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Protein

Peroxide stress-activated histidine kinase mak1

Gene

mak1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation.2 Publications

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • negative regulation of induction of conjugation with cellular fusion Source: PomBase
  • phosphorelay signal transduction system Source: PomBase
  • stress-activated protein kinase signaling cascade Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxide stress-activated histidine kinase mak1 (EC:2.7.13.3)
Alternative name(s):
His-Asp phosphorelay kinase phk3
Mcs4-associated kinase 1
Gene namesi
Name:mak1
Synonyms:phk3
ORF Names:SPAC1834.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1834.08.
PomBaseiSPAC1834.08. mak1.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16391639Peroxide stress-activated histidine kinase mak1PRO_0000081408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1003 – 10031Phosphohistidine; by autocatalysisPROSITE-ProRule annotation
Modified residuei1559 – 155914-aspartylphosphatePROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7Q7.

Interactioni

Protein-protein interaction databases

BioGridi278595. 30 interactions.
MINTiMINT-4706062.

Structurei

3D structure databases

ProteinModelPortaliQ9P7Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini716 – 78671PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini789 – 84153PAC 1PROSITE-ProRule annotationAdd
BLAST
Domaini848 – 92073PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini929 – 98254PAC 2PROSITE-ProRule annotationAdd
BLAST
Domaini1000 – 1223224Histidine kinasePROSITE-ProRule annotationAdd
BLAST
Domaini1507 – 1629123Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 2 PAC (PAS-associated C-terminal) domains.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ9P7Q7.
OrthoDBiEOG092C08HK.
PhylomeDBiQ9P7Q7.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013655. PAS_fold_3.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF08447. PAS_3. 1 hit.
PF13188. PAS_8. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 2 hits.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPDDQINN NVGSNSHLEK LKEAMDHQLQ KSSKIVGSFT NSQNSSVGSV
60 70 80 90 100
HSPILESPTS LNRQHRNSFS FNNVSSPSLE DERLINFPRV NPNRLMTSKR
110 120 130 140 150
PNELFKTSSM SSDCYSPQKS RESLNSLCHS PAPSVSSCGN ALNNDNTSAS
160 170 180 190 200
HSLTDEQPFE TDSSANLFKQ LQEKRNRTIG NVYEMACLLV FKTGLMNFWK
210 220 230 240 250
NIIDFFAQQF FSTQISVVEP RDLSDIYNTP WQLRCYYDGG SHYDPYSNPI
260 270 280 290 300
SVNDNLASSS YVTVVASDGS KGIIYKDPAS LKHEGDLLID SKVVQTVLER
310 320 330 340 350
ATLLVYTRKQ QHIVKNTKVH DNDYFSSIPN VDDIRSIKNS WKVFHDEKLN
360 370 380 390 400
ELKKQVEISA SAAQLNGLYP QKKRAFVSHF SQNRKPYSQS DISKAQSSSF
410 420 430 440 450
SEEPSNIYDE YEQNLLSPWS RSPVASPSIQ TDPNRNPFFQ NCLQESSFAT
460 470 480 490 500
ESSTEKSASE SVSETAVNDD CKGMNFSGNR RQEDHLNDFT SFPTETAVSI
510 520 530 540 550
VHVPLMFPCS DQTSSRGRAP IAILSFKSNL VPYPENLIAS IERLIPFIFS
560 570 580 590 600
