Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme E2 8

Gene

ubc8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 8 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 8
Ubiquitin carrier protein 8
Ubiquitin-protein ligase 8
Gene namesi
Name:ubc8
ORF Names:SPBC211.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC211.07c
PomBaseiSPBC211.07c ubc8

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003107431 – 184Ubiquitin-conjugating enzyme E2 8Add BLAST184

Proteomic databases

MaxQBiQ9P7R4
PaxDbiQ9P7R4
PRIDEiQ9P7R4

PTM databases

iPTMnetiQ9P7R4

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277261, 4 interactors
STRINGi4896.SPBC211.07c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7R4
SMRiQ9P7R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233452
InParanoidiQ9P7R4
KOiK10576
OMAiNLVNDNM
OrthoDBiEOG092C50OL
PhylomeDBiQ9P7R4

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPRRRIET DVMKLLMSDY EVTLVNDNMQ EFYVRFHGPS ETPYSGGIWK
60 70 80 90 100
VHVELPSEYP WKSPSIGFVN RIFHPNIDEL SGSVCLDVIN QTWSPMFDMI
110 120 130 140 150
NIFEVFLPQL LRYPNASDPL NGEAAALLLR EPNTYYAKVR DYIARYANKE
160 170 180
DADITLNDSS DDDTMSSIDT ESGDEIAGPM DSDF
Length:184
Mass (Da):20,990
Last modified:October 1, 2000 - v1
Checksum:iA07A925FD586B7B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB75415.1
PIRiT50342
RefSeqiNP_596617.1, NM_001022538.2

Genome annotation databases

EnsemblFungiiSPBC211.07c.1; SPBC211.07c.1:pep; SPBC211.07c
GeneIDi2540738
KEGGispo:SPBC211.07c

Similar proteinsi

Entry informationi

Entry nameiUBC8_SCHPO
AccessioniPrimary (citable) accession number: Q9P7R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health