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Protein

GMP synthase [glutamine-hydrolyzing]

Gene

gua1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] (gua1)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96For GATase activityBy similarity1
Active sitei189For GATase activityBy similarity1
Active sitei191For GATase activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi244 – 250ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processGMP biosynthesis, Purine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-73817 Purine ribonucleoside monophosphate biosynthesis
UniPathwayiUPA00189; UER00296

Protein family/group databases

MEROPSiC26.957

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:gua1
ORF Names:SPAP7G5.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAP7G5.02c
PomBaseiSPAP7G5.02c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861541 – 539GMP synthase [glutamine-hydrolyzing]Add BLAST539

Proteomic databases

MaxQBiQ9P772
PaxDbiQ9P772
PRIDEiQ9P772

PTM databases

iPTMnetiQ9P772

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4896.SPAP7G5.02c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P772
SMRiQ9P772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 215Glutamine amidotransferase type-1Add BLAST196
Domaini216 – 413GMPS ATP-PPaseAdd BLAST198

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000223964
InParanoidiQ9P772
KOiK01951
OMAiKRKIIGH
OrthoDBiEOG092C1KAD
PhylomeDBiQ9P772

Family and domain databases

CDDicd01742 GATase1_GMP_Synthase, 1 hit
cd01997 GMP_synthase_C, 1 hit
Gene3Di3.40.50.620, 1 hit
3.40.50.880, 1 hit
HAMAPiMF_00344 GMP_synthase, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR001674 GMP_synth_C
IPR004739 GMP_synth_GATase
IPR022955 GMP_synthase
IPR025777 GMPS_ATP_PPase_dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PF00958 GMP_synt_C, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR00884 guaA_Cterm, 1 hit
TIGR00888 guaA_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit
PS51553 GMPS_ATP_PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTEVPGEV STSVSSYFDT ILILDFGSQY SHLIARRLRE IHVYAELLPC
60 70 80 90 100
TQKIEALPFK PIGVILSGGP YSVYDDIAPH VDPAVFELGV PVLGICYGMQ
110 120 130 140 150
EIAWLNGRCV EPGIEREYGP ATVSMEPEIK TEVFKSFFNS MPKEFEVWMS
160 170 180 190 200
HGDRLSALPN GYETIGRTKN SPFAVIAHVT KPIIGLQFHP EVTHTPLGLQ
210 220 230 240 250
LIKNFAIEIC HAKPNWSMEN FVDKEILRIR KMIGPSDHVI GAVSGGVDST
260 270 280 290 300
VASKVLKEAI GDRFHAIMVD NGLLRLNEAE IVRETLNKHL GIQLTVVDAS
310 320 330 340 350
EEFIGKLKGV TDPEKKRKII GNTFIHVFER EAERIVKETN GKVEYLLQGT
360 370 380 390 400
LYPDVIESIS FKGPSQTIKT HHNVGGLLKD MKLKLIEPLR ELFKDEVRAL
410 420 430 440 450
GELLGIEHSL VWRHPFPGPG LGIRILGEVN AAQLEIARKA DHIFITEIRN
460 470 480 490 500
HGYYDKISQA FAALLPVKAV GVMGDKRTHE QVIALRAITT SDFMTADWYD
510 520 530
GFSIKFLKLV SSRICNEVSG VNRVLYDISS KPPATVEME
Length:539
Mass (Da):60,044
Last modified:October 1, 2000 - v1
Checksum:iF83A1C4575F71723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB88269.1
RefSeqiNP_594312.1, NM_001019735.2

Genome annotation databases

EnsemblFungiiSPAP7G5.02c.1; SPAP7G5.02c.1:pep; SPAP7G5.02c
GeneIDi2542573
KEGGispo:SPAP7G5.02c

Similar proteinsi

Entry informationi

Entry nameiGUAA_SCHPO
AccessioniPrimary (citable) accession number: Q9P772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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