Q9P7G9 (KAPS_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase
Short name=APS kinase

Gene names

ORF Names:

SPAC1782.11

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate.
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis Methionine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic process Inferred from mutant phenotype. Source: GeneDB_Spombe sulfate assimilation Inferred by curator. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Adenylyl-sulfate kinase		PRO_0000105933
Regions
	Nucleotide binding	32 – 39	8	ATP By similarity
Sites
	Active site	103	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9P7G9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A5F7E4D53D76353B	FASTA	202	22,669
	10 20 30 40 50 60 MATNITFHPG SVTKEERIKF VGHPGMTIWM TGLSASGKST IACALEQYLL QRGVTTYRLD 70 80 90 100 110 120 GDNVRFGLNS DLGFSEQDRN ENIRRIGHVA KLFADACVVA VTSFISPYRK DRDQAREFHK 130 140 150 160 170 180 KDGLPFIEVY VECPVEVAEQ RDPKGLYKRA RAGEIKEFTG ISAPYEAPIS PEIVVSSHTQ 190 200 SIEECVEKIV NYLLEKDLIT LK

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAB76273.1.
PIR	T50101.
RefSeq	NP_594718.1. NM_001020145.1.
3D structure databases
ProteinModelPortal	Q9P7G9.
SMR	Q9P7G9. Positions 2-202.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9P7G9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC1782.11.1; SPAC1782.11.1:pep; SPAC1782.11.
GeneID	2542359.
KEGG	spo:SPAC1782.11.
NMPDR	fig|4896.1.peg.4688.
Organism-specific databases
GeneDB_Spombe	SPAC1782.11.
Phylogenomic databases
eggNOG	fuNOG05258.
GeneTree	EFGT00050000004141.
HOGENOM	HBG309946.
OMA	RICEIRD.
OrthoDB	EOG48KVMF.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-002798-MONOMER.
Gene expression databases
ArrayExpress	Q9P7G9.
Family and domain databases
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KAPS_SCHPO

Accession

Primary (citable) accession number: Q9P7G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 9, 2003
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program