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Protein

Ornithine aminotransferase car2

Gene

car2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase car2 (car2)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • arginine catabolic process to proline via ornithine Source: PomBase
  • L-proline biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-70614 Amino acid synthesis and interconversion (transamination)
UniPathwayiUPA00098; UER00358

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase car2 (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:car2
ORF Names:SPBC21C3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21C3.08c
PomBaseiSPBC21C3.08c car2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Prevents arginine conversion to other amino acids.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204981 – 438Ornithine aminotransferase car2Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiQ9P7L5
PaxDbiQ9P7L5
PRIDEiQ9P7L5

PTM databases

iPTMnetiQ9P7L5

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277152, 10 interactors
STRINGi4896.SPBC21C3.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7L5
SMRiQ9P7L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020206
InParanoidiQ9P7L5
KOiK00819
OMAiRTAWDLC
OrthoDBiEOG092C2RJZ
PhylomeDBiQ9P7L5

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR010164 Orn_aminotrans
IPR034758 Orn_aminotrans_mito
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11986:SF18 PTHR11986:SF18, 1 hit
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01885 Orn_aminotrans, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAESLLHNT FSTEQIEVLE NEYAAHNYHP LPVCFSKAKG AKVWDPEGRE
60 70 80 90 100
YLDFLSAYSA VNQGHCHPKI IEALVEQAQR VTLSSRAFYN DKFGPFAKYI
110 120 130 140 150
TEYFGYEMVI PMNTGAEAVE TACKLARLWG YKAKKIPTDE AIILSCVDNF
160 170 180 190 200
HGRTMGIISM STDPDARDNY GPYLPNVGPK ISGADRVLRY NNIEDLKYYL
210 220 230 240 250
DTFGPKVAAF LVEPIQGEAG VMVPDDGYLE EAYKLCKAHN VLFIADEVQT
260 270 280 290 300
GVARTGKMLC IEHSNVKPDV VILGKAISGG VYPVSAVLSS REIMLNFEPG
310 320 330 340 350
THGSTYGGNP LGAAVSIAAL EVVKEEKLTE RAAVLGEKFR TALIECKSPI
360 370 380 390 400
VQKVRGRGLL NAVVIDESKT NGRTAWDLCL IMRSRGVLAK PTHGNIIRFS
410 420 430
PPLVITEEDL MKGIEVIKKS LNDLPTIDMT PYAEKPIH
Length:438
Mass (Da):48,247
Last modified:October 1, 2000 - v1
Checksum:i4D206590E9E4DC22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → S in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti56S → A in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti105G → D in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti118A → T in BAA13816 (PubMed:9501991).Curated1
Sequence conflicti131Y → N in BAA13816 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB76044.1
D89154 mRNA Translation: BAA13816.1
PIRiT42430
T50352
RefSeqiNP_596588.1, NM_001022508.2

Genome annotation databases

EnsemblFungiiSPBC21C3.08c.1; SPBC21C3.08c.1:pep; SPBC21C3.08c
GeneIDi2540626
KEGGispo:SPBC21C3.08c

Similar proteinsi

Entry informationi

Entry nameiOAT_SCHPO
AccessioniPrimary (citable) accession number: Q9P7L5
Secondary accession number(s): P78805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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