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Protein

AP-1 complex subunit sigma-1

Gene

vas2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the AP-1 complex which links clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.1 Publication

GO - Molecular functioni

GO - Biological processi

  • endosomal transport Source: PomBase
  • intracellular protein transport Source: PomBase
  • vesicle-mediated transport Source: PomBase

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit sigma-1
Alternative name(s):
Sigma1-adaptin
Valproic acid-sensitive protein 2
Gene namesi
Name:vas2
Synonyms:aps1
ORF Names:SPAP27G11.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAP27G11.06c
PomBaseiSPAP27G11.06c vas2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Leads to hypersensitivity to valproic acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003162011 – 162AP-1 complex subunit sigma-1Add BLAST162

Proteomic databases

MaxQBiQ9P7N2
PaxDbiQ9P7N2
PRIDEiQ9P7N2

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit apl4 and beta-type subunit apl2), a medium adaptin (mu-type subunit apm1) and a small adaptin (sigma-type subunit aps1). AP-1 interacts with clathrin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4896.SPAP27G11.06c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7N2
SMRiQ9P7N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000185227
OMAiLFFVCGI
OrthoDBiEOG092C59LG
PhylomeDBiQ9P7N2

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKFFLLVS RQGKVRLAKW FNTLSIKERA KIIRDVSSLV ITRKPKMCNF
60 70 80 90 100
VEYKGEKIVY RRYASLFFVC GIEQDDNELI ILEVIHKFVE CLDKYFGNVC
110 120 130 140 150
ELDLIFNFEK AYYVMEELLL AGELQESSKT NVLSAVLAGD AESEADAQQD
160
SLQKLVGSVK KR
Length:162
Mass (Da):18,647
Last modified:October 1, 2000 - v1
Checksum:i9616603E7EF51C7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB76027.1
RefSeqiNP_593410.1, NM_001018843.2

Genome annotation databases

EnsemblFungiiSPAP27G11.06c.1; SPAP27G11.06c.1:pep; SPAP27G11.06c
GeneIDi2542885
KEGGispo:SPAP27G11.06c

Similar proteinsi

Entry informationi

Entry nameiAP1S1_SCHPO
AccessioniPrimary (citable) accession number: Q9P7N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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