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Protein

Hydroxamate-type ferrichrome siderophore peptide synthetase

Gene

sib1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular and extracellular ferrichrome siderophore biosynthesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ferrichrome biosynthetic process Source: PomBase
  • intracellular sequestering of iron ion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxamate-type ferrichrome siderophore peptide synthetase (EC:6.-.-.-)
Gene namesi
Name:sib1
ORF Names:SPAC23G3.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23G3.02c.
PomBaseiSPAC23G3.02c. sib1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003391241 – 4924Hydroxamate-type ferrichrome siderophore peptide synthetaseAdd BLAST4924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei752O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1254O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2206O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3288O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3798O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4439O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ9P7T1.
PRIDEiQ9P7T1.

Interactioni

Protein-protein interaction databases

BioGridi277956. 11 interactors.
MINTiMINT-4706290.

Structurei

3D structure databases

ProteinModelPortaliQ9P7T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini717 – 788Acyl carrier 1PROSITE-ProRule annotationAdd BLAST72
Domaini1222 – 1292Acyl carrier 2PROSITE-ProRule annotationAdd BLAST71
Domaini2174 – 2243Acyl carrier 3PROSITE-ProRule annotationAdd BLAST70
Domaini3256 – 3325Acyl carrier 4PROSITE-ProRule annotationAdd BLAST70
Domaini3755 – 3835Acyl carrier 5PROSITE-ProRule annotationAdd BLAST81
Domaini4403 – 4475Acyl carrier 6PROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 6 acyl carrier domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ9P7T1.
OMAiCADANIR.
OrthoDBiEOG092C005V.
PhylomeDBiQ9P7T1.

