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Protein

Solute carrier family 25 member 38 homolog

Gene

SPAC823.10c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial carrier required for the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:SPAC823.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.10c.
PomBaseiSPAC823.10c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 43Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei70 – 96Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei110 – 135Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei163 – 186Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei212 – 238Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei267 – 285Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108011 – 296Solute carrier family 25 member 38 homologAdd BLAST296

Proteomic databases

PRIDEiQ9P6N6.

PTM databases

iPTMnetiQ9P6N6.

Interactioni

Protein-protein interaction databases

BioGridi279783. 4 interactors.
STRINGi4896.SPAC823.10c.1.

Structurei

3D structure databases

ProteinModelPortaliQ9P6N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 95Solcar 1Add BLAST84
Repeati104 – 188Solcar 2Add BLAST85
Repeati208 – 292Solcar 3Add BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978.
InParanoidiQ9P6N6.
KOiK15118.
OMAiTVYEQMM.
OrthoDBiEOG092C3NVU.
PhylomeDBiQ9P6N6.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
IPR030847. SLC25A38.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9P6N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEIKKTEKL GVKSSKHLAA GALGGFISST TLQPLDLLKT RCQQSQRDSL
60 70 80 90 100
PKMVRRIILH EGGVFSLWKG TLPSILRSTT GSSCYFYFLN WLRHFAPQSK
110 120 130 140 150
NIASSHIQNL WMGGFARAAV GFAFMPVTVI KVRYESNLYS YTTIYSSIRD
160 170 180 190 200
IWKKEGISGF FRGFGVTALR DAPHAGLYVY FYELSKQNLH KLFDRFSPSS
210 220 230 240 250
SVQGTVPHRN IVNVMSGLIS GATATAITNP FDMLKTRVQL EPHIYKNFLH
260 270 280 290
SAKLVYANEG FRGFLDGFFL RVLRKSISST ITWSVYEWAL HRKVIK
Length:296
Mass (Da):33,480
Last modified:October 1, 2000 - v1
Checksum:iD921BC6097D55F2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90155.1.
RefSeqiNP_593837.1. NM_001019266.2.

Genome annotation databases

EnsemblFungiiSPAC823.10c.1; SPAC823.10c.1:pep; SPAC823.10c.
GeneIDi2543361.
KEGGispo:SPAC823.10c.

Similar proteinsi

Entry informationi

Entry nameiS2538_SCHPO
AccessioniPrimary (citable) accession number: Q9P6N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families