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Protein

Serine/threonine-protein phosphatase 2A activator 2

Gene

rrd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg2+ by dissociating the inactive form from the complex (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase PTPA-2
Short name:
PPIase PTPA-2
Short name:
Rotamase PTPA-2
Phosphotyrosyl phosphatase activator 2
Gene namesi
Name:rrd2
ORF Names:SPAC1782.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1782.05.
PomBaseiSPAC1782.05.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Serine/threonine-protein phosphatase 2A activator 2PRO_0000226117Add
BLAST

Proteomic databases

MaxQBiQ9P7H4.

Interactioni

Protein-protein interaction databases

BioGridi278814. 262 interactions.
DIPiDIP-61478N.
MINTiMINT-4705510.

Structurei

3D structure databases

ProteinModelPortaliQ9P7H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.Curated

Phylogenomic databases

HOGENOMiHOG000205736.
InParanoidiQ9P7H4.
KOiK17605.
OMAiMIKMYRA.
OrthoDBiEOG76HQD0.
PhylomeDBiQ9P7H4.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P7H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSREEQNRC FVPVRRILDN EDLKLFKEGD AYKLIDSFIC DLDEAVKDKP
60 70 80 90 100
ISASIPQSSS IEHVLNILDR VGEIKQENPA IDNMGSRFGN PAFQSFYDQV
110 120 130 140 150
YIETPKLHQV FGIEHNAAME AGRYFYESFG NRKRIDYGSG HELYFMSWLL
160 170 180 190 200
ILKQLGIFTK NDYPALVVRV FVKYVELMRS LQIFYTLEPA GSHGVWGLDD
210 220 230 240 250
FHFLPFLFGA AQLVNHKYLR PKHVRDPEIL EMCRADYMYL GYVYFLNKLK
260 270 280 290 300
PSVSLRFHSP MIDDISAVKT WSKVNEGMIK MYRAEVLGKL PIMQHYLFGH
310 320 330 340 350
LIPASPGMSP APQDGDDSEV THVHSHYADC CGIKIPSAIS AAKNNGSRIP

FD
Length:352
Mass (Da):40,288
Last modified:October 1, 2000 - v1
Checksum:iF88B7B260B3DCB90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB76267.1.
PIRiT50095.
RefSeqiNP_594712.1. NM_001020139.2.

Genome annotation databases

EnsemblFungiiSPAC1782.05.1; SPAC1782.05.1:pep; SPAC1782.05.
GeneIDi2542349.
KEGGispo:SPAC1782.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB76267.1.
PIRiT50095.
RefSeqiNP_594712.1. NM_001020139.2.

3D structure databases

ProteinModelPortaliQ9P7H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278814. 262 interactions.
DIPiDIP-61478N.
MINTiMINT-4705510.

Proteomic databases

MaxQBiQ9P7H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1782.05.1; SPAC1782.05.1:pep; SPAC1782.05.
GeneIDi2542349.
KEGGispo:SPAC1782.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC1782.05.
PomBaseiSPAC1782.05.

Phylogenomic databases

HOGENOMiHOG000205736.
InParanoidiQ9P7H4.
KOiK17605.
OMAiMIKMYRA.
OrthoDBiEOG76HQD0.
PhylomeDBiQ9P7H4.

Miscellaneous databases

PROiQ9P7H4.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPTPA2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.