Family and domain databases

Gene3Di1.10.1200.10. 5 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00501. AMP-binding. 4 hits.
PF00668. Condensation. 6 hits.
PF00550. PP-binding. 3 hits.
[Graphical view]
SMARTiSM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 4 hits.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00455. AMP_BINDING. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNSNEEDAF STQISQLGPM RPSSDAPYHV LSLPFSHPYS AFLDAWSWLF
60 70 80 90 100
CGITGGEVSF FFFPVSDDVI PNTNPKNCQC YLYHSTNSQL EPLEVFHLHK
110 120 130 140 150
LHSAVFTSRR DPSFADDLFE SSKPCLNQLL SYFSDITAFR SMDVVADIAF
160 170 180 190 200
VCSPNFLTLK WNSSLFDDDL ARLLFFMINS KITNYDLPFS ILNSPCSDLC
210 220 230 240 250
LNSSSLANYL HGCFYHNTLS HPYQDALKFI YEIGDDLEDT FRSFSFLELH
260 270 280 290 300
SLAIKLSKLV TCKNEVVPIM VSHSPALFVG ILAILYSGNA YCPIDVETRT
310 320 330 340 350
ERVHFISKDV DASFAIVSEE FVNRFPNNTI ILKVPEYNES MEIKVDDEIP
360 370 380 390 400
PFPFPESLDS VAYVLYTSGS TGNPKGVAIS HRAATNSIKS HGYLYPMFGL
410 420 430 440 450
ERGDAWLQFA NVTFDVSVFE IFGNWNNGLT LVTSKRQNLI GNLEYLIYDY
460 470 480 490 500
KIAALELTPT VANVISLDEN KELFTSVRML ITIGELLTNR IIDFWGERLV
510 520 530 540 550
NAYGPTEAAI HVTLNPSKAL TTVYLVGVPL QSATICVVSL PTEDSQPHVL
560 570 580 590 600
HEGFLGEVCI AGPQLSSGYI NRPEINAKAF VEVQYNEQTL SIYRTGDLGR
610 620 630 640 650
IINGKLYIFG RIAGDMQIKI RGRRIEIGEI ESKLAPSVDS LAIEKIGDNL
660 670 680 690 700
VAFYVGDEMK LRKHAESHLA SWMCPTKYVG LPGFPRLASG KTDRKALKIQ
710 720 730 740 750
FSASDKHSTD FSSFNQSELL VANVLHEICE KRFNSVVSIS RFSSIFDLGL
760 770 780 790 800
DSLDIVYFVR KIRSLGFEAN PSIVLTSKVV FKIAESLILL KPNEVQSKNN
810 820 830 840 850
FLNKCTPLQK GMLYESFSNN GNLYFNHTVF KIAASPEKVK LAWEKLLDTH
860 870 880 890 900
TILSNGFALD ENEGFTRFIL EKKPPLYSYS KNCLECIQKH FTTKEFDEQF
910 920 930 940 950
LNSGPLDAAV IYDSSNCYLS IVWHHALYDG WSIDIIMQQL FMLIHDRRLT
960 970 980 990 1000
IVPQFEDYVQ ELESLRRLNY KNCISFWKKY LKDFKFKSLS YQREKMGVVE
1010 1020 1030 1040 1050
LSSNISLLSV ENICKQLQTT PLSFFLTAWS TVLSSYLKTN DFLVGTVVSG
1060 1070 1080 1090 1100
RVNSLLPNVD YVIGPCMQTL PVRIKLDDEL SYKNLCQNLF KELSFVLKHS
1110 1120 1130 1140 1150
VMAISDFQEE LLVSNLFESI LIYQQSGIPS VDESFISLIH STDHVEQPLL
1160 1170 1180 1190 1200
IEIEKNKGYK FKLTGYLSSE LLNNLLNDFD KILNFILYNI ESKIQTHASF
1210 1220 1230 1240 1250
NVTITEHNHV ESKARTGFSK REEKLVRSCL SKILGNTVLS ADVFENLQNY
1260 1270 1280 1290 1300
GFDSLCAMRF FSLLRKSSGI GNLKIPNMKS NPTIASLCEL LVLPTETLSA
1310 1320 1330 1340 1350
DNEITFYEVS DIQHEANLDI ESFQYFPCTP MQQALLASSE KNGVEYYYNK
1360 1370 1380 1390 1400
YLFETGKSSQ EEIYLLFKTL LNNLPILRTC FFVTRSKKYP YCQVVLNEPN
1410 1420 1430 1440 1450
FYFQVLPYKG ESLSKYNLAE IPLLDSKKVP IQIFFLQGEN KNYVLFCIHH
1460 1470 1480 1490 1500
VLYDAWAFQL IMDDINHLLR KENPKGSQSM LKFISYLHRY NKNVDLEIWS
1510 1520 1530 1540 1550
KIFLGFKPSK FPELCKDINP EQRTYKCNLS ISLSQIDDLC NGFSFTTSTF
1560 1570 1580 1590 1600
LQCCWAKTLS FLLNSRDICF GNIISGRDVP VDEVVSLVAP TFNSFPLRVL
1610 1620 1630 1640 1650
LDSKLSFAEV CGQLQRLKET LQEHQMTSVQ SICKSLTVKS LFDTVFIIQP
1660 1670 1680 1690 1700
QLLSDRTGPW KLLNESSSMD MRFIIELLLG SDDSPLTLVG TGTGKSGKLV
1710 1720 1730 1740 1750
CNLYKTILKH YVHYGLSTSV PLYTSLEKHN LISRSPSSPP PIHTNFDTNA
1760 1770 1780 1790 1800
DIITLFEKEA NEHPSSIALH FVYNVDKENI YSYKFFSEYS IKASYWLHSI
1810 1820 1830 1840 1850
GIKKNDVVAV FIDKSLDYYS LMLGVLRIGA FFFPLEHCSS LNFAKENLLR
1860 1870 1880 1890 1900
TNVKLLIVDK FLPFEDVNQV EIDKFRQVVD KLPTVEIPNE SRSSAFIFPS
1910 1920 1930 1940 1950
YELAEGLTMM ESSSFMDSII SFIDSTCFPS SSRWFQYAPS STACQMFDCF
1960 1970 1980 1990 2000
MCWFFGCTLI SGPQLFLKNN LKPLLLATHA SHLITTSSIA ASLKGEDIPS
2010 2020 2030 2040 2050
IQRLYCYEGP INNYMIKSWG SRLSYIYAFK PLICSCVPAT EYLESNIMMV
2060 2070 2080 2090 2100
GIPLKGLIFA VVNSDTNTLA PIGSSGELCI ASVKKSGNTM MDSQRVFTFE
2110 2120 2130 2140 2150
NRSYYRTGDI VRILAGGEFE YIKKKSFIFI DSMPLDIEGK INVDKLRDLL
2160 2170 2180 2190 2200
NDDNYIFKVD NDEFPKNDNI LDGFQEKVIL TISDFASIPF EKLSLNTKLS
2210 2220 2230 2240 2250
TIGIDSISAI QLSKDLREIF HLRISALDIL NSSTINSLIR KLKRRRTESH
2260 2270 2280 2290 2300
TRNDKIHESI DQFFKDIRKQ ILIPQTLCDK IEQILPCLAS QCSMLSRFYT
2310 2320 2330 2340 2350
NGGKDYLNYS VFHLQKYNDP LLLRSSWENV ISNVSILRTK FQTTKHKRSP
2360 2370 2380 2390 2400
FCQVTYSKVD IPWSMELHAA SVEKVLNEYL ELQRRDLLQG KNVLPYSLIF
2410 2420 2430 2440 2450
VRTFSQETFL IIIMHHALYD ESSLRKILGL VEKSLNSPIG KFNHEPIVRQ
