Reviewed,
UniProtKB/Swiss-Prot Q9P7C3 (YKU1_SCHPO)
Last modified
January 19, 2010.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative mannosyl-oligosaccharide 1,2-alpha-mannosidase EC=3.2.1.113 Alternative name(s): Man(9)-alpha-mannosidase | ||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||
| Taxonomic identifier | 4896 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 521 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2. |
| Cofactor | Calcium By similarity. |
| Pathway | |
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the glycosyl hydrolase 47 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane |
| Ligand | Calcium |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum membrane Inferred by curator. Source: GeneDB_SPombe integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW mannosyl-oligosaccharide 1,2-alpha-mannosidase activityInferred from mutant phenotype. Source: GeneDB_SPombe |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 521 | 521 | Putative mannosyl-oligosaccharide 1,2-alpha-mannosidase | PRO_0000210320 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 8 | 8 | Cytoplasmic Potential | ||||||||
| Transmembrane | 9 – 31 | 23 | Signal-anchor for type II membrane protein Potential | ||||||||
| Topological domain | 32 – 521 | 490 | Lumenal Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 114 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 167 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 300 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 342 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 378 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 499 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 330 ↔ 373 | By similarity | |||||||||
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329670 Genomic DNA. Translation: CAC36930.1. |
| RefSeq | NP_594139.2. |
3D structure databases | |
| SMR | Q9P7C3. Positions 42-516. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9P7C3. |
Protein family/group databases | |
| CAZy | GH47. Glycoside Hydrolase Family 47. |
Genome annotation databases | |
| GeneID | 2541719. |
| KEGG | spo:SPAC2E1P5.01c. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC2E1P5.01c. |
Phylogenomic databases | |
| eggNOG | fuNOG05524. |
| HOGENOM | HBG559734. |
| OrthoDB | EOG9DFR4W. |
| PhylomeDB | Q9P7C3. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.113. 653. |
Gene expression databases | |
| ArrayExpress | Q9P7C3. |
Family and domain databases | |
| InterPro | IPR001382. Glyco_hydro_47. [Graphical view] |
| Gene3D | G3DSA:1.50.10.50. Glyco_hydro_47. 1 hit. |
| PANTHER | PTHR11742. Glyco_hydro_47. 1 hit. |
| Pfam | PF01532. Glyco_hydro_47. 1 hit. [Graphical view] |
| PRINTS | PR00747. GLYHDRLASE47. |
| ProtoNet | Search... |
Entry information
| Entry name | YKU1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q9P7C3 Secondary accession number(s): Q9C0Z6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


