Reviewed,
UniProtKB/Swiss-Prot Q9P7D7 (LCF2_SCHPO)
Last modified
June 16, 2009.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Long-chain-fatty-acid--CoA ligase 2 EC=6.2.1.3 Alternative name(s): Long-chain acyl-CoA synthetase 2 Fatty acid activator 2 | ||
| Gene names |
| ||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||
| Taxonomic identifier | 4896 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 689 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids By similarity. |
| Catalytic activity | ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. |
| Cofactor | Magnesium By similarity. |
| Subcellular location | Golgi apparatus. Vacuole membrane; Peripheral membrane protein. Ref.2 |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism |
| Cellular component | Golgi apparatus Membrane Vacuole |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | long-chain fatty acid metabolic process Inferred from genetic interaction. Source: GeneDB_SPombe |
| Cellular component | Golgi apparatus Ref.2 Inferred from direct assay. Source: GeneDB_SPombe vacuolar membrane Ref.2Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain-fatty-acid-CoA ligase activityInferred from genetic interaction. Source: GeneDB_SPombe |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 689 | 689 | Long-chain-fatty-acid--CoA ligase 2 | PRO_0000311761 | |||
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| CU329671 Genomic DNA. Translation: CAB83169.1. | |
| RefSeq | NP_596185.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LCI based on UniProtKB P08659. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9P7D7. 1 interaction. |
Genome annotation databases | |
| GeneID | 2541350. |
| KEGG | spo:SPBP4H10.11c. |
| NMPDR | fig|4896.1.peg.2051. |
Organism-specific databases | |
| GeneDB_Spombe | SPBP4H10.11c. |
Phylogenomic databases | |
| OMA | Q9P7D7. NESINRE. |
Enzyme and pathway databases | |
| BRENDA | 6.2.1.3. 653. |
Gene expression databases | |
| ArrayExpress | Q9P7D7. |
Family and domain databases | |
| InterPro | IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| Pfam | PF00501. AMP-binding. 2 hits. [Graphical view] |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LCF2_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q9P7D7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


