Reviewed,
UniProtKB/Swiss-Prot Q9P786 (MTD1_SCHPO)
Last modified
January 19, 2010.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Methylenetetrahydrofolate dehydrogenase [NAD+] EC=1.5.1.15 | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 320 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis By similarity. |
| Catalytic activity | 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH. |
| Cofactor | NAD By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism Purine biosynthesis |
| Cellular component | Cytoplasm Nucleus |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW purine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Ref.2 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.2Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro methylenetetrahydrofolate dehydrogenase (NAD+) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329671 Genomic DNA. Translation: CAB88234.1. |
| RefSeq | NP_595877.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EDZ based on UniProtKB Q02046. |
| SMR | Q9P786. Positions 14-312. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9P786. |
Genome annotation databases | |
| GeneID | 2539884. |
| GenomeReviews | Gene locus mtd1 in contig CU329671_GR. |
| KEGG | spo:SPBC1711.04. |
| NMPDR | fig|4896.1.peg.1743. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC1711.04. |
Phylogenomic databases | |
| eggNOG | fuNOG04050. |
| HOGENOM | HBG328751. |
| OMA | GNRLYGK. |
| OrthoDB | EOG9DRBVX. |
| PhylomeDB | Q9P786. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.15. 653. |
Gene expression databases | |
| ArrayExpress | Q9P786. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR000672. THF_DH/CycHdrlase. IPR020630. THF_DH/CycHdrlase_cat_dom. IPR020631. THF_DH/CycHdrlase_NAD-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view] |
| PRINTS | PR00085. THFDHDRGNASE. |
| ProtoNet | Search... |
Entry information
| Entry name | MTD1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q9P786 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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