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Protein

Probable ubiquitin carboxyl-terminal hydrolase 7

Gene

ubp7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei217NucleophilePROSITE-ProRule annotation1
Active sitei812Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 149UBP-typePROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: PomBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein deubiquitination Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:ubp7
ORF Names:SPAC23G3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23G3.08c.
PomBaseiSPAC23G3.08c. ubp7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806081 – 875Probable ubiquitin carboxyl-terminal hydrolase 7Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333Phosphoserine1 Publication1
Modified residuei337Phosphoserine1 Publication1
Modified residuei486Phosphoserine1 Publication1
Modified residuei493Phosphoserine1 Publication1
Modified residuei645Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7S5.
PRIDEiQ9P7S5.

PTM databases

iPTMnetiQ9P7S5.

Interactioni

Protein-protein interaction databases

BioGridi278336. 16 interactors.
MINTiMINT-4706238.

Structurei

3D structure databases

ProteinModelPortaliQ9P7S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 875USPAdd BLAST668

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 149UBP-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ9P7S5.
KOiK11844.
OMAiFACENCC.
OrthoDBiEOG092C1E9C.
PhylomeDBiQ9P7S5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSNTLIVP STNPFDDPSS IKNGLNNLTS SELVNQMKKE SLAASVKTPS
60 70 80 90 100
TPPKECSHLK KGVKLSHLKG NARALRDPSK HLCFICTTEK IKREDYELTL
110 120 130 140 150
CANCGYLFCC NHESDHSRKH FEKNKKHCVF VNIITLKCHC YSCDADIVIF
160 170 180 190 200
DKKNLVVRDV QQFICSNLVS SLTKAPNVLK SNSSHFKKEK KSKHSSGKSS
210 220 230 240 250
KKYKVISPGL KNLGATCFFN STLQVLCACE ALHDVISPFQ YSHSSVIVRK
260 270 280 290 300
LTKSPESSLL SAFIKFLETF YKSDGTISVY RPTTFFGEFR RLHPQFSESV
310 320 330 340 350
QQDAHELLRL LLDDLISEEF RVLRFNLNSV SRSLQLSPCL TDDEQLSKSL
360 370 380 390 400
TSFKQVNVTD ASLSPNSHNT SDNEQNNEDY VSVSSLVGSE TEDITYSKEL
410 420 430 440 450
SQSSDSSQHQ HDSFLPANSS PLAASSTKSL PSSELLDSSS DKGQQVFKGQ
460 470 480 490 500
HEVAGTNSFE DPNSHFNVSN SSNHEEASPK KEVLKSPQFQ RRSLDILRLG
510 520 530 540 550
ELSSDDMMLD KATMDEFSSS LVIKSIFTGR LTSVVMCQSC NEITNTPEPI
560 570 580 590 600
QDLSIPIHYP SSRVSRRHRF HRALRSRFSR SPKKSSVKIV VDNANDDTDQ
610 620 630 640 650
APTTNSSSLN ENLLGGHASE NDKSLKQSPF QKLTRRLSDL SVNSSGQISK
660 670 680 690 700
QDFDNSNSIF SESSLSSPII EEPKTLIDCL KNFTHVEELS GENMFACENC
710 720 730 740 750
CNQPNEVGSP AKGGLTSDND KYSFNNSVYR NAYKRMLLDD PLPPVFIIHL
760 770 780 790 800
KRFFQEISHD GYANPKKISD FIEFEQELDL NEFVMPHLRA SSSFRYRLFG
810 820 830 840 850
VIVHSGTLNY GHYVAYVLSH KFLDLSAPST NSKDFRSEAG IPERRWLYIS
860 870
DNIVRESSWD EVSKVEAYML FYERV
Length:875
Mass (Da):98,377
Last modified:October 1, 2000 - v1
Checksum:iB4E4CFAC9A440D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB72233.1.
PIRiT50182.
RefSeqiNP_593108.1. NM_001018505.2.

Genome annotation databases

EnsemblFungiiSPAC23G3.08c.1; SPAC23G3.08c.1:pep; SPAC23G3.08c.
GeneIDi2541845.
KEGGispo:SPAC23G3.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB72233.1.
PIRiT50182.
RefSeqiNP_593108.1. NM_001018505.2.

3D structure databases

ProteinModelPortaliQ9P7S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278336. 16 interactors.
MINTiMINT-4706238.

PTM databases

iPTMnetiQ9P7S5.

Proteomic databases

MaxQBiQ9P7S5.
PRIDEiQ9P7S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23G3.08c.1; SPAC23G3.08c.1:pep; SPAC23G3.08c.
GeneIDi2541845.
KEGGispo:SPAC23G3.08c.

Organism-specific databases

EuPathDBiFungiDB:SPAC23G3.08c.
PomBaseiSPAC23G3.08c. ubp7.

Phylogenomic databases

InParanoidiQ9P7S5.
KOiK11844.
OMAiFACENCC.
OrthoDBiEOG092C1E9C.
PhylomeDBiQ9P7S5.

Miscellaneous databases

PROiQ9P7S5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP7_SCHPO
AccessioniPrimary (citable) accession number: Q9P7S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.