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Q9P7D4

- ACON2_SCHPO

UniProt

Q9P7D4 - ACON2_SCHPO

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Protein
Homocitrate dehydratase, mitochondrial
Gene
SPBP4H10.15
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis By similarity.

Catalytic activityi

(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O.

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051Substrate By similarity
Metal bindingi394 – 3941Iron-sulfur (4Fe-4S) By similarity
Metal bindingi457 – 4571Iron-sulfur (4Fe-4S) By similarity
Metal bindingi460 – 4601Iron-sulfur (4Fe-4S) By similarity
Binding sitei484 – 4841Substrate By similarity
Binding sitei489 – 4891Substrate By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. aconitate hydratase activity Source: PomBase
  3. metal ion binding Source: UniProtKB-KW
  4. structural constituent of ribosome Source: PomBase

GO - Biological processi

  1. glutamate metabolic process Source: PomBase
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
  3. mitochondrial translation Source: PomBase
  4. tricarboxylic acid cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00033; UER00029.

Names & Taxonomyi

Protein namesi
Recommended name:
Homocitrate dehydratase, mitochondrial (EC:4.2.1.-)
Alternative name(s):
Aconitase 2
Gene namesi
ORF Names:SPBP4H10.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBP4H10.15.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030Mitochondrion Reviewed prediction
Add
BLAST
Chaini31 – 918888Homocitrate dehydratase, mitochondrial
PRO_0000316198Add
BLAST

Proteomic databases

MaxQBiQ9P7D4.
PaxDbiQ9P7D4.

Interactioni

Protein-protein interaction databases

BioGridi277859. 5 interactions.
MINTiMINT-4705221.
STRINGi4896.SPBP4H10.15-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P7D4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 2003Substrate binding By similarity
Regioni680 – 6812Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1048.
HOGENOMiHOG000224293.
KOiK17450.
OrthoDBiEOG7X6M7Q.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR006248. Aconitase_mito-like.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR028909. L21p-like.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
PF00829. Ribosomal_L21p. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF141091. SSF141091. 1 hit.
SSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01340. aconitase_mito. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P7D4-1 [UniParc]FASTAAdd to Basket

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MATFARMKLC LSGSSQAIPS KGISLVAARF QSTASRASYV TPPYEKLMGK    50
LQQVRKFLPG QKLTLAEKVL YSHLVNPEES FSGVSPSDIR GSLYLKLNPD 100
RVAMQDASAQ MALLQFMTCG LEKTMIPASI HCDHLIVGHR GANSDIPDSI 150
ANNKEIFDFL QSAAKKYGIQ FWGPGSGIIH QIVLENYAAP GGMMLGTDSH 200
TPNAGGLGMI AIGVGGADAV DAMTNTPWEL KAPKIIGVNL TGAMSGWTTP 250
KDLILHLAGK LTVRGGTGHI IEYFGPGVAS LSCTGMATVC NMGAEVGATT 300
SIFPYTDSMR RYLIATHRAE VADAASEVHS EYNYLAADTG AKYDQIIDIN 350
LSELTPSLNG PFTPDLSTPV SKFGEAIEKN KWPKKLSAGL IGSCTNSSYQ 400
DMTCVVDVVE QAISAGLKPK VPFLVTPGSE QIRATIERDG ITERLEEAGA 450
TVLANACGPC IGMWKRTDDI ASGEPNAILT SFNRNFRSRN DGNPSTMNFL 500
TSPVIVAAKI FSSDLAFDPT HDTLQTPDGK AFKFRPPQGV ELPSAGFIAG 550
DSSYIPEPNP QPVPETEVTI DPKSDRLEAL EPFEPYQGGE MENLKVAVKV 600
KGKCTTDHIS AAGKWLKYKG HLSNICNNTL IGAMNAATGE VNRAYDNGKG 650
MTIPELMWKW KKDGQPWLVV AEHNYGEGSA REHAALQPRA MNGRIILTKS 700
FARIHETNLK KQGVLPLTFV NEADYEKIDA EDKVSTRGIE QLLEGVLDQP 750
ITLVVTKKDG SVVEIPCKHT MSKDQIEFFK AGSALNLIRE KAHSGVVNQK 800
VIDSIKQQPD HYADAYIFNR HFVIAKGDQL GLPFHLKGVQ VGDTIRLDKI 850
ASFGSRDFTL FGNPYVDPSL FTIEAVVLSF PKSALSVRVK HKRRHRHDRV 900
MKHKQTYTIL RVTELKLN 918
Length:918
Mass (Da):99,901
Last modified:July 11, 2012 - v3
Checksum:iA17A3132B7B21D90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB83173.3.
RefSeqiNP_596189.3. NM_001022108.3.

Genome annotation databases

EnsemblFungiiSPBP4H10.15.1; SPBP4H10.15.1:pep; SPBP4H10.15.
GeneIDi2541348.
KEGGispo:SPBP4H10.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB83173.3 .
RefSeqi NP_596189.3. NM_001022108.3.

3D structure databases

ProteinModelPortali Q9P7D4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277859. 5 interactions.
MINTi MINT-4705221.
STRINGi 4896.SPBP4H10.15-1.

Proteomic databases

MaxQBi Q9P7D4.
PaxDbi Q9P7D4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBP4H10.15.1 ; SPBP4H10.15.1:pep ; SPBP4H10.15 .
GeneIDi 2541348.
KEGGi spo:SPBP4H10.15.

Organism-specific databases

PomBasei SPBP4H10.15.

Phylogenomic databases

eggNOGi COG1048.
HOGENOMi HOG000224293.
KOi K17450.
OrthoDBi EOG7X6M7Q.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00029 .

Miscellaneous databases

NextBioi 20802457.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR006248. Aconitase_mito-like.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR028909. L21p-like.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
PF00829. Ribosomal_L21p. 1 hit.
[Graphical view ]
PRINTSi PR00415. ACONITASE.
SUPFAMi SSF141091. SSF141091. 1 hit.
SSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsi TIGR01340. aconitase_mito. 1 hit.
PROSITEi PS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACON2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 11, 2012
Last modified: September 3, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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