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Protein

Vesicular-fusion protein sec18

Gene

sec18

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi311 – 318ATPSequence analysis8
Nucleotide bindingi592 – 599ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-SPO-6807878. COPI-mediated anterograde transport.
R-SPO-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular-fusion protein sec18
Gene namesi
Name:sec18
ORF Names:SPAC1834.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1834.11c.
PomBaseiSPAC1834.11c. sec18.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • Golgi stack Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845701 – 792Vesicular-fusion protein sec18Add BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Phosphoserine1 Publication1
Modified residuei252Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7Q4.
PRIDEiQ9P7Q4.

PTM databases

iPTMnetiQ9P7Q4.

Interactioni

Protein-protein interaction databases

BioGridi278874. 21 interactors.
MINTiMINT-4706042.

Structurei

3D structure databases

ProteinModelPortaliQ9P7Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000198544.
InParanoidiQ9P7Q4.
KOiK06027.
OMAiFRRAFNS.
OrthoDBiEOG092C0YZZ.
PhylomeDBiQ9P7Q4.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRWKLPFM SNKGTPEQPM RKPLSGSYSH NSAGPTPNMS PFEQKPPLPT
60 70 80 90 100
HMDVRRPSGP FRIVKATSTE DALTNCIIVS PMDFKQQYII VDNSRVFSTK
110 120 130 140 150
PVPGFPQGCL GASQPHREWA SWSLNQQVHV ADYDPYGPHG APYLHSMTLE
160 170 180 190 200
VDFQNRNRTT NEPFDGEEMA KLFCSSYQSQ VFSPGQKIVF DFRSYNIKAT
210 220 230 240 250
VRTISCVDLL IGENQDAENT ADTSKRGLLT SQTEIQFFKA AHSALRLKAS
260 270 280 290 300
MTRPASNAIL QPGFKFEDMG IGGLDSEFSA IFRRAFASRL FPPGMVEKLG
310 320 330 340 350
INHVKGILLY GPPGTGKTLI ARQIGKMLNA REPKIVNGPE ILNKYVGQSE
360 370 380 390 400
ENVRKLFADA EREYRDRGEE SGLHIIIFDE LDAICKKRGS SGGDTGVGDQ
410 420 430 440 450
VVNQLLAKMD GVDQLNNILV IGMTNRKDMI DEALLRPGRL EVHMEISLPD
460 470 480 490 500
EHGRLQILKI HTSRMASNGI LENDVDMEEL ASLTKNFSGA EIAGLIKSAS
510 520 530 540 550
SFAFYRHIKV GTTAAVSGNL ENIKVNRNDF LNALSEVRPA YGVSEEELES
560 570 580 590 600
RVQGGIINFG KHIEEIITEG KLFVQQVKNS ERTRLVSVLL SGPIASGKTA
610 620 630 640 650
LAATIALGSE FPFVKLVSAE SMVGMNENAR VAHVNRVFED SYKSPLSVIV
660 670 680 690 700
VDEIERIIDW VPIGPRFSNT LLQTLMVLFK KQPPKGHRLL ILATTSERTM
710 720 730 740 750
LSRMDMTQSF DAEIAVPNVS NVTELDRIIQ SIDSFADSNV RADTLQRLQN
760 770 780 790
FTGTDAVNVG VAKILMIAET AKQDVDVVSC FVEAMARAIP ME
Length:792
Mass (Da):87,554
Last modified:October 1, 2000 - v1
Checksum:iC983E7ABAC0E80B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB75779.1.
PIRiT50122.
RefSeqiNP_594690.1. NM_001020119.2.

Genome annotation databases

EnsemblFungiiSPAC1834.11c.1; SPAC1834.11c.1:pep; SPAC1834.11c.
GeneIDi2542410.
KEGGispo:SPAC1834.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB75779.1.
PIRiT50122.
RefSeqiNP_594690.1. NM_001020119.2.

3D structure databases

ProteinModelPortaliQ9P7Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278874. 21 interactors.
MINTiMINT-4706042.

PTM databases

iPTMnetiQ9P7Q4.

Proteomic databases

MaxQBiQ9P7Q4.
PRIDEiQ9P7Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1834.11c.1; SPAC1834.11c.1:pep; SPAC1834.11c.
GeneIDi2542410.
KEGGispo:SPAC1834.11c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1834.11c.
PomBaseiSPAC1834.11c. sec18.

Phylogenomic databases

HOGENOMiHOG000198544.
InParanoidiQ9P7Q4.
KOiK06027.
OMAiFRRAFNS.
OrthoDBiEOG092C0YZZ.
PhylomeDBiQ9P7Q4.

Enzyme and pathway databases

ReactomeiR-SPO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-SPO-6807878. COPI-mediated anterograde transport.
R-SPO-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ9P7Q4.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC18_SCHPO
AccessioniPrimary (citable) accession number: Q9P7Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.