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Q9P6R5 (GPI14_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GPI mannosyltransferase 1
EC=2.4.1.-
Alternative name(s):
GPI mannosyltransferase I
Short name=GPI-MT-I
Glycosylphosphatidylinositol-anchor biosynthesis protein 14
Gene names
Name:gpi14
ORF Names:SPBC13E7.05
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity By similarity.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PIGM family.

Sequence caution

The sequence CAB89880.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371GPI mannosyltransferase 1
PRO_0000246233

Regions

Transmembrane64 – 8421Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane344 – 36421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9P6R5 [UniParc].

Last modified July 25, 2006. Version 2.
Checksum: 96B68CC3452E0245

FASTA37143,105
        10         20         30         40         50         60 
MRLVLLNYGI WHDRRSALKF TDIDYFVFSD ASKYVSIGMS PYMRDTYRYT PMLAILLLPT 

        70         80         90        100        110        120 
QYGFPSWGKY LFSISDLIAG WLMIKLLSRR ISYKRSLIYS SFWILNPFVA IISTRGNCEA 

       130        140        150        160        170        180 
ILGILSIALL YLIEKKSVWL ASLILGFSVH FKIYPFMYGI AFLVYFSKPK KGSTFMEKFL 

       190        200        210        220        230        240 
SLLSINQLKI VVGSLFMFTI CNLLMYYLYG SPFLEHTYLY HFGRTDHRHN FSLHHLNLYY 

       250        260        270        280        290        300 
ESSFGAKASS LFAFLPQLSL CMLIPLVFGK KNLPGTLFAQ TFAFVTFNKV CTSQYFMWYL 

       310        320        330        340        350        360 
VFLPLVLPNS KLLSKKGLIC LSLWIIGQLL WLISAYNLEM LGKSVFIPLW LSGLLFFFFN 

       370 
VYELKIILDS L

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB89880.1. Different initiation.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9P6R5.

Protein family/group databases

CAZyGT50. Glycosyltransferase Family 50.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus gpi14 in contig CU329671_GR.

Organism-specific databases

GeneDB_SpombeSPBC13E7.05.

Phylogenomic databases

eggNOGfuNOG07722.
GeneTreeEFGT00050000005876.
OrthoDBEOG4643N0.

Gene expression databases

ArrayExpressQ9P6R5.

Family and domain databases

InterProIPR007704. Mannosyltransferase_DXD.
[Graphical view]
PANTHERPTHR12886. Mannos_trans_DXD. 1 hit.
PfamPF05007. Mannosyl_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPI14_SCHPO
AccessionPrimary (citable) accession number: Q9P6R5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: December 14, 2011
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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