2460 2470 2480 2490 2500
IELLKANYEE AKAFWIKQLL SFQPTNFPSL TACRIDNEDR MLTKKPCALN
2510 2520 2530 2540 2550
YTNLTKWCNA HDVTLQVLGQ LVWAKILASY CAENYAVFGT VLSGKSVLTD
2560 2570 2580 2590 2600
VDDNIFPTVT TIPCVVKLQG TVEDCLRQLQ KFNLDANKFQ FTSLLDIKKW
2610 2620 2630 2640 2650
LNLGPSEKLF SSLFSIYVDN DIPLKLFNDE CKAQGFIEFP VALEMRFSES
2660 2670 2680 2690 2700
TSELTLNSAV NYIPQAHASL ILDQFNAILT TIFNNPLQQI EILENSLPTQ
2710 2720 2730 2740 2750
LLSIKPAIVG DYPTEIKYLH QFVEYFAQKS PNSCALEFAL DINQDSVQLI
2760 2770 2780 2790 2800
RLTYSELNER ANKLAHNLKS YGFRVGSIIA VYFDKCIEAF ISMLAILKAG
2810 2820 2830 2840 2850
CCFLALDVSA PTERIRYIVT DSTAVLVMST GELYTKLLNA SINVTILDAS
2860 2870 2880 2890 2900
DPGNYSNNIE NPYTKDFEDS NLAYVLYTSG STGKPKGCCL THHNVVQCML
2910 2920 2930 2940 2950
AFQDQFAGEW DTNSRFLAFA SFHFDVSVLE QYFSWSTGIT LVAAPQSLIL
2960 2970 2980 2990 3000
QDLPTAISAL KITHVDLTPS LASILTPKTA PLLRVFITGG EQIKQELLNI
3010 3020 3030 3040 3050
WGDTRVLYNF WGPTELTIGA SAFRKVPKNA KVSNIGPPFP NCSTYILSKE
3060 3070 3080 3090 3100
TKVPVLLGGL GEICMGGNQV AKGYLNLPEQ TDAKFYFDRR FNDRIYHTGD
3110 3120 3130 3140 3150
LGRLLKDNNS LEFCGRTDDQ IKLRGQRIEI GEINAVIKSS SEKILGVYTL
3160 3170 3180 3190 3200
AVVHPVLRKQ QLVAFIHVKG ISASHLIVHD HKDPSLIGFI NSACKASLAK
3210 3220 3230 3240 3250
YMVPSFYVFI SSVPLTPTNK FDKKKVIEEF SRLSLGQLSS FAPAREENDN
3260 3270 3280 3290 3300
EGSNVVEPKL LKIIADFSDV KVTDISPQTS VFELGLDSIS AVALSGLLRK
3310 3320 3330 3340 3350
SGYDNANPSL ILTSSTISNL GFALNTQTNE ELEDSIKVNS IIKLPSCSQF
3360 3370 3380 3390 3400
PFHQYIELIN PCLPLVEGLL FELERSNNEN YYNSFFFLFE KREQADQFIN
3410 3420 3430 3440 3450
NFKLLRKQYE VLRSSFLKSD GEYFQVVWKS DFIAEVDVLN NDSLIKTVRY
3460 3470 3480 3490 3500
SLKCEKGFFL VTVTLFHGIY DGWSLDLLLN DLARLCSRKT LAPRPRYSKI
3510 3520 3530 3540 3550
VRQLLINTSL KKDTKEYWLN LFRSKNIYVP IFQGKLDMAI TLGHKLSISS
3560 3570 3580 3590 3600
AKLSTICRSV LKASVNSALL TSWICFLNSI GAINCVGIVV SGRSEISMDC
3610 3620 3630 3640 3650
LEVMGPLFNT IPFPLFLEKD ESFDCLVRRC QLTLASMIPY HQTSLREIKK
3660 3670 3680 3690 3700
WLRRSELFNV LFTYNLHPSV IKQCEFPWSF SSESTDTGYP LALEIEEDVD
3710 3720 3730 3740 3750
GTMNLHLSSN FKYIGQTEII GLLDSYDCYL SSLLETSNAK ISSRPNVLMP
3760 3770 3780 3790 3800
NQPEVKQYIP NVWNDVLKKL ITILSPKVII TKLDFERDTF VHEFGIDSID
3810 3820 3830 3840 3850
LIWLASKVSE AGIGKLDIGL LMEKPTFYRI LQLLCETSAN HSTSLKHEFG
3860 3870 3880 3890 3900
TLNTLLSKYL TDQDAEDCYP ATPIQSGLLL ETMNQKNLYQ NDVLFSLDAE
3910 3920 3930 3940 3950
ISLEKLQNSW KRLCQKNAIL RTHFAISEDS SEPMVIQIVD KFEARSCLNQ
3960 3970 3980 3990 4000
IKILPSRFTN IEDTLRFLRH DEEAKRFLDP FKNPPYYVQF FEIGAKNYMF
4010 4020 4030 4040 4050
VQMHHSLYDG WSLSLMYDEL MQLYRDEQGN SRKPFKDYII QLYSLKYDYD
4060 4070 4080 4090 4100
FWFKYFENLS IPKPLPFLSN NGKFMSSMMS TVSLPSVRLA CQLYGVSIQS
4110 4120 4130 4140 4150
LVFFTWGYYI ASVLNCPDIV FHTVLSGRTY IEGAETVMGP CMNTIPVRIK
4160 4170 4180 4190 4200
FEGALQTLKK TSRMLINLAK QQHTPLSWIY KTYGNVAAIP MESILVYQHL
4210 4220 4230 4240 4250
PDSSQSETFL NVVTDNSAVD YPIAIQFEIQ GDTLNWLTSL DLARVDGDVA
4260 4270 4280 4290 4300
NQLLQTIDKI FSNLTKGSFE KLTFNFSNFV KYRQYQINLK DFRENLLLTE
4310 4320 4330 4340 4350
EAISDCDLLI IDERVLVVFI LFPEPDAKFP YLVLNEEIIR MLKSYIKKFR
4360 4370 4380 4390 4400
LTLSSAMVPD ILVPVSYLPR SLDHSENEGK LLNIYNSISA DNLKILSAVH
4410 4420 4430 4440 4450
EIHLNETEKI LLEGFSKIIC LPQDSVDISN NFFQLGMDSI RSIHLCSYLR
4460 4470 4480 4490 4500
NKGLNVSVSD ILQHSSIEKL AHYLQYEKKE SSSSFDIASF QLDEYLNTLP
4510 4520 4530 4540 4550
SNIPINLVQK ILPCSAGQMY ALNAWYNTEK KKYFHTFFYT TEEKIELLKL
4560 4570 4580 4590 4600
KLAWAKLVKS SDILRTTFIR SSSPCYPLLQ IVLKSFECPW EHYITDNLHD
4610 4620 4630 4640 4650
TCLKIQKREL VTNTTLQEVP LRIATIETSG KFVFCLTIHH ALYDGWSLDI
4660 4670 4680 4690 4700
MINYLSKMYY DDSLTIVQQN SQLFLSTVLD PAVGLSRKKF WNNYLTNYKP
4710 4720 4730 4740 4750
YTFLEKPSAS QEITLFFPKL FSLDTVYSSV RSRGLTVQSV SFAVFARLLA
4760 4770 4780 4790 4800
NEVKQEDVVF GIYVSGRTLD VDNIDELLFP TFNVVPLRVT DTFRPLGEIA
4810 4820 4830 4840 4850
LEIQSFLNEI SGNLQYISLL DLPVHGMMDI AVNFLSTGDN NEPSKVFSVY
4860 4870 4880 4890 4900
PLKLNNAELK INEVETTIDG CEILFGNKPK LDFELAIRDG YLEIGLFCQS
4910 4920
SIFSKREASV FINNFVTIIK EIEL
Length:4,924
Mass (Da):559,849
Last modified:October 1, 2000 - v1
Checksum:i985D30FED3406E2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB72227.1.
PIRiT50176.
RefSeqiNP_593102.1. NM_001018499.2.

