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Protein

Exosome complex component mtr3

Gene

mtr3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-429958. mRNA decay by 3' to 5' exoribonuclease.
R-SPO-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component mtr3
Gene namesi
Name:mtr3
ORF Names:SPBC211.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC211.08c.
PomBaseiSPBC211.08c. mtr3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic exosome (RNase complex) Source: PomBase
  • cytosol Source: PomBase
  • exosome (RNase complex) Source: PomBase
  • nuclear exosome (RNase complex) Source: PomBase
  • nucleolus Source: GO_Central
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172111 – 257Exosome complex component mtr3Add BLAST257

Proteomic databases

MaxQBiQ9P7R3.
PRIDEiQ9P7R3.

Interactioni

Subunit structurei

Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits dis3 and rrp6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components csl4, rrp4 and rrp40 located on the top of the ring structure (By similarity).By similarity

Protein-protein interaction databases

BioGridi276940. 6 interactors.
MINTiMINT-4706146.

Structurei

3D structure databases

ProteinModelPortaliQ9P7R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

HOGENOMiHOG000229515.
InParanoidiQ9P7R3.
KOiK12587.
OMAiADANIDC.
OrthoDBiEOG092C4NRQ.
PhylomeDBiQ9P7R3.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P7R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKRVYGP SVSVPPYFEE PEQPVFTRTR DVDRCRKIYL KLGWATKAVG
60 70 80 90 100
SSYFESEKIK IACTVSGPRP SKTFAFRSSA KLNCEFRLSP FSTSVRQGHV
110 120 130 140 150
QTVEEKSYSQ MIEAAISPSI LLHLYPKSSI DVYIQVIESD GALATLAAAI
160 170 180 190 200
SCASSAIADA NIDCIDLVTG SSVLFNPNTD EYWIDPDYVD ERARAAKGSV
210 220 230 240 250
VMGYMASLGH VTQVWERGTC SPSRLSFLTE KCIKNAKDTR LVINHALLLE

KSKSEDP
Length:257
Mass (Da):28,435
Last modified:October 1, 2000 - v1
Checksum:i9ADA25BADDA8E43A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB75416.1.
PIRiT50343.
RefSeqiNP_596618.1. NM_001022539.2.

Genome annotation databases

EnsemblFungiiSPBC211.08c.1; SPBC211.08c.1:pep; SPBC211.08c.
GeneIDi2540412.
KEGGispo:SPBC211.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB75416.1.
PIRiT50343.
RefSeqiNP_596618.1. NM_001022539.2.

3D structure databases

ProteinModelPortaliQ9P7R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276940. 6 interactors.
MINTiMINT-4706146.

Proteomic databases

MaxQBiQ9P7R3.
PRIDEiQ9P7R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC211.08c.1; SPBC211.08c.1:pep; SPBC211.08c.
GeneIDi2540412.
KEGGispo:SPBC211.08c.

Organism-specific databases

EuPathDBiFungiDB:SPBC211.08c.
PomBaseiSPBC211.08c. mtr3.

Phylogenomic databases

HOGENOMiHOG000229515.
InParanoidiQ9P7R3.
KOiK12587.
OMAiADANIDC.
OrthoDBiEOG092C4NRQ.
PhylomeDBiQ9P7R3.

Enzyme and pathway databases

ReactomeiR-SPO-429958. mRNA decay by 3' to 5' exoribonuclease.
R-SPO-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ9P7R3.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTR3_SCHPO
AccessioniPrimary (citable) accession number: Q9P7R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.