Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methylenetetrahydrofolate dehydrogenase [NAD(+)]

Gene

mtd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.By similarity

Catalytic activityi

5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.

Cofactori

NAD+By similarity

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 188NADBy similarity2
Nucleotide bindingi210 – 211NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism, Purine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate dehydrogenase [NAD(+)] (EC:1.5.1.15)
Gene namesi
Name:mtd1
ORF Names:SPBC1711.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1711.04.
PomBaseiSPBC1711.04. mtd1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160231 – 320Methylenetetrahydrofolate dehydrogenase [NAD(+)]Add BLAST320

Proteomic databases

MaxQBiQ9P786.
PRIDEiQ9P786.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi276430. 4 interactors.
MINTiMINT-4704913.

Structurei

3D structure databases

ProteinModelPortaliQ9P786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000158212.
InParanoidiQ9P786.
KOiK00295.
OMAiVYYPIFP.
OrthoDBiEOG092C3E8S.
PhylomeDBiQ9P786.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTNKSEPN HSCKVVYASR VAETFVEQLK QHVNLFEFAP KLVGFLSNSD
60 70 80 90 100
PAARMYADWT NKTCTEIGFQ YELREVPKDD LEDAIVEANN DPSVNGIMIY
110 120 130 140 150
FPVFNDGQDQ YLQQVVSPDK DVEGLCHKYV MNMYHNIRHL DPEKTKKSIL
160 170 180 190 200
PCTPLAIVKI LEYLGVYNKI INYGNRLYGK TITIVNRSEI VGRPLAALLA
210 220 230 240 250
NDGAKVYSVD IHNVQCFTRG AGIRSKKHDV ADTNFKLEDV APISDVIICG
260 270 280 290 300
VPSANYKFPS NLVRDGAVCI CFSSEKNFDA ASLKEHAGIY VPSIGKVTIA
310 320
MLLRNLIRLT SYQLNKPVDI
Length:320
Mass (Da):35,814
Last modified:October 1, 2000 - v1
Checksum:i34BBB0B287D8B928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB88234.1.
RefSeqiNP_595877.1. NM_001021783.2.

Genome annotation databases

EnsemblFungiiSPBC1711.04.1; SPBC1711.04.1:pep; SPBC1711.04.
GeneIDi2539884.
KEGGispo:SPBC1711.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB88234.1.
RefSeqiNP_595877.1. NM_001021783.2.

3D structure databases

ProteinModelPortaliQ9P786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276430. 4 interactors.
MINTiMINT-4704913.

Proteomic databases

MaxQBiQ9P786.
PRIDEiQ9P786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1711.04.1; SPBC1711.04.1:pep; SPBC1711.04.
GeneIDi2539884.
KEGGispo:SPBC1711.04.

Organism-specific databases

EuPathDBiFungiDB:SPBC1711.04.
PomBaseiSPBC1711.04. mtd1.

Phylogenomic databases

HOGENOMiHOG000158212.
InParanoidiQ9P786.
KOiK00295.
OMAiVYYPIFP.
OrthoDBiEOG092C3E8S.
PhylomeDBiQ9P786.

Enzyme and pathway databases

UniPathwayiUPA00193.

Miscellaneous databases

PROiQ9P786.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTD1_SCHPO
AccessioniPrimary (citable) accession number: Q9P786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.