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Protein

Ornithine aminotransferase car2

Gene

car2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase car2 (car2)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • arginine catabolic process to glutamate Source: GO_Central
  • arginine catabolic process to proline via ornithine Source: PomBase
  • L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-70614. Amino acid synthesis and interconversion (transamination).
UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase car2 (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:car2
ORF Names:SPBC21C3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21C3.08c.
PomBaseiSPBC21C3.08c. car2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Prevents arginine conversion to other amino acids.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204981 – 438Ornithine aminotransferase car2Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiQ9P7L5.
PRIDEiQ9P7L5.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277152. 11 interactors.
MINTiMINT-4705804.

Structurei

3D structure databases

ProteinModelPortaliQ9P7L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020206.
InParanoidiQ9P7L5.
KOiK00819.
OMAiVKVARKW.
OrthoDBiEOG092C2RJZ.
PhylomeDBiQ9P7L5.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAESLLHNT FSTEQIEVLE NEYAAHNYHP LPVCFSKAKG AKVWDPEGRE
60 70 80 90 100
YLDFLSAYSA VNQGHCHPKI IEALVEQAQR VTLSSRAFYN DKFGPFAKYI
110 120 130 140 150
TEYFGYEMVI PMNTGAEAVE TACKLARLWG YKAKKIPTDE AIILSCVDNF
160 170 180 190 200
HGRTMGIISM STDPDARDNY GPYLPNVGPK ISGADRVLRY NNIEDLKYYL
210 220 230 240 250
DTFGPKVAAF LVEPIQGEAG VMVPDDGYLE EAYKLCKAHN VLFIADEVQT
260 270 280 290 300
GVARTGKMLC IEHSNVKPDV VILGKAISGG VYPVSAVLSS REIMLNFEPG
310 320 330 340 350
THGSTYGGNP LGAAVSIAAL EVVKEEKLTE RAAVLGEKFR TALIECKSPI
360 370 380 390 400
VQKVRGRGLL NAVVIDESKT NGRTAWDLCL IMRSRGVLAK PTHGNIIRFS
410 420 430
PPLVITEEDL MKGIEVIKKS LNDLPTIDMT PYAEKPIH
Length:438
Mass (Da):48,247
Last modified:October 1, 2000 - v1
Checksum:i4D206590E9E4DC22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → S in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti56S → A in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti105G → D in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti118A → T in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti131Y → N in BAA13816 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB76044.1.
D89154 mRNA. Translation: BAA13816.1.
PIRiT42430.
T50352.
RefSeqiNP_596588.1. NM_001022508.2.

Genome annotation databases

EnsemblFungiiSPBC21C3.08c.1; SPBC21C3.08c.1:pep; SPBC21C3.08c.
GeneIDi2540626.
KEGGispo:SPBC21C3.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB76044.1.
D89154 mRNA. Translation: BAA13816.1.
PIRiT42430.
T50352.
RefSeqiNP_596588.1. NM_001022508.2.

3D structure databases

ProteinModelPortaliQ9P7L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277152. 11 interactors.
MINTiMINT-4705804.

Proteomic databases

MaxQBiQ9P7L5.
PRIDEiQ9P7L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC21C3.08c.1; SPBC21C3.08c.1:pep; SPBC21C3.08c.
GeneIDi2540626.
KEGGispo:SPBC21C3.08c.

Organism-specific databases

EuPathDBiFungiDB:SPBC21C3.08c.
PomBaseiSPBC21C3.08c. car2.

Phylogenomic databases

HOGENOMiHOG000020206.
InParanoidiQ9P7L5.
KOiK00819.
OMAiVKVARKW.
OrthoDBiEOG092C2RJZ.
PhylomeDBiQ9P7L5.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.
ReactomeiR-SPO-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiQ9P7L5.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAT_SCHPO
AccessioniPrimary (citable) accession number: Q9P7L5
Secondary accession number(s): P78805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.