreased accumulation of monochlorobimane-glutathione (MCIB-GS). Ref.2 |
| Sequence similarities | Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1469 | 1469 | ATP-binding cassette transporter abc4 | PRO_0000331223 | |||||
Regions | |||||||||
| Transmembrane | 21 – 40 | 20 | Helical; Potential | ||||||
| Transmembrane | 55 – 74 | 20 | Helical; Potential | ||||||
| Transmembrane | 94 – 114 | 21 | Helical; Potential | ||||||
| Transmembrane | 121 – 141 | 21 | Helical; Potential | ||||||
| Transmembrane | 160 – 180 | 21 | Helical; Potential | ||||||
| Transmembrane | 189 – 209 | 21 | Helical; Potential | ||||||
| Transmembrane | 296 – 316 | 21 | Helical; Potential | ||||||
| Transmembrane | 337 – 357 | 21 | Helical; Potential | ||||||
| Transmembrane | 412 – 432 | 21 | Helical; Potential | ||||||
| Transmembrane | 441 – 461 | 21 | Helical; Potential | ||||||
| Transmembrane | 524 – 544 | 21 | Helical; Potential | ||||||
| Transmembrane | 553 – 573 | 21 | Helical; Potential | ||||||
| Transmembrane | 894 – 914 | 21 | Helical; Potential | ||||||
| Transmembrane | 936 – 956 | 21 | Helical; Potential | ||||||
| Transmembrane | 1009 – 1029 | 21 | Helical; Potential | ||||||
| Transmembrane | 1033 – 1053 | 21 | Helical; Potential | ||||||
| Transmembrane | 1065 – 1085 | 21 | Helical; Potential | ||||||
| Transmembrane | 1120 – 1140 | 21 | Helical; Potential | ||||||
| Transmembrane | 1148 – 1168 | 21 | Helical; Potential | ||||||
| Domain | 296 – 580 | 285 | ABC transmembrane type-1 1 | ||||||
| Domain | 611 – 840 | 230 | ABC transporter 1 | ||||||
| Domain | 897 – 1176 | 280 | ABC transmembrane type-1 2 | ||||||
| Domain | 1214 – 1453 | 240 | ABC transporter 2 | ||||||
| Nucleotide binding | 648 – 655 | 8 | ATP 1 Potential | ||||||
| Nucleotide binding | 1246 – 1253 | 8 | ATP 2 Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 386 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 510 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 615 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 691 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 790 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 815 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 923 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1007 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1355 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant." Iwaki T., Giga-Hama Y., Takegawa K. Microbiology 152:2309-2321(2006) [PubMed: 16849797] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329670 Genomic DNA. Translation: CAB66463.1. |
| PIR | T50210. |
| RefSeq | NP_594558.1. NM_001019987.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2BBS based on UniProtKB P13569. |
| ProteinModelPortal | Q9P7V2. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPAC30.04c.1; SPAC30.04c.1:pep; SPAC30.04c. |
| GeneID | 2543059. |
| GenomeReviews | Gene locus abc4 in contig CU329670_GR. |
| KEGG | spo:SPAC30.04c. |
| NMPDR | fig|4896.1.peg.4528. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC30.04c. |
Phylogenomic databases | |
| eggNOG | fuNOG05955. |
| GeneTree | EFGT00050000001686. |
| HOGENOM | HBG206983. |
| OMA | REDELAW. |
| OrthoDB | EOG49CTGR. |
Gene expression databases | |
| ArrayExpress | Q9P7V2. |
Family and domain databases | |
| InterPro | IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view] |
| Pfam | PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view] |
| SMART | SM00382. AAA. 2 hits. [Graphical view] |
| SUPFAM | SSF90123. ABC_TM_1. 2 hits. |
| PROSITE | PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ABC4_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q9P7V2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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