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Protein

H/ACA ribonucleoprotein complex subunit 2

Gene

nhp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Required for stability of the H/ACA snoRNPs.1 Publication

GO - Molecular functioni

  • box H/ACA snoRNA binding Source: PomBase
  • rRNA binding Source: PomBase
  • snoRNA binding Source: UniProtKB

GO - Biological processi

  • cleavage involved in rRNA processing Source: GO_Central
  • maturation of LSU-rRNA Source: GO_Central
  • rRNA pseudouridine synthesis Source: PomBase
  • snRNA pseudouridine synthesis Source: PomBase
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 2
Alternative name(s):
H/ACA snoRNP protein NHP2
High mobility group-like nuclear protein 2
P17-nhp2
Gene namesi
Name:nhp2
ORF Names:SPAC1782.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1782.10c.
PomBaseiSPAC1782.10c. nhp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367751 – 154H/ACA ribonucleoprotein complex subunit 2Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7H0.
PRIDEiQ9P7H0.

PTM databases

iPTMnetiQ9P7H0.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).

Protein-protein interaction databases

BioGridi278833. 9 interactors.
MINTiMINT-4705451.
STRINGi4896.SPAC1782.10c.1.

Structurei

3D structure databases

ProteinModelPortaliQ9P7H0.
SMRiQ9P7H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000055227.
InParanoidiQ9P7H0.
KOiK11129.
OMAiNIPYCYT.
OrthoDBiEOG092C5PRN.
PhylomeDBiQ9P7H0.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiView protein in InterPro
IPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
PfamiView protein in Pfam
PF01248. Ribosomal_L7Ae. 1 hit.
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P7H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDKKDHKH SGSTEDEYDS YLPALMPIAK PLAPKKLNKK MMKTVKKASK
60 70 80 90 100
QKHILRGVKE VVKAVRKGEK GLVILAGDIS PMDVISHIPV LCEDNNVPYL
110 120 130 140 150
YTVSKELLGE ASNTKRPTSC VMIVPGGKKK DMSKVEEYKE SYEEIIKEVP

ALEV
Length:154
Mass (Da):17,178
Last modified:October 1, 2000 - v1
Checksum:i9E5E8FE5E88B6055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76A → P in CAA08990 (PubMed:10502409).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010068 mRNA. Translation: CAA08990.1.
CU329670 Genomic DNA. Translation: CAB76272.1.
PIRiT43644.
T50100.
RefSeqiNP_594717.1. NM_001020144.2.

Genome annotation databases

EnsemblFungiiSPAC1782.10c.1; SPAC1782.10c.1:pep; SPAC1782.10c.
GeneIDi2542369.
KEGGispo:SPAC1782.10c.

Similar proteinsi

Entry informationi

Entry nameiNHP2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7H0
Secondary accession number(s): O94239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2000
Last modified: July 5, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families