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Protein

Pre-mRNA-splicing factor cwf23

Gene

cwf23

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor cwf23
Alternative name(s):
Complexed with cdc5 protein 23
Gene namesi
Name:cwf23
ORF Names:SPCC10H11.02, SPCP31B10.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC10H11.02.
PomBaseiSPCC10H11.02. cwf23.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
  • spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000711281 – 289Pre-mRNA-splicing factor cwf23Add BLAST289

Proteomic databases

MaxQBiQ9P7C6.
PRIDEiQ9P7C6.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Protein-protein interaction databases

BioGridi275838. 5 interactors.
IntActiQ9P7C6. 1 interactor.
MINTiMINT-4705134.

Structurei

3D structure databases

ProteinModelPortaliQ9P7C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 74JPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the DnaJ family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ9P7C6.
KOiK09537.
OMAiELDCALK.
OrthoDBiEOG092C4VHO.
PhylomeDBiQ9P7C6.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P7C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEGDSIDY YELLGINEDA QDQEIHRAWR KTSLKYHPDK NPNDPKAAEK
60 70 80 90 100
FHMLQLAYNA LIDVQLRKAY DSERFAKLAR KRREEAFNFQ RKSMVDDLRE
110 120 130 140 150
RERQFYDSLE KKENERDRLQ EKLRALQEES ANLRRQRENR LREEQEQSKR
160 170 180 190 200
RKQETPSSKI SELDRSIRIR WKRKYADQVN DAYLRSIYSS FGTLQNVVIQ
210 220 230 240 250
KDISKEKKYV YSIIVFETLS SAYSAINAEK PSKIYDVQWL KPPKSNSNTP
260 270 280
TEKDTTVEDY EEITIMRMKQ KHKQKQKENE RKATSTMNA
Length:289
Mass (Da):34,575
Last modified:March 5, 2002 - v2
Checksum:iF3E85FAF6BBF2041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB85447.1.
PIRiT41691.
RefSeqiNP_587857.2. NM_001022850.2.

Genome annotation databases

EnsemblFungiiSPCC10H11.02.1; SPCC10H11.02.1:pep; SPCC10H11.02.
GeneIDi2539268.
KEGGispo:SPCC10H11.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB85447.1.
PIRiT41691.
RefSeqiNP_587857.2. NM_001022850.2.

3D structure databases

ProteinModelPortaliQ9P7C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275838. 5 interactors.
IntActiQ9P7C6. 1 interactor.
MINTiMINT-4705134.

Proteomic databases

MaxQBiQ9P7C6.
PRIDEiQ9P7C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC10H11.02.1; SPCC10H11.02.1:pep; SPCC10H11.02.
GeneIDi2539268.
KEGGispo:SPCC10H11.02.

Organism-specific databases

EuPathDBiFungiDB:SPCC10H11.02.
PomBaseiSPCC10H11.02. cwf23.

Phylogenomic databases

InParanoidiQ9P7C6.
KOiK09537.
OMAiELDCALK.
OrthoDBiEOG092C4VHO.
PhylomeDBiQ9P7C6.

Miscellaneous databases

PROiQ9P7C6.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCWC23_SCHPO
AccessioniPrimary (citable) accession number: Q9P7C6
Secondary accession number(s): Q9USH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: October 5, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.