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Protein

Long-chain-fatty-acid--CoA ligase 2

Gene

lcf2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Plays an important role in the determination of viability in the stationary phase.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • decanoate-CoA ligase activity Source: UniProtKB-EC
  • myristoyl-CoA ligase activity Source: PomBase

GO - Biological processi

  • long-chain fatty-acyl-CoA metabolic process Source: PomBase
  • N-terminal protein myristoylation Source: PomBase

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 2 (EC:6.2.1.3)
Alternative name(s):
Fatty acid activator 2
Long-chain acyl-CoA synthetase 2
Gene namesi
Name:lcf2
ORF Names:SPBP4H10.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP4H10.11c
PomBaseiSPBP4H10.11c lcf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003117611 – 689Long-chain-fatty-acid--CoA ligase 2Add BLAST689

Proteomic databases

MaxQBiQ9P7D7
PaxDbiQ9P7D7
PRIDEiQ9P7D7

PTM databases

iPTMnetiQ9P7D7

Interactioni

Protein-protein interaction databases

BioGridi277861, 5 interactors
IntActiQ9P7D7, 1 interactor
MINTiQ9P7D7
STRINGi4896.SPBP4H10.11c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7D7
SMRiQ9P7D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000159459
InParanoidiQ9P7D7
KOiK01897
OMAiHIMEFTI
OrthoDBiEOG092C0RYI
PhylomeDBiQ9P7D7

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKDYYCVE TKDSKQPGES YIYRSIHSAG KLLDTPEDGV STVYDLLCTA
60 70 80 90 100
AKNHGEKQAM GSRKLIKENR EEREIIRKVD NEEVVEKKLW TTYELGPYEY
110 120 130 140 150
ISFNKVYEIA LALGSGLVAS GITSETTMLF FAATSAKWFT TAQGCSSQAI
160 170 180 190 200
PIVTAYETLG EDGIYTSLDE CKSRAIFTDP NLIPKLLGPL KQSTWVKLIV
210 220 230 240 250
CSSTPSEDLV ELVKSTAPDV EIITYDNLLS LGKEKPQPPH PPKADDICCY
260 270 280 290 300
MYTSGSTGKP KGVVLLHRNI IAALGGINRI LSQHINVKDY VLAYLPLAHI
310 320 330 340 350
FEFIFEMCCL YWGGVLGYAS PRTLTDASVV NCKGDLTEFR PTVLIGVPAV
360 370 380 390 400
YELIKKGILA KVSSMPAHRQ KVFSGSLSLK QYLIERNLPG SAALDAIVFN
410 420 430 440 450
KVKAATGGRL RYCISGGAAL AASTQAFLSS CICPVLPGYG LTETCAGSFV
460 470 480 490 500
LSPEQWHLYA NTVGFPIPSI EFKLVDIPDL GYYTDSSPPR GEVWIRGPAV
510 520 530 540 550
CNGYLNRPED NKAAFTEDGW FKTGDVGEIA KGNTLRLIDR KKNIVKSLNG
560 570 580 590 600
EYIALEKIEA QFFTSPLVSN VCAYADVNHA KPVVIVNPDE NGLRTYLTKN
610 620 630 640 650
SGSSFNGNPN DTLTNLCKDS GVQHLILKEL INIGKQQRLA SIEIPEGVVL
660 670 680
SDFEWTAENN FLTASRKVKR QVIVAHYSDE IQKAYSKKH
Length:689
Mass (Da):75,791
Last modified:October 1, 2000 - v1
Checksum:i5F80C06F6EA92F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB83169.1
RefSeqiNP_596185.1, NM_001022104.2

Genome annotation databases

EnsemblFungiiSPBP4H10.11c.1; SPBP4H10.11c.1:pep; SPBP4H10.11c
GeneIDi2541350
KEGGispo:SPBP4H10.11c

Similar proteinsi

Entry informationi

Entry nameiLCF2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health