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Q9P7D4 (ACON2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable aconitate hydratase 2
Short name=Aconitase
EC=4.2.1.3
Alternative name(s):
Citrate hydro-lyase
Gene names
ORF Names:SPBP4H10.15
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity.

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subcellular location

Mitochondrion Ref.2.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 912912Probable aconitate hydratase 2
PRO_0000316198

Regions

Region192 – 1943Substrate binding By similarity
Region674 – 6752Substrate binding By similarity

Sites

Metal binding3881Iron-sulfur (4Fe-4S) By similarity
Metal binding4511Iron-sulfur (4Fe-4S) By similarity
Metal binding4541Iron-sulfur (4Fe-4S) By similarity
Binding site991Substrate By similarity
Binding site4781Substrate By similarity
Binding site4831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9P7D4 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 39437932E866FA2F

FASTA91299,224
        10         20         30         40         50         60 
MKLCLSGSSQ AIPSKGISLV AARFQSTASR ASYVTPPYEK LMGKLQQVRK FLPGQKLTLA 

        70         80         90        100        110        120 
EKVLYSHLVN PEESFSGVSP SDIRGSLYLK LNPDRVAMQD ASAQMALLQF MTCGLEKTMI 

       130        140        150        160        170        180 
PASIHCDHLI VGHRGANSDI PDSIANNKEI FDFLQSAAKK YGIQFWGPGS GIIHQIVLEN 

       190        200        210        220        230        240 
YAAPGGMMLG TDSHTPNAGG LGMIAIGVGG ADAVDAMTNT PWELKAPKII GVNLTGAMSG 

       250        260        270        280        290        300 
WTTPKDLILH LAGKLTVRGG TGHIIEYFGP GVASLSCTGM ATVCNMGAEV GATTSIFPYT 

       310        320        330        340        350        360 
DSMRRYLIAT HRAEVADAAS EVHSEYNYLA ADTGAKYDQI IDINLSELTP SLNGPFTPDL 

       370        380        390        400        410        420 
STPVSKFGEA IEKNKWPKKL SAGLIGSCTN SSYQDMTCVV DVVEQAISAG LKPKVPFLVT 

       430        440        450        460        470        480 
PGSEQIRATI ERDGITERLE EAGATVLANA CGPCIGMWKR TDDIASGEPN AILTSFNRNF 

       490        500        510        520        530        540 
RSRNDGNPST MNFLTSPVIV AAKIFSSDLA FDPTHDTLQT PDGKAFKFRP PQGVELPSAG 

       550        560        570        580        590        600 
FIAGDSSYIP EPNPQPVPET EVTIDPKSDR LEALEPFEPY QGGEMENLKV AVKVKGKCTT 

       610        620        630        640        650        660 
DHISAAGKWL KYKGHLSNIC NNTLIGAMNA ATGEVNRAYD NGKGMTIPEL MWKWKKDGQP 

       670        680        690        700        710        720 
WLVVAEHNYG EGSAREHAAL QPRAMNGRII LTKSFARIHE TNLKKQGVLP LTFVNEADYE 

       730        740        750        760        770        780 
KIDAEDKVST RGIEQLLEGV LDQPITLVVT KKDGSVVEIP CKHTMSKDQI EFFKAGSALN 

       790        800        810        820        830        840 
LIREKAHSGV VNQKVIDSIK QQPDHYADAY IFNRHFVIAK GDQLGLPFHL KGVQVGDTIR 

       850        860        870        880        890        900 
LDKIASFGSR DFTLFGNPYV DPSLFTIEAV VLSFPKSALS VRVKHKRRHR HDRVMKHKQT 

       910 
YTILRVTELK LN

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB83173.2.
RefSeqNP_596189.2. NM_001022108.2.

3D structure databases

HSSPHSSP built from PDB template 1AMJ based on UniProtKB P20004.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9P7D4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2541348.
KEGGspo:SPBP4H10.15.
NMPDRfig|4896.1.peg.2055.

Organism-specific databases

GeneDB_SpombeSPBP4H10.15.

Phylogenomic databases

eggNOGfuNOG07522.
GeneTreeEFGT00050000001032.
HOGENOMHBG295973.
OMAQVEFFKA.
OrthoDBEOG47M561.

Gene expression databases

ArrayExpressQ9P7D4.

Family and domain databases

InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR006248. Aconitase_mito-like.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR001787. Ribosomal_L21.
[Graphical view]
Gene3DG3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits.
G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit.
G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
KOK01681.
PANTHERPTHR11670. Aconitase-like_core. 1 hit.
PTHR11670:SF5. Aconitase_mito. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
PF00829. Ribosomal_L21p. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
SSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01340. Aconitase_mito. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON2_SCHPO
AccessionPrimary (citable) accession number: Q9P7D4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: December 14, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents