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Q9P7S5

- UBP7_SCHPO

UniProt

Q9P7S5 - UBP7_SCHPO

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Protein

Probable ubiquitin carboxyl-terminal hydrolase 7

Gene

ubp7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171NucleophilePROSITE-ProRule annotation
Active sitei812 – 8121Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri81 – 14969UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein deubiquitination Source: PomBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:ubp7
ORF Names:SPAC23G3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC23G3.08c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Probable ubiquitin carboxyl-terminal hydrolase 7PRO_0000080608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Phosphoserine1 Publication
Modified residuei337 – 3371Phosphoserine1 Publication
Modified residuei486 – 4861Phosphoserine1 Publication
Modified residuei493 – 4931Phosphoserine1 Publication
Modified residuei645 – 6451Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7S5.

Interactioni

Protein-protein interaction databases

BioGridi278336. 16 interactions.
MINTiMINT-4706238.
STRINGi4896.SPAC23G3.08c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P7S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 875668USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri81 – 14969UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiQ9P7S5.
KOiK11844.
OMAiFACENCC.
OrthoDBiEOG7PCJV3.
PhylomeDBiQ9P7S5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7S5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHSNTLIVP STNPFDDPSS IKNGLNNLTS SELVNQMKKE SLAASVKTPS
60 70 80 90 100
TPPKECSHLK KGVKLSHLKG NARALRDPSK HLCFICTTEK IKREDYELTL
110 120 130 140 150
CANCGYLFCC NHESDHSRKH FEKNKKHCVF VNIITLKCHC YSCDADIVIF
160 170 180 190 200
DKKNLVVRDV QQFICSNLVS SLTKAPNVLK SNSSHFKKEK KSKHSSGKSS
210 220 230 240 250
KKYKVISPGL KNLGATCFFN STLQVLCACE ALHDVISPFQ YSHSSVIVRK
260 270 280 290 300
LTKSPESSLL SAFIKFLETF YKSDGTISVY RPTTFFGEFR RLHPQFSESV
310 320 330 340 350
QQDAHELLRL LLDDLISEEF RVLRFNLNSV SRSLQLSPCL TDDEQLSKSL
360 370 380 390 400
TSFKQVNVTD ASLSPNSHNT SDNEQNNEDY VSVSSLVGSE TEDITYSKEL
410 420 430 440 450
SQSSDSSQHQ HDSFLPANSS PLAASSTKSL PSSELLDSSS DKGQQVFKGQ
460 470 480 490 500
HEVAGTNSFE DPNSHFNVSN SSNHEEASPK KEVLKSPQFQ RRSLDILRLG
510 520 530 540 550
ELSSDDMMLD KATMDEFSSS LVIKSIFTGR LTSVVMCQSC NEITNTPEPI
560 570 580 590 600
QDLSIPIHYP SSRVSRRHRF HRALRSRFSR SPKKSSVKIV VDNANDDTDQ
610 620 630 640 650
APTTNSSSLN ENLLGGHASE NDKSLKQSPF QKLTRRLSDL SVNSSGQISK
660 670 680 690 700
QDFDNSNSIF SESSLSSPII EEPKTLIDCL KNFTHVEELS GENMFACENC
710 720 730 740 750
CNQPNEVGSP AKGGLTSDND KYSFNNSVYR NAYKRMLLDD PLPPVFIIHL
760 770 780 790 800
KRFFQEISHD GYANPKKISD FIEFEQELDL NEFVMPHLRA SSSFRYRLFG
810 820 830 840 850
VIVHSGTLNY GHYVAYVLSH KFLDLSAPST NSKDFRSEAG IPERRWLYIS
860 870
DNIVRESSWD EVSKVEAYML FYERV
Length:875
Mass (Da):98,377
Last modified:October 1, 2000 - v1
Checksum:iB4E4CFAC9A440D54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB72233.1.
PIRiT50182.
RefSeqiNP_593108.1. NM_001018505.2.

Genome annotation databases

EnsemblFungiiSPAC23G3.08c.1; SPAC23G3.08c.1:pep; SPAC23G3.08c.
GeneIDi2541845.
KEGGispo:SPAC23G3.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB72233.1 .
PIRi T50182.
RefSeqi NP_593108.1. NM_001018505.2.

3D structure databases

ProteinModelPortali Q9P7S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278336. 16 interactions.
MINTi MINT-4706238.
STRINGi 4896.SPAC23G3.08c-1.

Proteomic databases

MaxQBi Q9P7S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC23G3.08c.1 ; SPAC23G3.08c.1:pep ; SPAC23G3.08c .
GeneIDi 2541845.
KEGGi spo:SPAC23G3.08c.

Organism-specific databases

PomBasei SPAC23G3.08c.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi Q9P7S5.
KOi K11844.
OMAi FACENCC.
OrthoDBi EOG7PCJV3.
PhylomeDBi Q9P7S5.

Miscellaneous databases

NextBioi 20802933.
PROi Q9P7S5.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-337; SER-486; SER-493 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiUBP7_SCHPO
AccessioniPrimary (citable) accession number: Q9P7S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3