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Protein

ATP-dependent rRNA helicase rrp3

Gene

rrp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi90 – 978ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent rRNA helicase rrp3Curated (EC:3.6.4.13By similarity)
Gene namesi
Name:rrp3By similarity
ORF Names:SPAC823.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.08c.
PomBaseiSPAC823.08c. rrp3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465ATP-dependent rRNA helicase rrp3PRO_0000232278Add
BLAST

Proteomic databases

MaxQBiQ9P6N8.

Interactioni

Subunit structurei

Interacts with the SSU processome.By similarity

Protein-protein interaction databases

BioGridi279986. 1 interaction.
MINTiMINT-4704435.

Structurei

3D structure databases

ProteinModelPortaliQ9P6N8.
SMRiQ9P6N8. Positions 43-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 248172Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini275 – 419145Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 7429Q motifCuratedAdd
BLAST
Motifi196 – 1994DEAD boxCurated

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.Curated

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000268802.
InParanoidiQ9P6N8.
KOiK14777.
OMAiFEATQAK.
OrthoDBiEOG092C1VLP.
PhylomeDBiQ9P6N8.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P6N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSEKKLTE DKKNSSLNKK IETSNSSSEK SSENNNGDSQ NNEAPKTFKE
60 70 80 90 100
LGVIDELCEA CEKLGFKTPT PIQQEAIPVV LNKRDVIGLA QTGSGKTAAF
110 120 130 140 150
ALPVIQELWN NPSPFFAVVL APTRELAYQI SEQFEAIGGS IGVRSVVIVG
160 170 180 190 200
GMDMVTQAVA LSKKPHVLVC TPGRLMDHLE NTKGFSLKNL KYLIMDEADR
210 220 230 240 250
LLDMDFGPII DKILKIIPHE RRTLLFSATM TSKVEKLQRA SLHQPVRVAV
260 270 280 290 300
SSKFSTVDTL IQRYLFFPFK HKDTYLVYLV NELAGNSIII FARTVNDTQR
310 320 330 340 350
LAILLRTLGF SAIPLHGQLS QSNRLGALNK FKSGARSTLV ATDVAARGLD
360 370 380 390 400
IPLVDVVINY DIPTDSKAYI HRVGRTARAG RAGKSIALVT QYDLEPFLRI
410 420 430 440 450
EATIGKKMQE YEIDKEGVFL LSERVGEAQR EAIIQMKEIH DRRKSKGKLH
460
TKRKRDDLDR EEQIY
Length:465
Mass (Da):51,864
Last modified:October 1, 2000 - v1
Checksum:i7C0823014329DDE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90153.1.
RefSeqiNP_593835.1. NM_001019264.2.

Genome annotation databases

EnsemblFungiiSPAC823.08c.1; SPAC823.08c.1:pep; SPAC823.08c.
GeneIDi2543571.
KEGGispo:SPAC823.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90153.1.
RefSeqiNP_593835.1. NM_001019264.2.

3D structure databases

ProteinModelPortaliQ9P6N8.
SMRiQ9P6N8. Positions 43-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279986. 1 interaction.
MINTiMINT-4704435.

Proteomic databases

MaxQBiQ9P6N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC823.08c.1; SPAC823.08c.1:pep; SPAC823.08c.
GeneIDi2543571.
KEGGispo:SPAC823.08c.

Organism-specific databases

EuPathDBiFungiDB:SPAC823.08c.
PomBaseiSPAC823.08c. rrp3.

Phylogenomic databases

HOGENOMiHOG000268802.
InParanoidiQ9P6N8.
KOiK14777.
OMAiFEATQAK.
OrthoDBiEOG092C1VLP.
PhylomeDBiQ9P6N8.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ9P6N8.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRP3_SCHPO
AccessioniPrimary (citable) accession number: Q9P6N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.