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Protein

Methylenetetrahydrofolate dehydrogenase [NAD(+)]

Gene

mtd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.By similarity

Catalytic activityi

5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.

Cofactori

NAD+By similarity

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 188NADBy similarity2
Nucleotide bindingi210 – 211NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism, Purine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate dehydrogenase [NAD(+)] (EC:1.5.1.15)
Gene namesi
Name:mtd1
ORF Names:SPBC1711.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPBC1711.04
PomBaseiSPBC1711.04 mtd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160231 – 320Methylenetetrahydrofolate dehydrogenase [NAD(+)]Add BLAST320

Proteomic databases

MaxQBiQ9P786
PaxDbiQ9P786
PRIDEiQ9P786

PTM databases

iPTMnetiQ9P786

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi276430, 4 interactors
STRINGi4896.SPBC1711.04.1

Structurei

3D structure databases

ProteinModelPortaliQ9P786
SMRiQ9P786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000158212
InParanoidiQ9P786
KOiK00295
OMAiPCTPLAM
OrthoDBiEOG092C3E8S
PhylomeDBiQ9P786

Family and domain databases

CDDicd01079 NAD_bind_m-THF_DH, 1 hit
InterProiView protein in InterPro
IPR035812 m-THF_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR000672 THF_DH/CycHdrlase
IPR020630 THF_DH/CycHdrlase_cat_dom
IPR020631 THF_DH/CycHdrlase_NAD-bd_dom
PANTHERiPTHR10025 PTHR10025, 1 hit
PfamiView protein in Pfam
PF00763 THF_DHG_CYH, 1 hit
PF02882 THF_DHG_CYH_C, 1 hit
PRINTSiPR00085 THFDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTNKSEPN HSCKVVYASR VAETFVEQLK QHVNLFEFAP KLVGFLSNSD
60 70 80 90 100
PAARMYADWT NKTCTEIGFQ YELREVPKDD LEDAIVEANN DPSVNGIMIY
110 120 130 140 150
FPVFNDGQDQ YLQQVVSPDK DVEGLCHKYV MNMYHNIRHL DPEKTKKSIL
160 170 180 190 200
PCTPLAIVKI LEYLGVYNKI INYGNRLYGK TITIVNRSEI VGRPLAALLA
210 220 230 240 250
NDGAKVYSVD IHNVQCFTRG AGIRSKKHDV ADTNFKLEDV APISDVIICG
260 270 280 290 300
VPSANYKFPS NLVRDGAVCI CFSSEKNFDA ASLKEHAGIY VPSIGKVTIA
310 320
MLLRNLIRLT SYQLNKPVDI
Length:320
Mass (Da):35,814
Last modified:October 1, 2000 - v1
Checksum:i34BBB0B287D8B928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB88234.1
RefSeqiNP_595877.1, NM_001021783.2

Genome annotation databases

EnsemblFungiiSPBC1711.04.1; SPBC1711.04.1:pep; SPBC1711.04
GeneIDi2539884
KEGGispo:SPBC1711.04

Similar proteinsi

Entry informationi

Entry nameiMTD1_SCHPO
AccessioniPrimary (citable) accession number: Q9P786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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