Reviewed, UniProtKB/Swiss-Prot Q9P795 (AIR1_SCHPO)

Names and origin

Protein names

Recommended name:
    Protein air1

Gene names

Name:	air1
ORF Names:	SPBP35G2.08c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. Ref.2
Subunit structure	Component of the TRAMP complex (also called TRF4 complex) composed of at least mtr4, pap2/trf4 and air1. Component of the TRAMP5 complex composed of at least air1, mtr4 and trf5. Interacts with cid14. Ref.2
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the AIR1 family. Contains 3 CCHC-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	TRAMP complex Ref.2 Inferred from direct assay. Source: GeneDB_SPombe nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Protein air1		PRO_0000356248
Regions
	Zinc finger	87 – 104	18	CCHC-type 1
	Zinc finger	125 – 142	18	CCHC-type 2
	Zinc finger	187 – 204	18	CCHC-type 3
Amino acid modifications
	Modified residue	10	1	Phosphoserine Ref.3
	Modified residue	14	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9P795-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 90BDF9596AE48D2A	FASTA	313	35,299
	10 20 30 40 50 60 MTVSNQKAES DDGSDIDDAA LLQKINSLPI DQSITNSVSL EKHDFQGSDD HDSSTDLSDS 70 80 90 100 110 120 TLEDVEGSEW ADVSRGRYFG SDPSESIVCH NCKGNGHISK DCPHVLCTTC GAIDDHISVR 130 140 150 160 170 180 CPWTKKCMNC GLLGHIAARC SEPRKRGPRV CRTCHTDTHT SSTCPLIWRY YVEKEHPVRI 190 200 210 220 230 240 DVSEVRKFCY NCASDEHFGD DCTLPSRSNY PESTAFCEAN CPSGNDASNK EFFETRRKEF 250 260 270 280 290 300 QLERREQNRN QKSSKQRPFH KPGNSLASRL GSKPKSFKRK HSPPSEENGN LSFHSSDGRK 310 FTKTSKKNRK RKW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing." Buehler M., Haas W., Gygi S.P., Moazed D. Cell 129:707-721(2007) [PubMed: 17512405] [Abstract] Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CID14.
[3]	"Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-14, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329671 Genomic DNA. Translation: CAB87370.1.
RefSeq	NP_595383.1.
3D structure databases
HSSP	HSSP built from PDB template 2CQF based on UniProtKB Q9H9Z2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9P795.
Genome annotation databases
GeneID	2541349.
GenomeReviews	Gene locus air1 in contig CU329671_GR.
KEGG	spo:SPBP35G2.08c.
NMPDR	fig|4896.1.peg.1249.
Organism-specific databases
GeneDB_Spombe	SPBP35G2.08c.
Phylogenomic databases
OMA	RICARCY
OrthoDB	EOG93FJCZ
Gene expression databases
ArrayExpress	Q9P795.
Family and domain databases
InterPro	IPR016713. PolA_Pol_cplx_Air1/2_su. IPR001878. Znf_CCHC. [Graphical view]
Pfam	PF00098. zf-CCHC. 2 hits. [Graphical view]
PIRSF	PIRSF018162. PolyA_pol_Air1/2. 1 hit.
SMART	SM00343. ZnF_C2HC. 5 hits. [Graphical view]
PROSITE	PS50158. ZF_CCHC. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AIR1_SCHPO

Accession

Primary (citable) accession number: Q9P795

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)