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Protein

Serine/threonine-protein kinase ppk15

Gene

ppk15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591ATPPROSITE-ProRule annotation
Active sitei257 – 2571Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi136 – 1449ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ppk15 (EC:2.7.11.1)
Gene namesi
Name:ppk15
ORF Names:SPAC1E11.03, SPAC823.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.03.
PomBaseiSPAC823.03. ppk15.

Subcellular locationi

GO - Cellular componenti

  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • mitotic spindle pole body Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Serine/threonine-protein kinase ppk15PRO_0000086140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Phosphoserine1 Publication
Modified residuei56 – 561Phosphoserine1 Publication
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei291 – 2911Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P6P3.

PTM databases

iPTMnetiQ9P6P3.

Interactioni

Protein-protein interaction databases

BioGridi278701. 24 interactions.
MINTiMINT-4704488.

Structurei

3D structure databases

ProteinModelPortaliQ9P6P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 458329Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000220863.
InParanoidiQ9P6P3.
KOiK18670.
OMAiKCQNMQT.
OrthoDBiEOG7WDNBB.
PhylomeDBiQ9P6P3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P6P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDSPILPL SNNPPAARTH DHSQRNNHAR HVSSSGTTLF APVKPATKKY
60 70 80 90 100
NYRRVSPHGS YISPLEAMTV KLADTYSICN PKFQFSSEQN PRRPLTKPSE
110 120 130 140 150
GVHNHGFDNV NHDYVLYVND LLGTDEGRKY LILDTLGHGT FGQVARCQDL
160 170 180 190 200
KTQQIVAIKV IKNKPAFYNQ CVMEVSILEL LNNKYDPEDK RHLIRLYDQF
210 220 230 240 250
MHKNHLCLVF ELLSINLYEL IKQNQFRGLH LSLVRSFATQ LLSCTSLLKQ
260 270 280 290 300
ARIIHCDLKP ENILLQDLSS PIVKVIDFGS ACHERQTVYT YIQSRFYRSP
310 320 330 340 350
EVILGLHYNC GIDMWSLGCI LAELFLGLPL FPGNSEYNQL CRIVDMLGNP
360 370 380 390 400
PTWMLEMGKN SKKYYNSGFV NGRKTYELKS IEQFSIENNK TEQPGKQYFG
410 420 430 440 450
EKTLDAIVLN YPRRKTTPKL TPEEHEERLC FIDFIKQFLE LNPLKRWTPD
460 470 480 490 500
QAKNHPFITG ASFSQYCIDK QKPLLTTQRT RNRSHTIGNQ AVVPPSLQRA
510 520 530
STYVSNEPEE FVHTRPLPQY YPPANENENV DEFF
Length:534
Mass (Da):61,491
Last modified:October 1, 2000 - v1
Checksum:iCAB4EE92FF986DD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90148.1.
Z98599 Genomic DNA. Translation: CAB40210.1.
PIRiT38058.
RefSeqiNP_593830.1. NM_001019259.2.

Genome annotation databases

EnsemblFungiiSPAC823.03.1; SPAC823.03.1:pep; SPAC823.03.
GeneIDi2542228.
KEGGispo:SPAC823.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90148.1.
Z98599 Genomic DNA. Translation: CAB40210.1.
PIRiT38058.
RefSeqiNP_593830.1. NM_001019259.2.

3D structure databases

ProteinModelPortaliQ9P6P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278701. 24 interactions.
MINTiMINT-4704488.

PTM databases

iPTMnetiQ9P6P3.

Proteomic databases

MaxQBiQ9P6P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC823.03.1; SPAC823.03.1:pep; SPAC823.03.
GeneIDi2542228.
KEGGispo:SPAC823.03.

Organism-specific databases

EuPathDBiFungiDB:SPAC823.03.
PomBaseiSPAC823.03. ppk15.

Phylogenomic databases

HOGENOMiHOG000220863.
InParanoidiQ9P6P3.
KOiK18670.
OMAiKCQNMQT.
OrthoDBiEOG7WDNBB.
PhylomeDBiQ9P6P3.

Miscellaneous databases

PROiQ9P6P3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: IDENTIFICATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33; SER-56; SER-60 AND TYR-291, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPPK15_SCHPO
AccessioniPrimary (citable) accession number: Q9P6P3
Secondary accession number(s): Q9Y7I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.