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Q9P7I2 (KCC1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calcium/calmodulin-dependent protein kinase type I
Short name=CaMK-I
EC=2.7.11.17
Gene names
Name:cmk1
ORF Names:SPACUNK12.02c, SPAC25D11.02c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Important in cell cycle regulation.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm Ref.1.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Calcium/calmodulin-dependent protein kinase type I
PRO_0000086089

Regions

Domain31 – 291261Protein kinase
Nucleotide binding37 – 459ATP By similarity
Region310 – 33425Calmodulin-binding Potential

Sites

Active site1541Proton acceptor By similarity

Amino acid modifications

Modified residue1921Phosphothreonine; by autocatalysis Ref.1

Experimental info

Mutagenesis1921T → D: 15-fold increase in activity. Ref.1
Sequence conflict1151E → A in AAC26005. Ref.1
Sequence conflict294 – 2952KR → NG in AAC26005. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9P7I2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8761BBCFF6882B02

FASTA33538,164
        10         20         30         40         50         60 
MQQTYKPNTS ALKDGAPKAT VDQKQLLPCK YRVGRVLGGG TYATVREAVH IETNKMYAAK 

        70         80         90        100        110        120 
IMNKKMMEKK QDFVKNEIAI LKRVSYEHPN ILHLVDFFET VNNLYLITEL ATGGELFDRI 

       130        140        150        160        170        180 
CAKGSFYEAD AAALMRTTTS AVKYLHDNGI VHRDLKPENL LYRSKDPNSD LLIADFGLSH 

       190        200        210        220        230        240 
FYEDSQYYML MTACGTPEYM APEVFRRTGY GKPVDMWAIG VITYFLLSGY TPFARPSQVE 

       250        260        270        280        290        300 
VIEAILANEY TFNDPCWSGI SETAKDFIKK CLENDPSKRL TAADALKHPF LSEKRPATSN 

       310        320        330 
LLPNVRENFN ARKTFRTAYN AVRAFNTWKK LENKH

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a calmodulin kinase I homologue from Schizosaccharomyces pombe."
Rasmussen C.D.
J. Biol. Chem. 275:685-690(2000) [PubMed: 10617667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-192, MUTAGENESIS OF THR-192.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF073893 mRNA. Translation: AAC26005.1.
CU329670 Genomic DNA. Translation: CAB76233.1.
PIRT50290.
RefSeqNP_593464.1. NM_001018897.1.

3D structure databases

ProteinModelPortalQ9P7I2.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9P7I2. 2 interactions.
STRINGQ9P7I2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPACUNK12.02c.1; SPACUNK12.02c.1:pep; SPACUNK12.02c.
GeneID2542442.
GenomeReviewsGene locus cmk1 in contig CU329670_GR.
KEGGspo:SPACUNK12.02c.
NMPDRfig|4896.1.peg.3434.

Organism-specific databases

GeneDB_SpombeSPACUNK12.02c.

Phylogenomic databases

eggNOGfuNOG05859.
GeneTreeEFGT00070000008711.
HOGENOMHBG755340.
OMAFTPLEYW.
OrthoDBEOG4G1QRB.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001147-MONOMER.
BRENDA2.7.11.17. 5615.

Gene expression databases

ArrayExpressQ9P7I2.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKCC1_SCHPO
AccessionPrimary (citable) accession number: Q9P7I2
Secondary accession number(s): O74235
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents