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Protein

Chromatin remodeling factor mit1

Gene

mit1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 271PHD-typePROSITE-ProRule annotationAdd BLAST60
Zinc fingeri215 – 269RING-type; atypicalAdd BLAST55
Nucleotide bindingi581 – 588ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: PomBase
  • ATP binding Source: PomBase
  • helicase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at rDNA Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • nucleosome positioning Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin remodeling factor mit1 (EC:3.6.4.-)
Alternative name(s):
Mi2-like interacting with clr3 protein 1
Snf2/Hdac-containing repressor complex protein mit1
Short name:
SHREC protein mit1
Gene namesi
Name:mit1
ORF Names:SPBP35G2.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP35G2.10.
PomBaseiSPBP35G2.10. mit1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: UniProtKB-SubCell
  • mating-type region heterochromatin Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nuclear pericentric heterochromatin Source: PomBase
  • nuclear subtelomeric heterochromatin Source: PomBase
  • nucleus Source: PomBase
  • rDNA heterochromatin Source: PomBase
  • SHREC complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus, Telomere

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi587K → A: Weak silencing defect. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003394201 – 1418Chromatin remodeling factor mit1Add BLAST1418

Proteomic databases

PRIDEiQ9P793.

Interactioni

Subunit structurei

Interacts with clr3.1 Publication

Protein-protein interaction databases

BioGridi277847. 24 interactors.
MINTiMINT-4704956.

Structurei

Secondary structure

11418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1223 – 1230Combined sources8
Helixi1241 – 1253Combined sources13
Beta strandi1286 – 1289Combined sources4
Helixi1293 – 1301Combined sources9
Beta strandi1306 – 1308Combined sources3
Turni1312 – 1314Combined sources3
Helixi1324 – 1326Combined sources3
Beta strandi1330 – 1332Combined sources3
Turni1334 – 1336Combined sources3
Beta strandi1337 – 1339Combined sources3
Beta strandi1342 – 1345Combined sources4
Helixi1348 – 1350Combined sources3
Helixi1353 – 1364Combined sources12
Helixi1370 – 1381Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IKFX-ray2.80A1156-1417[»]
ProteinModelPortaliQ9P793.
SMRiQ9P793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini568 – 738Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini875 – 1034Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 271PHD-typePROSITE-ProRule annotationAdd BLAST60
Zinc fingeri215 – 269RING-type; atypicalAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ9P793.
OrthoDBiEOG092C0ASI.
PhylomeDBiQ9P793.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEDDSLCK IVVRREPLDV LLPYYDASET TVQKILHEND STLSVKFLAG
60 70 80 90 100
VEALIKKDEL DKYKNGKACL RVWLKHKSRK RYHGYMTSTD KDEEEKNDYL
110 120 130 140 150
LKSNGSKVLR DSTRTKKFKF GKEFHCALNP SFVSDETASD SATSSSSDTN
160 170 180 190 200
KKVNRKEHNE LSLSHLSFND TSDFGSSDLS SSEIESTEND NKAPYFSLLY
210 220 230 240 250
SDGFDFIKFL HVCVCVKCHG REHRSSGKNF VYCDHCSNVY HYDCSPLPSL
260 270 280 290 300
NKETRNYSQQ NGFICPLCSK NSKDVLCNTG FVSGVSSGQD LVIPPSLADR
310 320 330 340 350
ESLSILVNYC KSIRFRCFRC RRVEYFFYLD SNPLSIQRTI THFIKKLVCN
360 370 380 390 400
ECSMHPCDIE EIIAWRTLNS LYPSKATLSN NFVSTSDLSF WSREYFVRSK
410 420 430 440 450
GKSYLHCFWC SASWLAGISL AKKKNFDGLE NASYDATKPI IPVSYTIIDK
460 470 480 490 500
VWDVQYRSGK NARTAKYKTK KHQLKAISEV TFAFVSWRGL TYYMSNWEPP
510 520 530 540 550
PKETDRNRWK AWLKGYSDLL ECLWIEKAPT ASINIDLPFT NLEWHSQPSF
560 570 580 590 600
IKGGTLMPYQ LKGLNWLYLR WYTHHPCILA DEMGLGKTVQ VISFISVLFY
610 620 630 640 650
RHKCFPVLVI VPHATVANWE RELKKWAPFL QINVLVGSEK NRSLVRDYRL
660 670 680 690 700
INQKDPKHVS THVLVISASN VEREISLLRK FQWKVLIVDE GQRLKNDQSS
710 720 730 740 750
LFYYLSSVKS DFKLLLTGTP LQNNVRELFN LLQFLNPMKI NAAELEKRYS
760 770 780 790 800
IIDTEKVTEL HQILKPFFLR RVKSEVLDNF PTKVEVIIPL SMTPVQKGLY
810 820 830 840 850
KSILSKNLSL LRNITGYANT SSSGGQRTTS LNNILMQLRK TLAHPYIYSP
860 870 880 890 900
DIEDRNLPYE LAMRSLEEAS CKFLILRLLV PKLITRGHRI LLFSQFIQQL
910 920 930 940 950
DILEDWFEYK NIAYARFDGA SSEMERQSAI DSFNAPNSEL SCFLLSTRAG
960 970 980 990 1000
GVGINLASAD TVIILDPDFN PHQDMQAIAR AHRYGQKKKV LVFVLTTRDS
1010 1020 1030 1040 1050
VEEKIIQNAQ KKLVLDHLIV ESLDQNHNSE KDLESILRHG ARALFEEAGD
1060 1070 1080 1090 1100
EPSIKYNEYS VELLISEAEK QEDTSTDESD IKSNKFGFFR VWDNKHISSN
1110 1120 1130 1140 1150
HYEVKENVLV DEEDVWSVIL KQREKDAMLE KTDETTSNRR LRAHHKIHYG
1160 1170 1180 1190 1200
EDLNIYDNSD DTDYTVNDRS SPGSPFPIET ETISSITDTL SDKQKLKYDS
1210 1220 1230 1240 1250
SVNIENLNDE SDSQKSADVH FDSILAKSLL ATTPKEDEFN KTLSTINLEV
1260 1270 1280 1290 1300
ANKLTSSEYI NDSEMQLIDD PVFYPPYEII EKNHQLVGRS LSKAVLDNFF
1310 1320 1330 1340 1350
LLSSLSDNVR CRCCGIKHLP AHCPLSIVPL EICFLCGTPH FSGRDTCPML
1360 1370 1380 1390 1400
RNKEAIYRLK DSLSKSREPF HIKKQAMARL NSFLQKKEEP TVSSSAKTNE
1410
LSSKVIIKES IINEAKTL
Length:1,418
Mass (Da):162,633
Last modified:October 1, 2000 - v1
Checksum:iDFEFD1A14D9D4BDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB87372.1.
RefSeqiNP_595385.1. NM_001021292.2.

Genome annotation databases

EnsemblFungiiSPBP35G2.10.1; SPBP35G2.10.1:pep; SPBP35G2.10.
GeneIDi2541336.
KEGGispo:SPBP35G2.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB87372.1.
RefSeqiNP_595385.1. NM_001021292.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IKFX-ray2.80A1156-1417[»]
ProteinModelPortaliQ9P793.
SMRiQ9P793.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277847. 24 interactors.
MINTiMINT-4704956.

Proteomic databases

PRIDEiQ9P793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP35G2.10.1; SPBP35G2.10.1:pep; SPBP35G2.10.
GeneIDi2541336.
KEGGispo:SPBP35G2.10.

Organism-specific databases

EuPathDBiFungiDB:SPBP35G2.10.
PomBaseiSPBP35G2.10. mit1.

Phylogenomic databases

InParanoidiQ9P793.
OrthoDBiEOG092C0ASI.
PhylomeDBiQ9P793.

Miscellaneous databases

PROiQ9P793.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIT1_SCHPO
AccessioniPrimary (citable) accession number: Q9P793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.