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Q9P6P9 (PDK_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
Short name=Pyruvate dehydrogenase kinase
EC=2.7.11.2
Gene names
ORF Names:SPAC644.11c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism By similarity. UniProtKB P40530

Catalytic activity

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate. UniProtKB P40530

Subcellular location

Mitochondrion matrix Ref.2.

Sequence similarities

Belongs to the PDK/BCKDK protein kinase family.

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential UniProtKB P40530
Chain? – 425[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial UniProtKB P40530PRO_0000259609

Regions

Domain180 – 418239Histidine kinase
Nucleotide binding296 – 3038ATP By similarity
Nucleotide binding355 – 3562ATP By similarity
Nucleotide binding379 – 3846ATP By similarity

Sites

Binding site3361ATP By similarity

Amino acid modifications

Modified residue1781Phosphohistidine; by autocatalysis By similarity UniProtKB Q16654

Sequences

Sequence LengthMass (Da)Tools
Q9P6P9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 131D3B7ACA8995B7

FASTA42548,187
        10         20         30         40         50         60 
MSVLGKTLQE KVNLLAQYPQ TGLSLKQLVY FGKNPTPGTL FRAGLFLRDE LPIRLARRIQ 

        70         80         90        100        110        120 
DLQNLSPMLR SMKRISSVKA AYGRSMEEII ELKGVELPKC LPKHARYHNA PKWRSSLMDS 

       130        140        150        160        170        180 
EILHNPSLAN THLDSSKGRY FETDFSDQDN GVDCNWPESL LKFNSNFAYL LNTIRTRHDN 

       190        200        210        220        230        240 
VAVEIALDIQ EYRRKTNQID NSIQIFLDRF YMSRIGIRML LGQYIALVSE PPRENYVGVI 

       250        260        270        280        290        300 
STRANIYQII EGAAENAKYI CRLAYGLFEA PEIQIICDPS LEMMYVESHL NHAVFEILKN 

       310        320        330        340        350        360 
SLRATVEFHG VDSDFFPPIK VIVAKGQEDI TIKISDEGGG ISRRNIPLVW SYMFTTASPT 

       370        380        390        400        410        420 
LTDDPHDIVS ANSTTPMAGF GFGLPLARLY TRYFGGDLEL ISMEGYGTDV YIHLNRLCES 


AEPLQ

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAB90138.1.
RefSeqNP_593879.1. NM_001019309.2.

3D structure databases

HSSPHSSP built from PDB template 1Y8P based on UniProtKB Q15120.
ProteinModelPortalQ9P6P9.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC644.11c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC644.11c.1; SPAC644.11c.1:pep; SPAC644.11c.
GeneID2543651.
KEGGspo:SPAC644.11c.

Organism-specific databases

PomBaseSPAC644.11c.

Phylogenomic databases

eggNOGCOG0642.
HOGENOMHOG000164315.
KOK00898.
OMADICHEAI.
OrthoDBEOG49S9G2.

Family and domain databases

Gene3D1.20.140.20. 2 hits.
3.30.565.10. 1 hit.
InterProIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF69012. BCDHK/PDK_N. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804657.

Entry information

Entry namePDK_SCHPO
AccessionPrimary (citable) accession number: Q9P6P9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents