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Protein

Dihydrosphingosine 1-phosphate phosphatase C823.11

Gene

SPAC823.11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiR-SPO-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrosphingosine 1-phosphate phosphatase C823.11 (EC:3.1.3.-)
Gene namesi
ORF Names:SPAC823.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.11.
PomBaseiSPAC823.11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474LumenalBy similarityAdd
BLAST
Transmembranei75 – 9521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini96 – 994CytoplasmicBy similarity
Transmembranei100 – 12021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini121 – 17050LumenalBy similarityAdd
BLAST
Transmembranei171 – 19121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini192 – 1954CytoplasmicBy similarity
Transmembranei196 – 21621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini217 – 23317LumenalBy similarityAdd
BLAST
Transmembranei234 – 25421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini255 – 2595CytoplasmicBy similarity
Transmembranei260 – 28021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 29313LumenalBy similarityAdd
BLAST
Transmembranei294 – 31421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini315 – 38773CytoplasmicBy similarityAdd
BLAST
Transmembranei388 – 40821Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini409 – 4113LumenalBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Dihydrosphingosine 1-phosphate phosphatase C823.11PRO_0000359401Add
BLAST

Proteomic databases

MaxQBiQ9P6N5.

Structurei

3D structure databases

ProteinModelPortaliQ9P6N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi229 – 2346Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9P6N5.
OMAiGNHPAEH.
OrthoDBiEOG7F519P.
PhylomeDBiQ9P6N5.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHKKKNVDI PSSQKYLGIQ HVNFYSNAFG KESLRFQLRE LILPIVRKET
60 70 80 90 100
RLLYKIQSFF RNPWLDVYFM YTATLGTHVF FMLALPIFFW SGCIYYTLDI
110 120 130 140 150
TQLFAAGVYF SGCIKDYFCL PRPRSPPMVR LTLSSDAEYE YGFPSTHTTN
160 170 180 190 200
AMATGFYSLF LLLSMSDSMS SISYYFLLSL VLLYIASISL GRIYCGMHGF
210 220 230 240 250
MDVSTGTILG VTLAIFQWKY ADFFHNVWSS SSTSVPILSV VLALFFIWFH
260 270 280 290 300
PQPAERCICL EDSISFISVI MGIDLGTWFA SPESLSHLHD NLNSYFLLKF
310 320 330 340 350
FVRVLFGVCM ILIWKSFAKQ ALLAVLPPIF KSLRLSYLEP KSQSEKGIRA
360 370 380 390 400
ATGSNHSPGN IGTELGVITS HQSHPHPVRF DIETIARIIV YSGIGFLCTY
410
FAPKVFLKWK I
Length:411
Mass (Da):46,847
Last modified:October 1, 2000 - v1
Checksum:i3EFC81F484B81862
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90156.1.
RefSeqiNP_593838.1. NM_001019267.2.

Genome annotation databases

EnsemblFungiiSPAC823.11.1; SPAC823.11.1:pep; SPAC823.11.
GeneIDi2543496.
KEGGispo:SPAC823.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90156.1.
RefSeqiNP_593838.1. NM_001019267.2.

3D structure databases

ProteinModelPortaliQ9P6N5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ9P6N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC823.11.1; SPAC823.11.1:pep; SPAC823.11.
GeneIDi2543496.
KEGGispo:SPAC823.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC823.11.
PomBaseiSPAC823.11.

Phylogenomic databases

InParanoidiQ9P6N5.
OMAiGNHPAEH.
OrthoDBiEOG7F519P.
PhylomeDBiQ9P6N5.

Enzyme and pathway databases

ReactomeiR-SPO-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROiQ9P6N5.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiDS1PP_SCHPO
AccessioniPrimary (citable) accession number: Q9P6N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.