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Q9P7D7

- LCF2_SCHPO

UniProt

Q9P7D7 - LCF2_SCHPO

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Protein

Long-chain-fatty-acid--CoA ligase 2

Gene

lcf2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Plays an important role in the determination of viability in the stationary phase.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. myristoyl-CoA ligase activity Source: PomBase

GO - Biological processi

  1. long-chain fatty acid metabolic process Source: PomBase
  2. N-terminal protein myristoylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 2 (EC:6.2.1.3)
Alternative name(s):
Fatty acid activator 2
Long-chain acyl-CoA synthetase 2
Gene namesi
Name:lcf2
ORF Names:SPBP4H10.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBP4H10.11c.

Subcellular locationi

Golgi apparatus 1 Publication. Vacuole membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. fungal-type vacuole membrane Source: PomBase
  3. Golgi apparatus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Long-chain-fatty-acid--CoA ligase 2PRO_0000311761Add
BLAST

Proteomic databases

MaxQBiQ9P7D7.

Interactioni

Protein-protein interaction databases

BioGridi277861. 8 interactions.
IntActiQ9P7D7. 1 interaction.
MINTiMINT-4705249.
STRINGi4896.SPBP4H10.11c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P7D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000159459.
InParanoidiQ9P7D7.
KOiK01897.
OMAiFLVENIC.
OrthoDBiEOG7CCC0K.
PhylomeDBiQ9P7D7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7D7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIKDYYCVE TKDSKQPGES YIYRSIHSAG KLLDTPEDGV STVYDLLCTA
60 70 80 90 100
AKNHGEKQAM GSRKLIKENR EEREIIRKVD NEEVVEKKLW TTYELGPYEY
110 120 130 140 150
ISFNKVYEIA LALGSGLVAS GITSETTMLF FAATSAKWFT TAQGCSSQAI
160 170 180 190 200
PIVTAYETLG EDGIYTSLDE CKSRAIFTDP NLIPKLLGPL KQSTWVKLIV
210 220 230 240 250
CSSTPSEDLV ELVKSTAPDV EIITYDNLLS LGKEKPQPPH PPKADDICCY
260 270 280 290 300
MYTSGSTGKP KGVVLLHRNI IAALGGINRI LSQHINVKDY VLAYLPLAHI
310 320 330 340 350
FEFIFEMCCL YWGGVLGYAS PRTLTDASVV NCKGDLTEFR PTVLIGVPAV
360 370 380 390 400
YELIKKGILA KVSSMPAHRQ KVFSGSLSLK QYLIERNLPG SAALDAIVFN
410 420 430 440 450
KVKAATGGRL RYCISGGAAL AASTQAFLSS CICPVLPGYG LTETCAGSFV
460 470 480 490 500
LSPEQWHLYA NTVGFPIPSI EFKLVDIPDL GYYTDSSPPR GEVWIRGPAV
510 520 530 540 550
CNGYLNRPED NKAAFTEDGW FKTGDVGEIA KGNTLRLIDR KKNIVKSLNG
560 570 580 590 600
EYIALEKIEA QFFTSPLVSN VCAYADVNHA KPVVIVNPDE NGLRTYLTKN
610 620 630 640 650
SGSSFNGNPN DTLTNLCKDS GVQHLILKEL INIGKQQRLA SIEIPEGVVL
660 670 680
SDFEWTAENN FLTASRKVKR QVIVAHYSDE IQKAYSKKH
Length:689
Mass (Da):75,791
Last modified:October 1, 2000 - v1
Checksum:i5F80C06F6EA92F87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB83169.1.
RefSeqiNP_596185.1. NM_001022104.2.

Genome annotation databases

EnsemblFungiiSPBP4H10.11c.1; SPBP4H10.11c.1:pep; SPBP4H10.11c.
GeneIDi2541350.
KEGGispo:SPBP4H10.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB83169.1 .
RefSeqi NP_596185.1. NM_001022104.2.

3D structure databases

ProteinModelPortali Q9P7D7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277861. 8 interactions.
IntActi Q9P7D7. 1 interaction.
MINTi MINT-4705249.
STRINGi 4896.SPBP4H10.11c-1.

Proteomic databases

MaxQBi Q9P7D7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBP4H10.11c.1 ; SPBP4H10.11c.1:pep ; SPBP4H10.11c .
GeneIDi 2541350.
KEGGi spo:SPBP4H10.11c.

Organism-specific databases

PomBasei SPBP4H10.11c.

Phylogenomic databases

eggNOGi COG1022.
HOGENOMi HOG000159459.
InParanoidi Q9P7D7.
KOi K01897.
OMAi FLVENIC.
OrthoDBi EOG7CCC0K.
PhylomeDBi Q9P7D7.

Miscellaneous databases

NextBioi 20802459.
PROi Q9P7D7.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. "Identification of a fatty acyl-CoA synthetase gene, lcf2+, which affects viability after entry into the stationary phase in Schizosaccharomyces pombe."
    Fujita Y., Mita S., Ohtsuka H., Aiba H.
    Biosci. Biotechnol. Biochem. 71:3041-3047(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLCF2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3