Genome annotation databases

EnsemblFungiiSPAC23G3.02c.1; SPAC23G3.02c.1:pep; SPAC23G3.02c.
GeneIDi2541451.
KEGGispo:SPAC23G3.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB72227.1.
PIRiT50176.
RefSeqiNP_593102.1. NM_001018499.2.

3D structure databases

ProteinModelPortaliQ9P7T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277956. 11 interactors.
MINTiMINT-4706290.

Proteomic databases

MaxQBiQ9P7T1.
PRIDEiQ9P7T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23G3.02c.1; SPAC23G3.02c.1:pep; SPAC23G3.02c.
GeneIDi2541451.
KEGGispo:SPAC23G3.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC23G3.02c.
PomBaseiSPAC23G3.02c. sib1.

Phylogenomic databases

InParanoidiQ9P7T1.
OMAiCADANIR.
OrthoDBiEOG092C005V.
PhylomeDBiQ9P7T1.

Miscellaneous databases

PROiQ9P7T1.

Family and domain databases

Gene3Di1.10.1200.10. 5 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00501. AMP-binding. 4 hits.
PF00668. Condensation. 6 hits.
PF00550. PP-binding. 3 hits.
[Graphical view]
SMARTiSM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 4 hits.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00455. AMP_BINDING. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIB1_SCHPO
AccessioniPrimary (citable) accession number: Q9P7T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.