SYSNSQSVPL LPCPTQRHLL FNTSSTDNTK ELSMSASSEN SDCPHKEGEC
610 620 630 640 650
VGSFCNINAK GSSLNNIPKL PRFVPVPSEF FKKNQRSWVT LKKHRLLARL
660 670 680 690 700
KSRISKKNSK VNENLRFSLN DGENYSNETI TLKKDEIVLD KSKSYACCTS
710 720 730 740 750
ESHKYVQGHC GGQAPPFPLL KVIIDSIPVH VFTADPGSGK LTWVNRKTLL
760 770 780 790 800
YCGLNMNEQI ELQFSRIHPD DLPNFLNDWK SSLFSGSGFY HEIRLQRFDN
810 820 830 840 850
VYRYFICRAV PLRDCTGSVL HFFGTMTDVH DQKLAERELQ KQSAIAANEN
860 870 880 890 900
SYRSLAEASP QIVFAANGKN GIIYANAQWL SYSGLSLESS LGLGFLSAVY
910 920 930 940 950
HADRKKCLLP ESLEGTFNNQ DESNGTKTFA AEIRFRSTDG HYRWHLVKSV
960 970 980 990 1000
CVNNSADTST NLWLGTCTDI HDHKMLEEKL QESNIEAQRI VRSKMQYLSN
1010 1020 1030 1040 1050
MSHEIRTPLI GITGMVSFLL ETQMSAEQLS YARIIQQSAK SLLTVINDIL
1060 1070 1080 1090 1100
DLSKVRAGMM KLTSQRFSVR AMMEDANETL GTLAFSKGIE LNYTVDIDVP
1110 1120 1130 1140 1150
DIVFGDNMRM RQVALNVIGN AIKFTNVGEV FTRCSVEKID YSTNTVVLKW
1160 1170 1180 1190 1200
ECIDTGQGFN RDDQLQMFKP FSQVESSTLP RHGGSGLGLV ISKELVELHN
1210 1220 1230 1240 1250
GSMSCQSRRG VGTRFMWTAT FTMDKTPLKF EPPDGCCPVC FCPYEKSKQS
1260 1270 1280 1290 1300
TEDYYCADDG NDKSATNFVK LAVNKADPGR ESNRRKLESD KNVQSNKYVN
1310 1320 1330 1340 1350
PFASESEFCR CGASADPYTV LFWRLYRNKP SGIKLDKSAL AVVVSHTKYS
1360 1370 1380 1390 1400
SEAIGNMLQS IIDISSFKDI VRYGNTYEAF EELLENPMQS KVTHIILNLP
1410 1420 1430 1440 1450
DIEAYVLFVK SLQLCSLYKD TKFILVTSTR QKESLSKIFS DSEDCNSESI
1460 1470 1480 1490 1500
HYVLKLVKPS KFFPLFYSDS EEKGKIGALN DMTRKAAMEQ KADAETLRYN
1510 1520 1530 1540 1550
LAKSGFSVLL AEDNIINIKV ISRYLERIGV KFKVTMDGLQ CVEEWKREKP
1560 1570 1580 1590 1600
NFYSLILMDL QMPVMDGYQA CNEIRKYELE NDYPKVPIVA LSANALPHVV
1610 1620 1630
LSCKDSGFDS YLAKPITLQH LSLIISGILN YTNQSKLHK
Length:1,639
Mass (Da):184,580
Last modified:October 1, 2000 - v1
Checksum:i6A653BA0F3B357B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB75776.1.
PIRiT50119.
RefSeqiNP_594687.1. NM_001020116.2.

Genome annotation databases

EnsemblFungiiSPAC1834.08.1; SPAC1834.08.1:pep; SPAC1834.08.
GeneIDi2542119.
KEGGispo:SPAC1834.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB75776.1.
PIRiT50119.
RefSeqiNP_594687.1. NM_001020116.2.

3D structure databases

ProteinModelPortaliQ9P7Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278595. 30 interactions.
MINTiMINT-4706062.

Proteomic databases

MaxQBiQ9P7Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1834.08.1; SPAC1834.08.1:pep; SPAC1834.08.
GeneIDi2542119.
KEGGispo:SPAC1834.08.

Organism-specific databases

EuPathDBiFungiDB:SPAC1834.08.
PomBaseiSPAC1834.08. mak1.

Phylogenomic databases

InParanoidiQ9P7Q7.
OrthoDBiEOG092C08HK.
PhylomeDBiQ9P7Q7.

Miscellaneous databases

PROiQ9P7Q7.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013655. PAS_fold_3.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF08447. PAS_3. 1 hit.
PF13188. PAS_8. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 2 hits.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAK1_SCHPO
AccessioniPrimary (citable) accession number: Q9P7Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.