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Protein

Probable succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

Gene

8D4.130

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861Tele-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial (EC:6.2.1.5)
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name:
SCS-alpha
Gene namesi
ORF Names:8D4.130, NCU01227
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU01227.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 333Probable succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrialPRO_0000260162
Transit peptidei1 – ?MitochondrionSequence analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9P727.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9P727.
SMRiQ9P727. Positions 30-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000239685.
InParanoidiQ9P727.
KOiK01899.
OMAiIMEMVAY.
OrthoDBiEOG092C3IM6.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIARQTRP AGKLVQQLSK RAYSSNSSPY AATINNLKIN GDTKVLFQGF
60 70 80 90 100
TGKQGTFHAQ QAIEYGTNVV GGTNPKKAGQ THLDRPVFSN VSEAVKETGA
110 120 130 140 150
TATAIFVPPP LAAAGIEEAL QAEIPLAVCI TEGIPQHDMV RITSMLKTQS
160 170 180 190 200
KTRLVGPNCP GIIAPGQCKI GIMPGFIHKR GRIGIVSRSG TLTYEAVNQT
210 220 230 240 250
TQAGLGQSLV VGIGGDPFSG TNFIDCLKVF LEDGDTDGII MIGEIGGSAE
260 270 280 290 300
EEAADFLKEY NTKNGGKPVV SFIAGISAPP GRRMGHAGAI VAGGKGGADS
310 320 330
KIKALEAAGV VVERSPASLG KALRDEFVRR DLL
Length:333
Mass (Da):34,738
Last modified:October 1, 2000 - v1
Checksum:iBA6FBF63AD918BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353819 Genomic DNA. Translation: CAB88555.1.
CM002240 Genomic DNA. Translation: EAA32357.1.
PIRiT48739.
RefSeqiXP_961593.1. XM_956500.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000004336; EFNCRP00000004336; EFNCRG00000004330.
GeneIDi3877725.
KEGGincr:NCU01227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353819 Genomic DNA. Translation: CAB88555.1.
CM002240 Genomic DNA. Translation: EAA32357.1.
PIRiT48739.
RefSeqiXP_961593.1. XM_956500.3.

3D structure databases

ProteinModelPortaliQ9P727.
SMRiQ9P727. Positions 30-333.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9P727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000004336; EFNCRP00000004336; EFNCRG00000004330.
GeneIDi3877725.
KEGGincr:NCU01227.

Organism-specific databases

EuPathDBiFungiDB:NCU01227.

Phylogenomic databases

HOGENOMiHOG000239685.
InParanoidiQ9P727.
KOiK01899.
OMAiIMEMVAY.
OrthoDBiEOG092C3IM6.

Enzyme and pathway databases

UniPathwayiUPA00223.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUCA_NEUCR
AccessioniPrimary (citable) accession number: Q9P727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.