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Protein

Kinetochore protein mis14

Gene

mis14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialized chromatin at the centromere.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic cell cycle Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein mis14
Alternative name(s):
NMS complex subunit mis14
Gene namesi
Name:mis14
ORF Names:SPAC688.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC688.02c
PomBaseiSPAC688.02c mis14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002783901 – 210Kinetochore protein mis14Add BLAST210

Proteomic databases

MaxQBiQ9P6M3
PaxDbiQ9P6M3
PRIDEiQ9P6M3

Interactioni

Subunit structurei

Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25. Interacts with mis12.3 Publications

Protein-protein interaction databases

BioGridi279902, 7 interactors
IntActiQ9P6M3, 1 interactor
STRINGi4896.SPAC688.02c.1

Family & Domainsi

Phylogenomic databases

InParanoidiQ9P6M3
KOiK11561
OMAiYEPFDTR
OrthoDBiEOG092C592G
PhylomeDBiQ9P6M3

Family and domain databases

InterProiView protein in InterPro
IPR013950 Mis14/Nsl1
PANTHERiPTHR31749 PTHR31749, 1 hit
PfamiView protein in Pfam
PF08641 Mis14, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P6M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHGDASVL PKIALESIND YSYVKSVFRQ AIQEKLAIHL PEQASREAGM
60 70 80 90 100
GREDQLRIRV KEMLNELIES TFSIIQENVT INGFDANSAL QDPKNSDQIE
110 120 130 140 150
PFDLALRTRV QQLFNEVEDA HVLVARYRKS VPAQYEKAYV DAMEQQTAFL
160 170 180 190 200
RNVKDDYVSL QDKEVENPDE QTSTTVFRKE DIDRYEQTIA KVAYLKKNLP
210
RVVARLEKTP
Length:210
Mass (Da):24,122
Last modified:October 1, 2000 - v1
Checksum:i400DC20681812390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB90769.1
RefSeqiNP_594061.1, NM_001019485.2

Genome annotation databases

EnsemblFungiiSPAC688.02c.1; SPAC688.02c.1:pep; SPAC688.02c
GeneIDi2543482
KEGGispo:SPAC688.02c

Similar proteinsi

Entry informationi

Entry nameiMIS14_SCHPO
AccessioniPrimary (citable) accession number: Q9P6M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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