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Q9P7S5

- UBP7_SCHPO

UniProt

Q9P7S5 - UBP7_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 7

Gene

ubp7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei217 – 2171NucleophilePROSITE-ProRule annotation
    Active sitei812 – 8121Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri81 – 14969UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 7
    Ubiquitin thioesterase 7
    Ubiquitin-specific-processing protease 7
    Gene namesi
    Name:ubp7
    ORF Names:SPAC23G3.08c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC23G3.08c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Probable ubiquitin carboxyl-terminal hydrolase 7PRO_0000080608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Phosphoserine1 Publication
    Modified residuei337 – 3371Phosphoserine1 Publication
    Modified residuei486 – 4861Phosphoserine1 Publication
    Modified residuei493 – 4931Phosphoserine1 Publication
    Modified residuei645 – 6451Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P7S5.

    Interactioni

    Protein-protein interaction databases

    BioGridi278336. 16 interactions.
    MINTiMINT-4706238.
    STRINGi4896.SPAC23G3.08c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P7S5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini208 – 875668USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri81 – 14969UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5533.
    KOiK11844.
    OMAiFACENCC.
    OrthoDBiEOG7PCJV3.
    PhylomeDBiQ9P7S5.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P7S5-1 [UniParc]FASTAAdd to Basket

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    MPHSNTLIVP STNPFDDPSS IKNGLNNLTS SELVNQMKKE SLAASVKTPS    50
    TPPKECSHLK KGVKLSHLKG NARALRDPSK HLCFICTTEK IKREDYELTL 100
    CANCGYLFCC NHESDHSRKH FEKNKKHCVF VNIITLKCHC YSCDADIVIF 150
    DKKNLVVRDV QQFICSNLVS SLTKAPNVLK SNSSHFKKEK KSKHSSGKSS 200
    KKYKVISPGL KNLGATCFFN STLQVLCACE ALHDVISPFQ YSHSSVIVRK 250
    LTKSPESSLL SAFIKFLETF YKSDGTISVY RPTTFFGEFR RLHPQFSESV 300
    QQDAHELLRL LLDDLISEEF RVLRFNLNSV SRSLQLSPCL TDDEQLSKSL 350
    TSFKQVNVTD ASLSPNSHNT SDNEQNNEDY VSVSSLVGSE TEDITYSKEL 400
    SQSSDSSQHQ HDSFLPANSS PLAASSTKSL PSSELLDSSS DKGQQVFKGQ 450
    HEVAGTNSFE DPNSHFNVSN SSNHEEASPK KEVLKSPQFQ RRSLDILRLG 500
    ELSSDDMMLD KATMDEFSSS LVIKSIFTGR LTSVVMCQSC NEITNTPEPI 550
    QDLSIPIHYP SSRVSRRHRF HRALRSRFSR SPKKSSVKIV VDNANDDTDQ 600
    APTTNSSSLN ENLLGGHASE NDKSLKQSPF QKLTRRLSDL SVNSSGQISK 650
    QDFDNSNSIF SESSLSSPII EEPKTLIDCL KNFTHVEELS GENMFACENC 700
    CNQPNEVGSP AKGGLTSDND KYSFNNSVYR NAYKRMLLDD PLPPVFIIHL 750
    KRFFQEISHD GYANPKKISD FIEFEQELDL NEFVMPHLRA SSSFRYRLFG 800
    VIVHSGTLNY GHYVAYVLSH KFLDLSAPST NSKDFRSEAG IPERRWLYIS 850
    DNIVRESSWD EVSKVEAYML FYERV 875
    Length:875
    Mass (Da):98,377
    Last modified:October 1, 2000 - v1
    Checksum:iB4E4CFAC9A440D54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB72233.1.
    PIRiT50182.
    RefSeqiNP_593108.1. NM_001018505.2.

    Genome annotation databases

    EnsemblFungiiSPAC23G3.08c.1; SPAC23G3.08c.1:pep; SPAC23G3.08c.
    GeneIDi2541845.
    KEGGispo:SPAC23G3.08c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB72233.1 .
    PIRi T50182.
    RefSeqi NP_593108.1. NM_001018505.2.

    3D structure databases

    ProteinModelPortali Q9P7S5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278336. 16 interactions.
    MINTi MINT-4706238.
    STRINGi 4896.SPAC23G3.08c-1.

    Proteomic databases

    MaxQBi Q9P7S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC23G3.08c.1 ; SPAC23G3.08c.1:pep ; SPAC23G3.08c .
    GeneIDi 2541845.
    KEGGi spo:SPAC23G3.08c.

    Organism-specific databases

    PomBasei SPAC23G3.08c.

    Phylogenomic databases

    eggNOGi COG5533.
    KOi K11844.
    OMAi FACENCC.
    OrthoDBi EOG7PCJV3.
    PhylomeDBi Q9P7S5.

    Miscellaneous databases

    NextBioi 20802933.
    PROi Q9P7S5.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-337; SER-486; SER-493 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiUBP7_SCHPO
    AccessioniPrimary (citable) accession number: Q9P7S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3