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Protein

Mitochondrial glycine transporter

Gene

SPAC823.10c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:SPAC823.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.10c
PomBaseiSPAC823.10c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 43Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei70 – 96Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei110 – 135Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei163 – 186Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei212 – 238Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei267 – 285Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108011 – 296Mitochondrial glycine transporterAdd BLAST296

Proteomic databases

PaxDbiQ9P6N6
PRIDEiQ9P6N6

PTM databases

iPTMnetiQ9P6N6

Interactioni

Protein-protein interaction databases

BioGridi279783, 6 interactors
STRINGi4896.SPAC823.10c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P6N6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 95Solcar 1UniRule annotationAdd BLAST84
Repeati104 – 188Solcar 2UniRule annotationAdd BLAST85
Repeati208 – 292Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
InParanoidiQ9P6N6
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU
PhylomeDBiQ9P6N6

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9P6N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEIKKTEKL GVKSSKHLAA GALGGFISST TLQPLDLLKT RCQQSQRDSL
60 70 80 90 100
PKMVRRIILH EGGVFSLWKG TLPSILRSTT GSSCYFYFLN WLRHFAPQSK
110 120 130 140 150
NIASSHIQNL WMGGFARAAV GFAFMPVTVI KVRYESNLYS YTTIYSSIRD
160 170 180 190 200
IWKKEGISGF FRGFGVTALR DAPHAGLYVY FYELSKQNLH KLFDRFSPSS
210 220 230 240 250
SVQGTVPHRN IVNVMSGLIS GATATAITNP FDMLKTRVQL EPHIYKNFLH
260 270 280 290
SAKLVYANEG FRGFLDGFFL RVLRKSISST ITWSVYEWAL HRKVIK
Length:296
Mass (Da):33,480
Last modified:October 1, 2000 - v1
Checksum:iD921BC6097D55F2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB90155.1
RefSeqiNP_593837.1, NM_001019266.2

Genome annotation databases

EnsemblFungiiSPAC823.10c.1; SPAC823.10c.1:pep; SPAC823.10c
GeneIDi2543361
KEGGispo:SPAC823.10c

Similar proteinsi

Entry informationi

Entry nameiS2538_SCHPO
AccessioniPrimary (citable) accession number: Q9P6N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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