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Protein

DNA replication complex GINS protein sld5

Gene

sld5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation and is required for bir1 localization.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chromosome partition, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein sld5
Gene namesi
Name:sld5
ORF Names:SPBP4H10.21c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP4H10.21c.
PomBaseiSPBP4H10.21c. sld5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • DNA replication preinitiation complex Source: PomBase
  • GINS complex Source: GO_Central
  • nucleus Source: PomBase
  • replication fork protection complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214DNA replication complex GINS protein sld5PRO_0000255434Add
BLAST

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of sld5, psf1, psf2 and psf3. Interacts with sld5.1 Publication

Protein-protein interaction databases

BioGridi277879. 5 interactions.
IntActiQ9P7C8. 1 interaction.
MINTiMINT-4705166.

Structurei

3D structure databases

ProteinModelPortaliQ9P7C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS4/SLD5 family.Curated

Phylogenomic databases

HOGENOMiHOG000215319.
InParanoidiQ9P7C8.
KOiK10735.
OMAiFRIMLAQ.
OrthoDBiEOG7KDFPN.
PhylomeDBiQ9P7C8.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR008591. GINS_Sld5.
IPR031633. SLD5_C.
[Graphical view]
PANTHERiPTHR21206. PTHR21206. 1 hit.
PfamiPF05916. Sld5. 1 hit.
PF16922. SLD5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF007764. Sld5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P7C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWDADDLLI EPTTEVENDY EDLCTQWVNE RMAPDLLPFA EEIVSRVLDR
60 70 80 90 100
IEAQRETLQL AIGTSSATSY RSVLMQTELE RVKFVLRSYM RTRINKIDKY
110 120 130 140 150
AQYIQSHPNL LLYLSSPERQ YLLRHQQIVH RHYMDSFLRE VPAKMNKLDD
160 170 180 190 200
KVGNLSMVAS PDMDTAVFCV VNESVEENFR VSENEYITLD KGDVLILRYS
210
VISDYLRLGV VSLI
Length:214
Mass (Da):24,989
Last modified:October 1, 2000 - v1
Checksum:i9B1C7E50A471891F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB83179.1.
RefSeqiNP_596195.1. NM_001022114.2.

Genome annotation databases

EnsemblFungiiSPBP4H10.21c.1; SPBP4H10.21c.1:pep; SPBP4H10.21c.
GeneIDi2541368.
KEGGispo:SPBP4H10.21c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB83179.1.
RefSeqiNP_596195.1. NM_001022114.2.

3D structure databases

ProteinModelPortaliQ9P7C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277879. 5 interactions.
IntActiQ9P7C8. 1 interaction.
MINTiMINT-4705166.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP4H10.21c.1; SPBP4H10.21c.1:pep; SPBP4H10.21c.
GeneIDi2541368.
KEGGispo:SPBP4H10.21c.

Organism-specific databases

EuPathDBiFungiDB:SPBP4H10.21c.
PomBaseiSPBP4H10.21c. sld5.

Phylogenomic databases

HOGENOMiHOG000215319.
InParanoidiQ9P7C8.
KOiK10735.
OMAiFRIMLAQ.
OrthoDBiEOG7KDFPN.
PhylomeDBiQ9P7C8.

Miscellaneous databases

PROiQ9P7C8.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR008591. GINS_Sld5.
IPR031633. SLD5_C.
[Graphical view]
PANTHERiPTHR21206. PTHR21206. 1 hit.
PfamiPF05916. Sld5. 1 hit.
PF16922. SLD5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF007764. Sld5. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation."
    Huang H.-K., Bailis J.M., Leverson J.D., Gomez E.B., Forsburg S.L., Hunter T.
    Mol. Cell. Biol. 25:9000-9015(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PSF2.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSLD5_SCHPO
AccessioniPrimary (citable) accession number: Q9P7C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.